Publicaties van medewerkers Sint Antonius Ziekenhuis 2007
Dissertaties
Al-Toma A-B. Complicated Coeliac Disease : Diagnosis and Management. Amsterdam: Vrije Universiteit, 2007.
Braam RL. Methodological aspects of blood pressure measurement and adherence to antihypertensive drug therapy. Enschede: Gildeprint Drukkerijen B.V., 2007.
Fioole B. Strategies in liver surgery. Utrecht: Utrecht University, 2007.
Gerritsen WBM. Biomarkers of oxidative stress. Gildeprint Drukkerijen: Enschede, 2007.
Peeters MYM. Don't be afraid! Population PK-PD modeling as the basis for individualized dosing in children and critically ill. Wageningen: Ponsen & Looijen B.V., 2007.
Planken RN. Hemodialysis vascular access imaging : Duplex ultrasound and contrast-enhanced magnetic resonance angiography. Maastricht: Datawyse, Universitaire Pers Maastricht, 2007.
van de Garde EMW. Drug effects on the risk and prognosis of community-acquired pneumonia. Gildeprint Drukkerijen: Enschede, 2007.
van der Velden AMT. Antibody responses to vaccination and immune function in patients with haematological malignancies : studies in patients with chronic lymphocytic leukaemia and autologous stem cell transplant recipients. Ouderkerk aan de Amstel: Drukkerij Aeroprint, 2007.
van Strijen M. Diagnosing pulmonary embolism : establishing and consolidating the role of spiral CT. s.l.: s.n., 2007.
van Tuyl SAC. Videocapsule Endoscopy : Fiction becoming fact. Enschede: Gildeprint drukkerijen, 2007.
Aantal referenties 2007: 431
Agterof MJ, van Bladel ER, Snijder RJ, Biesma DH. Early mortality in patients with pulmonary embolism. 19e Internistendagen : abstractboek :25, 26 & 27 april 2007 MECC Maastricht 2007;87.
Agterof MJ, Grutters JC, ter Borg EJ. The anti-synthetasesyndrome. 19e Internistendagen : abstractboek :25, 26 & 27 april 2007 MECC Maastricht 2007;35-36.
Agterof MJ, van der Bruggen T, Tersmette M, ter Borg EJ, van den Bosch JM, Biesma DH. Nocardiosis: a case series and a mini review of clinical and microbiological features. Netherlands Journal of Medicine 2007; 65(6):199-202.
Abstract: Infections caused by Nocardia species are uncommon and have a wide variety of clinical manifestations in immunocompetent and immunocompromised patients. The diagnosis of nocardiosis can easily be missed because there are no characteristic symptoms. We present one case of a Nocardia infection in detail and give a brief description of eight other cases, including a relatively unique type of Nocardia veterana, diagnosed in our hospital during a five-year period. The diversity of clinical manifestations, microbiological identification and general principles of treatment of nocardiosis are reviewed
Al-Toma A, Verbeek WH, Hadithi M, von Blomberg BM, Mulder CJ. Survival in Refractory Coeliac Disease and Enteropathy associated T cell Lymphoma: Retrospective evaluation of single centre experience. DDW Washington 2007.
Al-Toma A, Visser OJ, van Roessel HM, von Blomberg BM, Verbeek WH, Scholten PE, Ossenkoppele GJ, Huijgens PC, Mulder CJ. Autologous hematopoietic stem cell transplantation in refractory celiac disease with aberrant T cells. Blood 2007; 109(5):2243-2249.
Abstract: Autologous hematopoietic stem cell transplantation (ASCT) is an increasingly accepted treatment for refractory autoimmune diseases. Refractory celiac disease with aberrant T cells (RCD type II) is unresponsive to available therapies and carries a high risk of transition into enteropathy associated T-cell lymphoma (EATL). This study reports on the feasibility, safety, and efficacy of ASCT in patients with RCD type II. Thirteen patients with RCD type II were evaluated. Seven patients (4 men, 3 women, mean age 61.5 years [range, 51-69 years]) underwent transplantation. After conditioning with fludarabine and melphalan, ASCT was performed. Patients were monitored for response, adverse effects, and hematopoietic reconstitution. All 7 patients completed the mobilization and leukapheresis procedures successfully and subsequently underwent conditioning and transplantation. Engraftment occurred in all patients. No major nonhematologic toxicity or transplantation-related mortality was observed. There was a significant reduction in the aberrant T cells in duodenal biopsies associated with improvement in clinical well-being and normalization of hematologic and biochemical markers (mean follow-up, 15.5 months; range, 7-30 months). One patient died 8 months after transplantation from progressive neuroceliac disease. These preliminary results showed that high-dose chemotherapy followed by ASCT seems feasible and safe and might result in long-term improvement of patients with RCD type II whose condition did not respond promptly to available drugs
Al-Toma A, Verbeek WH, Visser OJ, Kuijpers KC, Oudejans JJ, Kluin-Nelemans HC, Mulder CJ, Huijgens PC. Disappointing outcome of autologous stem cell transplantation for enteropathy-associated T-cell lymphoma. Digestive & Liver Disease 2007; 39(7):634-641.
Abstract: BACKGROUND: Despite treatment, enteropathy-associated T-cell lymphoma has a very poor outcome. Chemotherapy can be complicated by small bowel perforation, gastrointestinal bleeding and development of enterocolic fistulae. Here we report on the feasibility, safety and efficacy of high-dose chemotherapy followed by autologous stem cell transplantation in patients with enteropathy-associated T-cell lymphoma (three upfront and one at relapse), with or without prior partial small bowel resection. METHODS: Four patients [two males, two females, mean age 65 years (range 60-69 years)] received high-dose chemotherapy followed by autologous stem cell transplantation. Partial small bowel resection has been performed in three patients. RESULTS: All four patients completed the mobilization and leucopheresis procedures successfully and subsequently received conditioning chemotherapy and transplantation. Engraftment occurred in all patients. No major non-haematological toxicity or transplantation-related mortality was observed. One patient has ongoing complete remission 32 months after transplantation. Three patients died from relapse within few months after autologous stem cell transplantation. CONCLUSIONS: Autologous stem cell transplantation seems unsatisfactory for patients with enteropathy-associated T-cell lymphoma. More intensive conditioning and aggressive chemotherapy with/or without targeted immunotherapy as well as allogenous stem cell transplantation needs to be explored
Al-Toma A, Visser OJ, van Roessel HM, von Blomberg BM, Verbeek WH, Scholten PE, Ossenkoppele GJ, Huijgens PC, Mulder CJ. Autologous hematopoietic stem cell transplantation in refractory celiac disease with aberrant T cells. NVGE voorjaarvergadering, maart, Veldhoven 2007;(abstract book):119.
Al-Toma A. Kennis over gecompliceerde coeliakie weer stap vooruit. Glutenvrij 2007;66-67.
Al-Toma A, Verbeek WH, Mulder CJ. Update on the management of refractory coeliac disease. Journal of Gastrointestinal & Liver Diseases 2007; 16(1):57-63.
Abstract: True Refractory Coeliac Disease (RCD) is being currently defined as persisting or recurring villous atrophy with crypt hyperplasia and increased intraepithelial lymphocytes in spite of a strict gluten free diet for more than 12 months or when severe persisting symptoms necessitate intervention independent of the duration of the dietary therapy. Currently two categories of RCD are being recognized: type I without aberrant T-cells and type II with aberrant T-cells detected by immunophenotyping by flowcytometric analysis or immunohistology of the intestinal mucosa. Establishing the diagnosis of RCD requires exclusion of other causes of villous atrophy and malignancies that may complicate coeliac disease. In contrast to patients with a high percentage of aberrant T cells, patients with RCD type I seem to profit from an immunosuppressive treatment. In cases of RCD II with persistent clinical symptoms and/or high percentage of aberrant T cells in intestinal biopsies in spite of a corticosteroid treatment, more aggressive therapeutic schemes should be considered. However, no therapy seems to be curative in RCD II. Cladribine (2-CDA) seems to have some role in the management of these patients. More recently, high dose chemotherapy followed by autologous stem cell transplantation has been used in patients resulting in a dramatic improvement in the clinical, laboratory, histopathological and immunological parameters. This review provides an overview of the currently available diagnostic and therapeutic methods in a complicated form of coeliac disease
Al-Toma A, Mulder CJ. Review article: Stem cell transplantation for the treatment of gastrointestinal diseases - current applications and future perspectives. Alimentary Pharmacology & Therapeutics 2007; 26 Suppl 2:77-89.
Abstract: BACKGROUND: Haematopoietic stem cell transplantation (HSCT) can be used to cure or ameliorate a variety of non-malignant diseases. These range from inherent defects of haematopoiesis, through metabolic diseases, to severe autoimmune diseases. The rationale for this strategy is based on the concept of immunoablation using high-dose chemotherapy, with subsequent regeneration of naive T-lymphocytes derived from reinfused haematopoietic progenitor cells. Possibly the use of SCT allows the administration of high-dose chemotherapy resulting in a prompt remission in these therapy-refractory patients. AIM: This review highlights the major scientific developments and defines the areas of successful use of HSCT in gastrointestinal disorders and gives a perspective on possible future applications. METHODS: A search in the Medline has been conducted and all relevant published data were analysed. RESULTS: HSCT has been proved successful in treating refractory Crohn's disease. A selected group of refractory coeliac patients having a high risk of developing enteropathy associated T-cell lymphoma has been recently treated with promising results. In cryptogenic cirrhosis, basic research and unpublished data concerning mesenchymal SCT are encouraging. CONCLUSION: In refractory autoimmune gastrointestinal diseases, it seems that high-dose chemotherapy followed by HSCT is feasible and safe and might result in long-term improvement of disease activity
Al-Toma A, Verbeek WH, Hadithi M, von Blomberg BM, Mulder CJ. Survival in refractory coeliac disease and enteropathy-associated T-cell lymphoma: retrospective evaluation of single-centre experience. Gut 2007; 56(10):1373-1378.
Abstract: BACKGROUND: Coeliac disease may be regarded as refractory disease (RCD) when symptoms persist or recur despite strict adherence to a gluten-free diet. RCD may be subdivided into types I and II with a phenotypically normal and aberrant intraepithelial T-cell population, respectively. RCD I seems to respond well to azathioprine/prednisone therapy. RCD II is usually resistant to any known therapy and transition into enteropathy-associated T-cell lymphoma (EATL) is common. AIM: To provide further insight into RCD and the development of EATL, by reporting on long-term survival and risk of transition of RCD into EATL in a large cohort of patients with complicated coeliac disease. Design and METHODS: Retrospective comparison of responses to therapy in four groups of patients with complicated coeliac disease: 43, RCD I; 50, RCD II (total), of whom 26 with RCD II developed EATL after a period of refractoriness to a gluten-free diet (secondary EATL) and 13 were EATL patients without preceding history of complicated coeliac disease (de novo EATL). RESULTS: No coeliac-disease-related mortality was recognised in the RCD I group. The overall 5-year survival in the RCD I group it was 96%; in the RCD II (total) group was 58%; and in the RCD II group after developing EATL it was only 8%. The 2-year survival in the de novo EATL group was 20% versus 15% in secondary EATL group (p = 0.63). Twenty-eight (56%) of the 50 patients with RCD II died, 23 (46%) due to EATL, 4 due to a progressive refractory state with emaciation and 1 from neurocoeliac disease. CONCLUSION: Remarkably, no patient with RCD I developed RCD II or EATL within the mean follow-up period of 5 years (range 2-15 years). A total of 52% of the RCD II patients developed EATL within 4-6 years after the diagnosis of RCD II. More aggressive and targeted therapies seem necessary in RCD II and EATL
Al-Toma A. Management of Complicated Coeliac Disease. Arab Journal of Gastroenterology 2007; 8(3):68-73.
Al-Toma A, Verbeek WH, Mulder CJ. The management of complicated celiac disease. Digestive Diseases 2007; 25(3):230-236.
Abstract: Refractory celiac disease (RCD) is being defined as persisting or recurring villous atrophy with crypt hyperplasia and increased intraepithelial lymphocytes (IELs) in spite of a strict gluten-free diet (GFD) for >12 months or when severe persisting symptoms necessitate intervention independent of the duration of the GFD. RCD may not respond primarily or secondarily to GFD. All other causes of malabsorption must be excluded and additional features supporting the diagnosis of CD must be looked for, including the presence of antibodies in the untreated state and the presence of celiac-related HLA-DQ markers. In contrast to patients with a high percentage of aberrant T-cells, patients with RCD I seem to profit from an immunosuppressive treatment. RCD II is usually resistant to medical therapies. Response to corticosteroid treatment does not exclude underlying enteropathy-associated T-cell lymphoma. Cladribine seems to have a role, although it is less than optimal in the treatment of these patients. It may be considered, however, as the only treatment thus far studied that showed significant reduction of aberrant T cells, seems to be well tolerated, and may have beneficial long-term effects in a subgroup of patients showing significant reduction of the aberrant T-cell population. Autologous stem cell transplantation (ASCT) seems promising in those patients with persisting high percentages of aberrant T cells. The first group of patients treated with ASCT showed improvement in the small intestinal histology, together with an impressive clinical improvement. However, it remains to be proven if this therapy delays or prevents lymphoma development. Copyright (c) 2007 S. Karger AG, Basel
Al-Toma A, Jacobs MAJM. Post-DBE pancreatitis. Case no. 61. In: Mulder CJJ, editor. Atlas of double-balloon endoscopy. 2007: 133.
Al-Toma A, Jacobs MAJM. Lipomatous polyp and recurrent small-bowel obstruction. Case no. 57. In: Mulder CJJ, editor. Atlas of double-balloon endoscopy. 2007: 126.
Al-Toma A, Jacobs MAJM. Retrieval of video capsules. Case no 55. In: Mulder CJJ, editor. Atlas of double-balloon endoscopy. 2007: 123.
Al-Toma A, Craanen ME, Jacobs MAJM. Idiopathic varicosis coli. Case no 27. In: Mulder CJJ, editor. Atlas of double-balloon endoscopy. 2007: 63.
Al-Toma A, Jacobs MAJM. ERCP via DBE. Case no. 64. In: Mulder CJJ, editor. Atlas of double-balloon endoscopy. 2007: 140.
Al-Toma A-B. Complicated Coeliac Disease : Diagnosis and Management. Amsterdam: Vrije Universiteit, 2007.
Alipour A, van Oostrom AJ, van Wijk JP, Verseyden C, Plokker HW, Jukema JW, Rabelink AJ, Cabezas MC. Abstract 1098: Deficiency of Mannose Binding Lectin is Associated with Increased Postprandial VLDL1 Despite Normal Fasting Plasma Triglycerides. Circulation 2007; 116(16 suppl):II-220.
Allegaert K, Peeters MY, Verbesselt R, Tibboel D, Naulaers G, de Hoon JN, Knibbe CA. Inter-individual variability in propofol pharmacokinetics in preterm and term neonates. British Journal of Anaesthesia 2007; 99(6):864-870.
Abstract: BACKGROUND: /st> To document covariates which contribute to inter-individual variability in propofol pharmacokinetics in preterm and term neonates. METHODS: /st> Population pharmacokinetics were estimated (non-linear mixed effect modelling) based on the arterial blood samples collected in (pre)term neonates after i.v. bolus administration of propofol (3 mg kg(-1), 10 s). Covariate analysis included postmenstrual age (PMA), postnatal age (PNA), gestational age, weight, and serum creatinine. RESULTS: /st> Two hundred and thirty-five arterial concentration-time points were collected in 25 neonates. Median weight was 2930 (range 680-4030) g, PMA 38 (27-43) weeks, and PNA 8 (1-25) days. In a three-compartment model, PMA was the most predictive covariate for clearance (P<0.001) when parameterized as [CL(std).(PMA/38)(11.5)]. Standardized propofol clearance (CL(std)) at 38 weeks PMA was 0.029 litre min(-1). The addition of a fixed value in neonates with a PNA of >/=10 days further improved the model (P<0.001) and resulted in the equation [CL(std).(PMA/38)(11.5) +0.03] for neonates >/=10 days. Values for central volume (1.32 litre), peripheral volume 1 (15.4 litre), and peripheral volume 2 (1.29 litre) were not significantly influenced by any of the covariates (P>0.001). CONCLUSIONS: /st> PMA and PNA contribute to the inter-individual variability of propofol clearance with very fast maturation of clearance in neonatal life. This implicates that preterm neonates and neonates in the first week of postnatal life are at an increased risk for accumulation during either intermittent bolus or continuous administration of propofol
Arend SM, Thijsen SF, Leyten EM, Bouwman JJ, Franken WP, Koster BF, Cobelens FG, van Houte AJ, Bossink AW. Comparison of Two Interferon-γ Assays and Tuberculin Skin Test for Tracing Tuberculosis Contacts. American Journal of Respiratory & Critical Care Medicine 2007; 175(6):618-627.
Abstract: Background: The tuberculin skin test (TST) has low specificity. QuantiFERON-TB Gold (QFT-G) and T-SPOT.TB are based on interferon (IFN)-gamma responses to Mycobacterium tuberculosis-specific antigens. A novel in-tube format of QFT-G (QFT-GIT) offers logistical advantages. Objective: To compare TST, QFT-GIT, and T-SPOT.TB in bacillus Calmette-Guerin unvaccinated contacts and correlate results with measures of recent exposure. Methods: When a supermarket employee with smear-positive tuberculosis had infected most close contacts, a contact investigation among more than 20,000 customers was performed. We recruited subjects randomly on the day of TST administration (n = 469) and subjects with TST of more than 0 mm on the day of TST reading (n = 316). QFT-GIT and T-SPOT.TB were performed. Demographic data and measures of exposure were collected. TST results were analyzed at a cutoff of 10 or 15 mm. Blood tests were interpreted following the manufacturers' criteria and by varying cutoff levels. Results: Among 785 study participants, TST results were associated with age, whereas positive IFN-gamma responses were significantly associated with cumulative shopping time, most markedly for QFT-GIT. Among participants with a TST of 15 mm or greater, sensitivity of QFT-GIT and T-SPOT.TB was 42.2 and 51.3%, respectively. Interassay agreement was 89.6% (kappa = 0.59). By varying cutoff values, agreement between the IFN-gamma assays was optimal at 93.6% (kappa = 0.71) using a cutoff of 0.20 IU/ml for QFT-GIT and 13 spots for T-SPOT.TB. Conclusions: Blood test results were associated with exposure, whereas the TST was not. A possible lack of sensitivity of IFN-gamma assays in detecting individuals with TST of 15 mm or greater, despite negative bacillus Calmette-Guerin vaccination status, warrants further investigation into alternative cutoff values
Backus BE, Lenderink T, Six AJ. Old inferior wall infarction? Netherlands Heart Journal 2007; 15(7/8):271-272, 277.
Bakema M. Vergeving en exoneratie : werken aan het helen van relaties, als heil voor heden en toekomst. In: Thans M, editor. Uit betrouwbare bronnen : de pastorale praktijk vanuit contextuele optiek. Zoetermeer: Uitgeverij Meinema, 2007: 142-159.
Balemans WAF. Luchtweginfecties op kinderleeftijd en allergische ziekte later. Nederlands Tijdschrift voor Allergie 2007; 7(1):31-33.
Beckers M, Verzijlbergen F, Tiel-van Buul M, Prins M, Biesma D. The value of pet- scanning in the detection of occult cancer in patients with venous thromboembolism. Journal of Thrombosis & Haemostasis 2007; 5(Suppl 2):P-S-550.
Beckers M, Ruven H, Prins M, Biesma D. Il 1a –899c/t and il4 –589c/t are associated with venous thromboembolism. Journal of Thrombosis & Haemostasis 2007; 5(Suppl 2):P-M-488.
Beckers MM, Slee PH. Hypercalcaemia in a patient with a gastrointestinal stromal tumour. Clinical Endocrinology 2007; 66(1):148.
Becking AG, Zijderveld SA, Tuinzing DB. The surgical management of post-traumatic malocclusion. Clinics in Plastic Surgery 2007; 34(3):e37-e43.
Abstract: Facial skeleton fractures should be reduced as early as possible to restore optimal function and minimize skeletal and soft-tissue deformity. With unsatisfactory outcome from delayed treatment because of comorbidity, or despite optimal management, late reconstruction can succeed with conventional orthognathic surgical procedures. Management follows well-established principles of correcting dentofacial deformities, coordinated with orthodontic and prosthodontic support. Planning should include dental records when available, and clinical photographs. The late deformity of midfacial fractures can be corrected by following initial fracture lines; condylar fracture patients can be treated by remote osteotomies. Before surgical intervention, diminished temporomandibular joint (TMJ) mobility should be managed with aggressive physiotherapy to maximize stomal opening. Additionally, successful outcome will depend on a stable TMJ relation without ongoing remodeling
Besselink MG, van Santvoort HC, Witteman BJ, Gooszen HG, for the Dutch Acute Pancreatitis Study Group. Management of severe acute pancreatitis: it's all about timing. Current Opinion in Critical Care 2007; 13(2):200-206.
Abstract: PURPOSE OF REVIEW: This study provides an update on the treatment of severe acute pancreatitis (SAP) with emphasis on nutrition, infection-prophylaxis, biliary pancreatitis, surgical intervention and new randomized controlled trials. RECENT FINDINGS: The most relevant new insights are: (i) early enteral nutrition in SAP is not only capable of reducing infectious complications but may also reduce mortality; (ii) there is increasing evidence that antibiotic-prophylaxis is not capable of preventing infectious complications in SAP; (iii) probiotic-prophylaxis is being considered as an alternative with promising experimental results; (iv) in biliary pancreatitis, early endoscopic retrograde cholangiography with sphincterotomy (within 48 h) is beneficial in case of ampullary obstruction, although it may be withheld in the event of negative endoscopic ultrasound; (v) surgical intervention for infected (peri-)pancreatic necrosis is increasingly being postponed; (vi) minimally invasive strategies are being considered as a full alternative for necrosectomy by laparotomy in infected (peri-)pancreatic necrosis; (vii) the Atlanta classification should no longer be used to describe computed tomography findings in acute pancreatitis; and (viii) only five randomized controlled trials of patients with acute pancreatitis are currently registered in the international trial registries. SUMMARY: Timing of intervention is becoming increasingly important in SAP management
Besselink MG, Verwer TJ, Schoenmaeckers EJ, Buskens E, Ridwan BU, Visser MR, Nieuwenhuijs VB, Gooszen HG. Timing of surgical intervention in necrotizing pancreatitis. Archives of surgery 2007; 142(12):1194-1201.
Abstract: OBJECTIVE: To determine the effect of timing of surgical intervention for necrotizing pancreatitis. DESIGN: Retrospective study of 53 patients and a systematic review. SETTING: A tertiary referral center. Main Outcome Measure Mortality. RESULTS: Median timing of the intervention was 28 days. Eighty-three percent of patients had infected necrosis and 55% had preoperative organ failure. The mortality rate was 36%. Sixteen patients were operated on within 14 days of initial admission, 11 patients from day 15 to 29, and 26 patients on day 30 or later. This latter group received preoperative antibiotics for a longer period (P < .001), and Candida species and antibiotic-resistant organisms were more often cultured from the pancreatic or peripancreatic necrosis in these patients (P = .02). The 30-day group also had the lowest mortality (8% vs 75% in the 1 to 14-days group and 45% in the 15 to 29-days group, P < .001); this difference persisted when outcome was stratified for preoperative organ failure. During the second half of the study, necrosectomy was further postponed (43 vs 20 days, P = .06) and mortality decreased (22% vs 47%, P = .09). We also reviewed 11 studies with a total of 1136 patients. Median surgical patient volume was 8.3 patients per year (range, 5.3-15.6), median timing of surgical intervention was 26 days (range, 3-31), and median mortality was 25% (range, 6%-56%). We observed a significant correlation between timing of intervention and mortality (R = - 0.603; 95% confidence interval, - 2.10 to - 0.02; P = .05). CONCLUSION: Postponing necrosectomy until 30 days after initial hospital admission is associated with decreased mortality, prolonged use of antibiotics, and increased incidence of Candida species and antibiotic-resistant organisms
Besselink MG, Bollen TL, Scheffer RC, Weusten BL, Timmer R, Wiezer RM, van Ramshorst B. Rupture of infected peripancreatic necrosis to the peritoneal cavity with fatal outcome. Pancreas 2007; 34(4):477-479.
Besselink MG, van Santvoort HC, Schaapherder AF, van Ramshorst B, van Goor H, Gooszen HG. Feasibility of minimally invasive approaches in patients with infected necrotizing pancreatitis. British Journal of Surgery 2007; 94(5):604-608.
Abstract: BACKGROUND:: Minimally invasive procedures to treat infected necrotizing pancreatitis (INP) are gaining popularity. The proportion of patients suitable for this approach remains unknown. METHODS:: Preoperative computed tomography (CT) scans were reviewed from 106 consecutive patients who had surgery for INP between 2000 and 2003 in 11 Dutch hospitals. Collections related to the pancreas were classified according to their distance from the left abdominal wall. Five radiologists judged 'accessibility' for drain placement and the likelihood that there was a fluid component that would drain ('drainability'). Agreement between radiologists was determined. RESULTS:: CT scans of 80 (75 per cent) patients were available (59 men; age range 29-80 years). The median interval between hospital admission and preoperative CT scan was 20 days. In 55 (69 per cent) patients, the lateral border of the collection was less than 5 cm from the left abdominal wall. Placement of a drain was deemed feasible in 67 (84 (range 77-89) per cent) patients; mean(s.d.) kappa 0.428(0.096). In 45 (56 per cent) patients, a drain could be placed through the left retroperitoneum. In 43 (54 (range 49-82) per cent) patients, collections were judged to contain a drainable fluid component. Interobserver agreement on 'drainability' was poor, mean(s.d.) kappa 0.289(0.101). CONCLUSION:: Most peripancreatic collections in INP were considered accessible to a minimally invasive approach. Copyright (c) 2007 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd
Besselink MG, van Santvoort HC, Carter R, Charnley R, Mole DJ, Gooszen HG. Designing an optimal study for the management of infected pancreatic necrosis. In: Imrie C, Johnson C, editors. Pancratic disease : the challenges. New York: Springen, 2007.
Bestebreurtje P, Knibbe CAJ, de Wildt SN, Tibboel D, van Sorge AA. Rectale formulering omeprazol voor kinderen jonger dan een half jaar met pathologische gastro-oesofageale reflux. PW Wetenschappelijk Platform 2007; 1(3):wp64-wp68.
Biemans JMA, Smeets L, Kelder JC, van Heesewijk JPM, Moll FL, Teijink JAW. Optimale positie van de patient bij katheterizatie van de V. subclavia: in trendelenburgligging, zonder rol tussen de schouderbladen. Nederlands Tijdschrift voor Geneeskunde 2007; 151(4):243-247.
Biemond-Moeniralam HS, Meinders AJ, Bras LJ. Compliance with the surviving sepsis guidelines and outcome. 19e Internistendagen : abstractboek :25, 26 & 27 april 2007 MECC Maastricht 2007;15-16.
Biemond-Moeniralam HS. De mortaliteit van hartfalen patiënten zonder diabetes is geassocieerd met de glucose spiegel bij opname. Nederlands Tijdschrift voor Geneeskunde 2007.
Biesma DH, Lokhorst HM, van der Hem K, van der Heul C. An Observational Post Authorization Study on the Use of Bortezomib in Multiple Myeloma Patients in The Netherlands: Results of an Interim Analysis. Blood 2007; 110(11 (ASH Annual Meeting Abstracts)):4808.
Blanchard D, Danzi GB, Urban P, Moseri M, Juergens C, Guyon P, Nowak B, Tresukosol D, Suttorp MJ, Farshid A, Kornowski R, Garcia E, Yeend R, Nagai H, Paunovic D, on behalf of MATSURI investigators. A novel ultra-thin bare metal stent (BMS): results from a worldwide registry. EuroIntervention 2007; 3:1-17.
Boer K, Nellen JF, Patel D, Timmermans S, Tempelman C, Wibaut M, Sluman MA, van der Ende ME, Godfried MH. The AmRo study: pregnancy outcome in HIV-1-infected women under effective highly active antiretroviral therapy and a policy of vaginal delivery. BJOG 2007; 114(2):148-155.
Abstract: OBJECTIVE: To explore pregnancy outcome in HIV-1-positive and HIV-negative women, and mother-to-child transmission (MTCT) according to mode of delivery under effective highly active antiretroviral therapy (HAART). DESIGN: Cohort of 143 pregnant HIV-1-infected women including a matched case-control study in a 2:1 ratio of controls to cases (n=98). SETTING: Academic Medical Center in Amsterdam and Erasmus Medical Center in Rotterdam, the Netherlands. POPULATION: Consecutive referred HIV-1 infected pregnant women treated with HAART and matched control not infected pregnant women. MAIN OUTCOME MEASURES: MTCT, preterm delivery, low birthweight, pre-eclampsia. RESULTS: MTCT was 0% (95% CI 0-2.1%). Seventy-eight percent of HIV-1-infected women commenced and 62% completed vaginal delivery. The calculated number of caesarean sections needed to prevent a single MTCT was 131 or more. Preterm delivery rates were 18% (95% CI 11-27) in women infected with HIV-1 and 9% (95% CI 5-13) in controls (P=0.03). HAART used at <13 weeks of gestation was associated with a 44% preterm delivery rate compared with 21% when HAART was started at or after 13 weeks and 14% in controls. (Very) low birthweight and incidence of pre-eclampsia were not different between HIV-1 and controls. CONCLUSIONS: We have not demonstrated any MTCT after vaginal delivery in women effectively treated by HAART. The HAART-associated increase in preterm delivery rate is mainly seen after first trimester HAART use
Boers KE, Bijlenga D, Mol BW, LeCessie S, Birnie E, van Pampus MG, Stigter RH, Bloemenkamp KW, van Meir CA, van der Post JA, Bekedam DJ, Ribbert LS, Drogtrop AP, van der Salm PC, Huisjes AJ, Willekes C, Roumen FJ, Scheepers HC, de Boer K, Duvekot JJ, Thornton JG, Scherjon SA. Disproportionate Intrauterine Growth Intervention Trial At Term: DIGITAT. BMC Pregnancy & Childbirth 2007; 7:12.
Abstract: ABSTRACT: BACKGROUND: Around 80% of intrauterine growth restricted (IUGR) infants are born at term. They have an increase in perinatal mortality and morbidity including behavioral problems, minor developmental delay and spastic cerebral palsy. Management is controversial, in particular the decision whether to induce labour or await spontaneous delivery with strict fetal and maternal surveillance. We propose a randomised trial to compare effectiveness, costs and maternal quality of life for induction of labour versus expectant management in women with a suspected IUGR fetus at term. METHODS/DESIGN: The proposed trial is a multi-centre randomised study in pregnant women who are suspected on clinical grounds of having an IUGR child at a gestational age between 36+0 and 41+0 weeks. After informed consent women will be randomly allocated to either induction of labour or expectant management with maternal and fetal monitoring. Randomisation will be web-based. The primary outcome measure will be a composite neonatal morbidity and mortality. Secondary outcomes will be severe maternal morbidity, maternal quality of life and costs. Moreover, we aim to assess neurodevelopmental and neurobehavioral outcome at two years as assessed by a postal enquiry (Child Behavioral Check List-CBCL and Ages and Stages Questionnaire-ASQ). Analysis will be by intention to treat. Quality of life analysis and a preference study will also be performed in the same study population. Health technology assessment with an economic analysis is part of this so called Digitat trial (Disproportionate Intrauterine Growth Intervention Trial At Term). The study aims to include 325 patients per arm. DISCUSSION: This trial will provide evidence for which strategy is superior in terms of neonatal and maternal morbidity and mortality, costs and maternal quality of life aspects. This will be the first randomised trial for IUGR at term. TRIAL REGISTRATION: Dutch Trial Register and ISRCTN-Register: ISRCTN10363217
Boersma L, van Boven W, Wever E, Defauw J. Thoracoscopic bipolar RF isolation of the pulmonary veins as treatment for atrial fibrillation. ESC 2007.
Boersma LVA. T-wave alternans: predicting the unpredictable? European Heart Journal 2007; 28(19):2303-2304.
Bollen TL, van Santvoort HC, Besselink MG, van Es HW, Gooszen HG, van Leeuwen MS. Update on acute pancreatitis: ultrasound, computed tomography, and magnetic resonance imaging features. Seminars in Ultrasound, CT & MR 2007; 28(5):371-383.
Abstract: Imaging of patients with acute pancreatitis requires an understanding of the subtypes and complications that were defined at the Atlanta symposium in 1992. In the last decade, several new entities have been recognized with important clinical implications. In this article, the radiological aspects of the terminology and classification of acute pancreatitis are reviewed and new entities are clarified. The roles of ultrasound, computed tomography, and magnetic resonance imaging in the diagnosis and evaluation of acute pancreatitis and its complications are discussed and the limitations of each imaging technique, when interpreting pancreatic and peripancreatic inflammatory disease, are addressed
Bollen TL, van Santvoort HC, Besselink MG, van Ramshorst B, van Es HW, Gooszen HG, Dutch Acute Pancreatitis Study Group. Intense adrenal enhancement in patients with acute pancreatitis and early organ failure. Emergency Radiology 2007; 14(5):317-322.
Abstract: Intense adrenal enhancement has previously been reported in patients with hypovolemic and septic shock. The purpose of this study was to assess whether this computed tomography (CT) finding is also observed in patients presenting with severe acute pancreatitis and early organ failure. A retrospective analysis of a prospectively collected database was performed. Out of 38 consecutive patients with predicted severe acute pancreatitis, 3 patients showed intense bilateral adrenal enhancement on early CT. All patients had early multiple organ failure and subsequently died. In two cases, pathologic correlation was obtained. Intense adrenal enhancement may be a new prognostic indicator in patients with acute pancreatitis, particularly when organ failure is present at the time of CT examination. Further studies are necessary to confirm this observation
Bollen TL, Besselink MG, van Santvoort HC, Gooszen HG, van Leeuwen MS. Toward an update of the Atlanta classification on acute pancreatitis: review of new and abandoned terms. Pancreas 2007; 35(2):107-113.
Abstract: OBJECTIVES: The 1992 Atlanta classification is a clinically based classification system that defines the severity and complications of acute pancreatitis. The purpose of this review was to assess whether the terms abandoned by the Atlanta classification are really discarded in the literature. The second objective was to review what new terms have appeared in the literature since the Atlanta symposium. METHODS: We followed a Medline search strategy in review and guideline articles after the publication of the Atlanta classification. This search included the abandoned terms: "phlegmon," "infected pseudocyst," "hemorrhagic pancreatitis," and "persistent pancreatitis." RESULTS: A total of 239 publications were reviewed, including 10 guideline articles and 42 reviews. The abandoned terms "hemorrhagic pancreatitis" and "persistent pancreatitis" are hardly encountered, in contrast, both "infected pseudocyst" and "phlegmon" are frequently used, and several authors question their abandonment. New terminology in acute pancreatitis consists of "organized pancreatic necrosis," "necroma," "extrapancreatic necrosis," and "central gland necrosis." CONCLUSIONS: This review demonstrates that the Atlanta classification is still not universally accepted. Several abandoned terms are frequently used, and new terms have emerged that describe manifestations in acute pancreatitis that were not specifically addressed during the Atlanta symposium
Boonstra A, Snijder RJ. Stoornissen in de pulmonale circulatie. In: van den Bosch JMM, Bottema BJAM, Lammers J-WJ, Zaagsma J, editors. Het pulmonaal formularium : een praktische leidraad. Houten: Bohn Stafleu Van Loghum, 2007: 164-182.
Borghuis TL, Bos WJW, Geers AB, Siegers HP, Steenhoff AMT, Muis G, de Wit M, Andrea G. Vertragingen te lijf : drastische verkorting van opnameduur in St. Antonius Ziekenhuis. Medisch Contact 2007; 62(33/34):1366-1369.
Bos WJ, Verrij EA, Vincent HH, Westerhof BE, Parati G, van Montfrans GA. Thumb-rule for the proper assessment of mean blood pressure at the brachial artery level: what should be changed? Journal of Hypertension 2007; 25(8):1741-1742.
Bos WJ, Verrij EA, Vincent HH, Westerhof BE, Parati G, van Montfrans GA. How to assess mean blood pressure properly at the brachial artery level. Journal of Hypertension 2007; 25(4):751-755.
Bossema E, Brand N, Moll F, Ackerstaff R, van Doornen L. Testing the laterality hypothesis after left or right carotid endarterectomy: no ipsilateral effects on neuropsychological functioning. Journal of Clinical & Experimental Neuropsychology 2007; 29(5):505-513.
Abstract: Carotid endarterectomy (CEA) is performed to prevent stroke, but the possible restorative function of CEA on neuropsychological functioning has frequently been considered. Restorative effects might be clearer in functions mediated by the hemisphere ipsilateral to the operated side than in those of the contralateral hemisphere. The present study examined this hypothesis, both at group level and at individual level, in 45 right-handed male patients with CEA of either the right or the left carotid artery. Patients with a clinically presented stroke were excluded. Only tasks sensitive to hemispheric specialization were included. Preoperatively, the two patient subgroups performed significantly worse than the healthy control group in the planning of motor behavior, verbal fluency, and visual recognition. Three months after surgery, the mean performance of the patient group increased only in left-hand finger tapping. This was irrespective of the side of surgery and could be attributed to practice. In addition, the number of patients with meaningful cognitive change did not differ between the group with right-sided CEA and the group with left-sided CEA. In conclusion, ipsilateral effects on neuropsychological functioning after CEA were not demonstrated, although instruments and sample characteristics were optimal in light of hemispheric functional asymmetry
Braam RL, van Uum SH, Lenders JW, Thien T. Geen reactie op antihypertensieve therapie: denk aan therapieontrouw. Nederlands Tijdschrift voor Geneeskunde 2007; 151(10):569-573.
Abstract: In 3 patients, 2 men aged 62 and 43 years, respectively, and 1 woman aged 53 years, the medication prescribed to reduce blood pressure was insufficiently effective. Drug adherence was questioned. The first patient was afraid of the side effects mentioned in the medication information leaflet. The second patient had insufficient plasma levels of the medication but would not discuss the subject. The blood pressure of the third patient was uncontrolled despite treatment with three antihypertensive drugs. During a short hospital stay, her blood pressure responded favourably to treatment with only one of the three drugs. Subsequent repeated instruction did not improve her situation. Drug adherence is an important issue in daily clinical practice. In patients with asymptomatic conditions like hypertension, adherence is expected to be poor and worsen over time. Adherence is very difficult to measure. Risk factors for poor adherence include complex medication schedules, multiple dosing times, depression and real or suspected side effects. Measures to improve drug adherence include simplifying the medication schedule, discussing the schedule during check-ups, using automated blood pressure measuring devices at home, maintaining e-mail contact with the patient and involving a specialised nurse. Increased awareness of poor adherence is an important step toward improving hypertension treatment
Braam RL. Methodological aspects of blood pressure measurement and adherence to antihypertensive drug therapy. Enschede: Gildeprint Drukkerijen B.V., 2007.
Bras LJ. Cardioanesthesie. In: Hennis PJ, Leusink JA, editors. Anesthesiologie. Houten: Bohn Stafleu Van Loghum, 2007: 449-462.
Bredenoord AJ, Smout AJPM. High-resolution manometry of the esophagues: more than a colorful view on esophageal motility? Expert Rev Gastroentrol Hepatol 2007; 1(1):61-68.
Bredenoord AJ. Boeren en hikken. In: Muris JWM, Mathus-Vliegen EMH, Voorn ThB, editors. Gastro-enterologie. Houten: Bohn Stafleu van Loghum, 2007: 159-167.
Bredenoord AJ, Tutuian R, Smout AJ, Castell DO. Technology review: Esophageal impedance monitoring. American Journal of Gastroenterology 2007; 102(1):187-194.
Abstract: Intraluminal impedance monitoring is a new technique that can be used to detect the flow of liquids and gas through hollow viscera. In combination with manometry, it is used for esophageal function testing and while manometry provides information on contractile activity, impedance provides information on esophageal bolus transit. This is especially useful in patients with nonobstructive dysphagia. However, impedance monitoring appears to be less suitable for the evaluation of patients with achalasia. When used in combination with esophageal pH monitoring, impedance monitoring makes gastroesophageal reflux monitoring more complete because it allows recognition of both acidic and weakly acidic reflux episodes. The results of several studies suggest that impedance-pH monitoring is useful in the evaluation of patients with PPI-resistant typical reflux symptoms, chronic unexplained cough, excessive belching, and rumination
Bredenoord AJ, Dent J. Proton pump inhibitor-therapy refractory gastro-oesophageal reflux disease patients, who are they? Gut 2007; 56(4):593-594.
Bredenoord AJ. High-resolution manometry : bliss upon bliss for esophagology? European Surgery 2007; 39(3):167-173.
Bredenoord AJ, Smout AJPM. Physiologic and Pathologic Belching. Clinical Gastroenterology & Hepatology 2007; 5(7):772-775.
Bredenoord AJ, Onaca GM, van Ramshorst B, Biesma DH. Sigmoid carcinoma as long term complication after ureterosigmoidostomy. 19e Internistendagen : abstractboek :25, 26 & 27 april 2007 MECC Maastricht 2007;30-31.
Bruggink AH, van Oosterhout MF, de Jonge N, Cleutjens JP, van Wichen DF, van Kuik J, Tilanus MG, Gmelig-Meyling FH, van den Tweel JG, de Weger RA. Type IV collagen degradation in the myocardial basement membrane after unloading of the failing heart by a left ventricular assist device. Laboratory Investigation 2007; 87(11):1125-1137.
Abstract: After left ventricular assist device (LVAD) support in patients with end-stage cardiomyopathy, cardiomyocytes decrease in size. We hypothesized that during this process, known as reverse remodeling, the basement membrane (BM), which is closely connected to, and forms the interface between the cardiomyocytes and the extracellular matrix, will be severely affected. Therefore, the changes in the myocardial BM in patients with end-stage heart failure before and after LVAD support were studied. The role of MMP-2 in this process was also investigated. Transmission electron microscopy showed that the BM thickness decreased post-LVAD compared to pre-LVAD. Immunohistochemistry indicated a reduced immunoreactivity for type IV collagen in the BM after LVAD support. Quantitative PCR showed a similar mRNA expression for type IV collagen pre- and post-LVAD. MMP-2 mRNA almost doubled post-LVAD (P<0.01). In addition, active MMP-2 protein as identified by gelatin zymography and confirmed by Western blot analysis was detected after LVAD support and in controls, but not before LVAD support. Active MMP was localized in the BM of the cardiomyocyte, as detected by type IV collagen in situ zymography. Furthermore, in situ hybridization/immunohistochemical double staining showed that MMP-2 mRNA was expressed in cardiomyocytes, macrophages, T-cells and endothelial cells. Taken together, these findings show reduced type IV collagen content in the BM of cardiomyocytes after LVAD support. This reduction is at least in part the result of increased MMP-2 activity and not due to reduced synthesis of type IV collagen.Laboratory Investigation advance online publication, 17 September 2007; doi:10.1038/labinvest.3700670
Brunnekreef GB, Heijmen RH, Gerritsen WB, Schepens MA, ter Beek HT, van Dongen EP. Measurements of Cerebrospinal Fluid Concentrations of S100ß Protein During and After Thoracic Endovascular Stent Grafting. European Journal of Vascular & Endovascular Surgery 2007; 34(2):169-172.
Calabresi PA, Giovannoni G, Confavreux C, Galetta SL, Havrdova E, Hutchinson M, Kappos L, Miller DH, O'Connor PW, Phillips JT, Polman CH, Radue EW, Rudick RA, Stuart WH, Lublin FD, Wajgt A, Weinstock-Guttman B, Wynn DR, Lynn F, Panzara MA, for the AFFIRM and SENTINEL Investigators, Frequin ST, Siegers HP, Mauser HW. The incidence and significance of anti-natalizumab antibodies: results from AFFIRM and SENTINEL. Neurology 2007; 69(14):1391-1403.
Abstract: OBJECTIVE: To determine the incidence and clinical effects of antibodies that develop during treatment with natalizumab. METHODS: In two randomized, double-blind, placebo-controlled studies (natalizumab safety and efficacy in relapsing remitting multiple sclerosis [MS, AFFIRM] and safety and efficacy of natalizumab in combination with interferon beta-1a [INF beta]1a] in patients with relapsing remitting MS [SENTINEL]) of patients with relapsing multiple sclerosis, blood samples were obtained at baseline and every 12 weeks to determine the presence of antibodies against natalizumab. Antibodies to natalizumab were measured using an ELISA. Patients were categorized as "transiently positive" if they had detectable antibodies (>or=0.5 microg/mL) at a single time point or "persistently positive" if they had antibodies at two or more time points >or=6 weeks apart. RESULTS: In the AFFIRM study, antibodies were detected in 57 of 625 (9%) of natalizumab-treated patients: Twenty (3%) were transiently positive and 37 (6%) were persistently positive. Persistently positive patients showed a loss of clinical efficacy as measured by disability progression (p <or= 0.05), relapse rate (p = 0.009), and MRI (p <or= 0.05) compared with antibody-negative patients. In transiently positive patients, full efficacy was achieved after approximately 6 months of treatment, the time when patients were becoming antibody negative. The incidence of infusion-related adverse events was significantly higher in persistently positive patients. Results of SENTINEL were similar to AFFIRM, except with regard to sustained disability progression; differences between persistently positive and antibody-negative patients were not statistically significant. CONCLUSIONS: The incidence of persistent antibody positivity associated with natalizumab is 6%. Reduced clinical efficacy is apparent in persistently positive patients. Patients with a suboptimal clinical response or persistent infusion-related adverse events should be considered for antibody testing
Collard S, Grutters J, Rensing B, Boersma L, Verzijlbergen J, van den Bosch J. Diagnosis of cardiac sarcoidosis: experience of a Dutch center. American Journal of Respiratory & Critical Care Medicine 2007; 175:A360.
Collard SM, Grutters JC, Verzijlbergen JF, Cramer MJM, Seldenrijk CA, de Bruin PC, Rensing BJWM, van den Bosch JMM. Cardiale sarcoïdose : een kardinale diagnose. Hart Bulletin 2007; 38(2):39-44.
Conchillo JM, Selimah M, Bredenoord AJ, Samsom M, Smout AJ . Air swallowing, belching, acid and non-acid reflux in patients with functional dyspepsia. Alimentary Pharmacology & Therapeutics 2007; 25(8):965-971.
Abstract: BACKGROUND: Frequent belching is a common symptom in patients with functional dyspepsia with a reported incidence up to 80%. We hypothesized that patients with functional dyspepsia possibly have a higher frequency of belching than healthy subjects secondary to frequent air swallowing. AIM: To assess air swallowing, belching, acid and non-acid reflux patterns of patients with functional dyspepsia. METHODS: Combined 24-h oesophageal impedance and pH monitoring was performed in 10 functional dyspepsia patients and 10 controls. Analysis of the impedance-pH signals included incidence of air swallows, belching, acid and non-acid reflux. RESULTS: The incidence of air swallows in functional dyspepsia patients were significantly higher compared with controls (153 +/- 15 vs. 79 +/- 10, P < 0.001), while the incidence of liquid-only swallows were not significantly increased. The proportions of gas-containing reflux episodes (belches) and non-acid reflux episodes in functional dyspepsia patients were significantly higher when compared with controls (66.4 vs. 44.4%, P = 0.04 and 70.1 vs. 45.9%, P = 0.009, respectively). CONCLUSION: Patients with functional dyspepsia swallow air more frequently than controls and this is associated with an increased incidence of non-acid gaseous gastro-oesophageal reflux
Copper MP, Triesscheijn M, Tan IB, Ruevekamp MC, Stewart FA. Photodynamic therapy in the treatment of multiple primary tumours in the head and neck, located to the oral cavity and oropharynx. Clinical Otolaryngology 2007; 32(3):185-189.
Abstract: Objectives: Multiple primary tumours are a common problem in the head and neck cancer patients. Curative surgery or radiotherapy of these tumours can be very mutilating or even impossible. This study aims at evaluating meta-tetrahydroxy-phenyl chlorin-mediated photodynamic therapy for second or multiple primary tumours in the head and neck. Design: Retrospective study of all patients with second or multiple primary tumours treated by photodynamic therapy over a 10-year period. Setting: All patients were treated in the Netherlands Cancer Institute, a tertiary referral centre for the head and neck cancer patients. Participants: A total of 27 patients with 42 the second or the multiple primary head and neck tumours were treated by photodynamic therapy (0.15 mg/kg meta-tetrahydroxy-phenyl chlorin). Main outcomes measures: Cure rates. Results: Twenty-eight of 42 tumours were cured (67%). Cure rates for stage I or in situ disease were 85%versus 38% for stage II/III. Conclusions: Cure rates for photodynamic therapy of the multiple primary head and neck tumours were lower than previously described for first primaries, but were still very encouraging for this difficult patient population. The high cure rate obtained in stage I multiple primaries emphasises the importance of a meticulous follow-up of patients treated for the head and neck cancer to detect new tumours at a curable stage
Damoiseaux J, Rijkers G, Tervaert JW. Pneumococcal vaccination does not increase circulating levels of IgM antibodies to oxidized LDL in humans and therefore precludes an anti-atherogenic effect. Atherosclerosis 2007; 190(1):10-11.
Darquennes K, van den Boogaard M, van Swieten HA, Duurkens VA, Grutters JC. A rare cause of spontaneous pneumothorax after lifesaving pneumonectomy in a patient with sarcoidosis. Sarcoidosis Vasculitis & Diffuse Lung Diseases 2007; 24(1):77-78.
de Borst GJ, Vos JA, Reichmann B, Hellings WE, de Vries JP, Suttorp MJ, Moll FL, Ackerstaff RG, on behalf of the Antonius Carotid Endaterectomy Angioplasty and Stenting Study Group. The Fate of the External Carotid Artery after Carotid Artery Stenting. A Follow-up Study with Duplex Ultrasonography. European Journal of Vascular & Endovascular Surgery 2007; 33(6):657-663.
Abstract: OBJECTIVE: To evaluate the long-term effect of carotid angioplasty and stenting (CAS) of the internal carotid artery (ICA) on the ipsilateral external carotid artery (ECA). SUBJECTS AND METHODS: We prospectively registered the pre- and post-interventional duplex scans obtained from 312 patients (mean age 70 years) who underwent CAS. Duplex scans were scheduled the day before CAS, 3 and 12 months post-procedurally and yearly thereafter, to study progression of obstructive disease in the ipsilateral ECA compared to the contralateral ECA. The duplex ultrasound criteria used to identify ECA stenosis >/=50% were Peak Systolic Velocities of >/=125cm/s. RESULTS: Preprocedural evaluation of the ipsilateral ECA demonstrated >/=50% stenosis in 32.7% of cases vs 30% contralateral. Both ipsilateral and contralateral 3 (1%) ECA occlusions were noted. After stenting 5 (1.8%) occlusions were seen vs 1% contralateral. No additional ipsilateral occlusions and 2 additional contralateral oclusions were noted at extended follow-up. The prevalence of >/=50% stenosis of the ipsilateral ECA (Kaplan-Meier estimates) progressed from 49.1% at 3, to 56.4%, 64.7%, 78.2%, 72.3%, and 74% at 12, 24, 36, 48, and 60 months respectively. Contralateral prevalences were 31.3%, 37.7%, 41.7%, 43.1%, 46.0%, and 47.2% respectively (p<0.001). Progression of stenosis was more pronounced in 234 patients (75%) with overstenting of the carotid bifurcation (p=0.004). CONCLUSION: Our results show that significant progression of >/=50% stenosis in the ipsilateral ECA occurs after CAS. There was greater progression of disease in the ipsilateral compared with the contralateral ECA. Progression of disease in the ECA did not lead to the occurrence of occlusion during follow up
de Borst GJ, Hilgevoord AAJ, de Vries JPPM, van der Mee M, Moll FL, van de Pavoordt HDWM, Ackerstaff RGA. Influence of Antiplatelet Therapy on Cerebral Micro-Emboli after Carotid Endarterectomy using Postoperative Transcranial Doppler Monitoring. European Journal of Vascular & Endovascular Surgery 2007; 34(2):135-142.
de Borst GJ, Ackerstaff RG, de Vries JP, Pavoordt ED, Vos JA, Overtoom TT, Moll FL. Carotid angioplasty and stenting for postendarterectomy stenosis: long-term follow-up. Journal of Vascular Surgery 2007; 45(1):118-123.
Abstract: BACKGROUND: Carotid angioplasty and stenting (CAS) for recurrent stenosis after carotid endarterectomy (CEA) has been proposed as an alternative to redo CEA. Although early results are encouraging, the extended durability remains unknown. We present the long-term surveillance results of CAS for post-CEA restenosis. METHODS: Between 1998 and 2004, 57 CAS procedures were performed in 55 patients (36 men) with a mean age of 70 years. The mean interval between CEA and CAS was 83 months (range, 6 to 245). Nine patients (16%) were symptomatic. RESULTS: CAS was performed successfully in all patients. No deaths or strokes occurred. A periprocedural transient ischemic attack (TIA) occurred in two patients. During a mean follow-up of 36 months (range, 12 to 72 months), two patients exhibited ipsilateral cerebral symptoms (1 TIA, 1 minor stroke). In 11 patients (19%), in-stent restenosis (>/=50%) was detected post-CAS at month 3 (n = 3), 12 (n = 3), 24 (n = 2), 36 (n = 1), 48 (n = 1), and 60 (n = 1). The cumulative rates of in-stent restenosis-free survival at 1, 2, 3, and 4 years were 93%, 85%, 82%, and 76%, respectively. Redo procedures were performed in six patients, three each received repeat angioplasty and repeat CEA with stent removal. The cumulative rates of freedom from reintervention at 1, 2, 3, and 4 years were 96%, 94%, 90%, and 84%, respectively. CONCLUSION: Carotid angioplasty and stenting for recurrent stenosis after CEA can be performed with a low incidence of periprocedural complications with durable protection from stroke. The rate of in-stent recurrent stenosis is high, however, and does not only occur early after CAS but is an ongoing process
de Groot AC, Tupker RA. De plaats van tacrolimus en pimecrolimus in de behandeling van constitutioneel eczeem. Bijblijven 2007; 23(2):22-28.
de Heer K, Silbermann MH, Koene HR, Biemond BJ, Muller HP, van Oers MH. Systematische diagnostiek van erytrocytose. Nederlands Tijdschrift voor Geneeskunde 2007; 151(32):1770-1776.
Abstract: Erythrocytosis is a phenomenon with life-threatening complications and a broad differential diagnosis. Erythrocytosis is usually secondary to a cardiopulmonary condition leading to a low arterial oxygen tension. A probable diagnosis can often be made on the basis of the history, physical examination, a measurement of the peripheral oxygen saturation, and simple laboratory tests. The differential diagnosis can be narrowed down by a determination of the erythropoietin concentration and the JAK2 mutation. If the erythrocytosis is found to be non-physiological, then reduction of the haematocrit via bloodletting and, depending on the diagnosis, treatment with acetylsalicylic acid are indicated
de Jong-Pleij EA, Ribbert LS, Tromp E, Bilardo CM. OP09.03: a comparison of 2D and 3D multiplanar ultrasound in the evaluation of the fetal profile. Ultrasound in Obstetrics & Gynecology 2007; 30(4):483.
de Jong B, Herpers BL, Dekker B, Aerts PC, van Dijk H, Rijkers GT, van Velzen-Blad H. Modification of a hemolytic assay for the measurement of functional human mannose-binding lectin by classical pathway inhibition. Nederlands Tijdschrift voor Medische Microbiologie 2007; 15(Suppl):P021.
de Jong P, Braak S, van Heeswijk J, Grutters JC, van Ginneken B, van den Bosch JM, Nossent GD, Prokop M. Development of a CT scoring system for assessing prognosis in pulmonary sarcoidosis. RSNA 2007.
de Jong PC, van Vugt SF. Severe hypocalcemia during treatment with alendronate. 19e Internistendagen : abstractboek :25, 26 & 27 april 2007 MECC Maastricht 2007;63.
de Kroon T, Hoekstra T. Minimaal invasieve mitraalklepchirurgie : hartoperaties via een sleutelgat. Cordiaal 2007; 28(2):44-47.
de Rie MA, van Kuijk AW, Goedkoop AY, Tak PP. Arthritis psoriatica. Nederlands Tijdschrift voor Geneeskunde 2007; 151(31):1716-1722.
Abstract: The symptoms ofpsoriatic arthritis vary from arthralgia and enthesitis to chronic erosive and mutilating arthritis, and are seen in 6-39% of all psoriasis patients. Because of increasing awareness of the clinical signs of psoriatic arthritis among both dermatologists and rheumatologists, the diagnosis ofpsoriatic arthritis is made more often; this is important since earlier diagnosis and treatment can avoid irreversible joint destruction. The overlap between the immunological mechanisms in the pathogenesis ofpsoriasis and psoriatic arthritis has led to the identification of common therapeutic targets, of which tumour-necrosis factor (TNF) is the most important. The successful treatment of psoriasis patients with TNF-a-blocking agents has not only brought about a marked improvement in the quality of life of many patients but has also improved the insight into the pathogenesis, for example by demonstrating that the role of acquired immunity is much more important than was previously thought. The Dutch Society of Dermatology and Venereology and the Dutch Society of Rheumatology have drawn up guidelines for the treatment of patients with psoriasis and psoriatic arthritis using these so-called biologics
de Roos N, Rijkers GT. Probiotica bij Cystic Fibrosis: volop keus, maar wat kies je? CF Nieuws 2007; 38(3):20-25.
de Vijlder HC, ter Borg EJ. A patient with acute renal failure. Netherlands Journal of Medicine 2007; 65(9):360-361.
Abstract: No abstract available
de Vries AC, Besselink MG, Buskens E, Ridwan BU, Schipper M, van Erpecum KJ, Gooszen HG. Randomized controlled trials of antibiotic prophylaxis in severe acute pancreatitis: relationship between methodological quality and outcome. Pancreatology 2007; 7(5-6):531-538.
Abstract: AIM: To evaluate the methodological quality of randomized controlled trials (RCTs) of systemic antibiotic prophylaxis in severe acute pancreatitis in relation to outcome. METHODS: The MEDLINE, EMBASE and Cochrane databases were searched for RCTs that studied the effectiveness of systemic antibiotic prophylaxis in severe acute pancreatitis. A meta-analysis was performed with a random effects model. Methodological quality was quantified by a previously published scoring system (range 0-17 points). RESULTS: Six studies, with a total of 397 participants, obtained a methodological score of at least 5 points and were included. Systemic antibiotic prophylaxis had no significant effect on infection of pancreatic necrosis (absolute risk reduction (ARR) 0.055; 95% CI -0.084 to 0.194) and mortality (ARR 0.058, 95% CI -0.017 to 0.134). Spearman correlation showed an inverse association between methodological quality and ARR for mortality (correlation coefficient -0.841, p = 0.036). CONCLUSIONS: The inverse relationship between methodological quality and impact of antibiotic prophylaxis on mortality emphasizes the importance of high-quality RCTs. At present, adequate evidence for the routine use of antibiotic prophylaxis in severe acute pancreatitis is lacking
de Vries JJ, Vogten JM, de Bruin P, Boerma D, van de Pavoordt HDWM, Hagendoorn J. Mesenterical Lymphangiomatosis Causing Volvulus and Intestinal Obstruction. Lymphatic Research and Biology 2007; 5(4):269-274.
den Ouden H, van Tuyl S, Groenen M, Stolk MF, Kuipers EJ. New endoscopic techniques for obscure gastrointestinal bleeding. Canadian Journal of Gastroenterology 2007; 21(9):597-600.
Abstract: The case of a postmenopausal woman with a congenital aortic stenosis is presented. She presented with severe iron deficiency anemia. After negative extensive gastrointestinal analysis, she was treated with octreotide for six months. After cessation of octreotide, anemia rapidly recurred. A second capsule endoscopy and a double balloon enteroscopy were performed, and an intestinal vascular malformation was found. After surgical segment resection, the patient had stable, normal levels of hemoglobin and no complaints after 14 months of follow-up
Drent M, Grutters JC, Jansen TLThA, van der Heijde D. Sarcoïdose: ontwikkelingen in de medicamenteuze behandeling. Nederlands Tijdschrift voor Allergie 2007; 7(3):82-90.
Duffels MGJ, Vriend JWJ, van der Velde ET, Engelfriet-Rijk CJM, Harms I, Meijboom FJ, Vliegen HW, Veen G, Pieper PG, Mariman ECM, Plokker HWM, van Dijk AJP, Stappers JLM, Tijssen JLM, Tijssen JGP, Mulder BJM, Interuniversitair Cardiologisch Instituut Nederland (ICIN). Vijf jaar CONCOR.Landelijke registratie en DNA-bank van volwassenen met een aangeboren hartafwijking. Hart Bulletin 2007; 38(3):71-73.
Ekkelenkamp MB, van der Bruggen JT, Wolfs TFW, Bonten MJM. A positive culture with Staphylococcus aureus from the tip of an intravascular catheter: to treat or not to treat. Nederlands Tijdschrift voor Medische Microbiologie 2007; 15(Suppl):P057.
Elbers PW. Fast-track microcirculation analysis. Critical Care (London) 2007; 11(6):426.
Elbers PWG, Ince C. The Microcirculation Is a Vulnerable Organ in Sepsis. In: Abraham E, Singer M, editors. Mechanisms of Sepsis-Induced Organ Dysfunction and Recovery. Heidelberg: Springer-Verlag, 2007: 249-262.
Endeman H, Voorn GP, van Velzen-Blad H, Biesma DH. Causative micro-organisms in community acquired pneumonia; high incidence of atypical bacteria and viruses. Nederlands Tijdschrift voor Medische Microbiologie 2007; 15(Suppl):P023.
Erdmann PG, Teunissen LL, van Genderen FR, Notermans NC, Lindeman E, Helders PJ, van Meeteren NL. Functioning of patients with chronic idiopathic axonal polyneuropathy (CIAP). Journal of Neurology 2007; 254(9):1204-1211.
Abstract: Although patients with Chronic Idiopathic Axonal Polyneuropathy (CIAP) report a slow deterioration of sensory and motor functions, the impact of this deterioration on daily functioning has not yet been investigated in detail. The first aim of this crosssectional study involving 56 patients with CIAP was, therefore, to assess patients' functioning with use of the International Classification of Functioning, Disability and Health (ICF). The second aim was to find determinants of walking ability, dexterity, and autonomy. Fatigue and limited walking ability were present in most patients and differed considerably. In regression models, age, muscle strength, and fatigue together explained 63% of the variance in walking ability, which by itself explained almost 50% of the variance in patients' autonomy indoors and outdoors (42% and 49%, respectively). Muscle strength and sensory function scores together explained 30% of the variance in dexterity scores, which in turn explained only 13% of the variance in autonomy indoors. The diminished autonomy of patients with CIAP might be improved by reducing fatigue, by means of training, and by improving walking ability
Ferrari G, de Lazzari C, de Kroon TL, Elstrodt JM, Rakhorst G, Gu YJ. Numerical simulation of hemodynamic changes during beating-heart surgery: analysis of the effects of cardiac position alteration in an animal model. Artificial Organs 2007; 31(1):73-79.
Abstract: Hemodynamic instability, mostly due to vertical lifting of the heart, is usually observed during beating-heart surgical procedures. However, some hemodynamic parameters, such as coronary blood flow, are not routinely measured. A digital computer model of the circulation able to simulate and analyze the effects of heart lifting and the Trendelenburg maneuver, and thus supply detailed hemodynamic information to the clinicians would provide a useful analytical tool. A lumped parameters model of the circulation was applied to both beta-blocked and not beta-blocked pigs. The results confirmed a drop of cardiac output and coronary flow during heart lifting and a rise of both variables after the Trendelenburg maneuver for beta-blocked animals. In not beta-blocked pigs, the analysis was more complex but the model reproduced experimental data and permitted coronary flow to be estimated. These results showed the feasibility of numerical simulation for specific circulatory conditions encountered during beating-heart surgery
Fioole B. Strategies in liver surgery. Utrecht: Utrecht University, 2007.
Fortunati L, van Aalst CW, Prinsen BHCMT, Karthaus V, Lammers J-WJ, Grutters JC, van den Bosch JMM. Proteomics analysis of alveolar macrophages in sarcoidosis patients suggests an increased apoptosis rate and a dysregulation of iron metabolism. Proteomics Europe 2007.
Gerritsen KGF, Slee PHThJ, Bollen ThL, Duurkens VAM. Recurrent pneumonia due to an appendiceal mucinous cystadenocarcinoma. 19e Internistendagen : abstractboek :25, 26 & 27 april 2007 MECC Maastricht 2007;79-80.
Gerritsen WBM. Biomarkers of oxidative stress. Gildeprint Drukkerijen: Enschede, 2007.
Gilligan D, Nicolson M, Smith I, Groen H, Dalesio O, Goldstraw P, Hatton M, Hopwood P, Manegold C, Schramel F, Smit H, van Meerbeeck J, Nankivell M, Parmar M, Pugh C, Stephens R. Preoperative chemotherapy in patients with resectable non-small cell lung cancer: results of the MRC LU22/NVALT 2/EORTC 08012 multicentre randomised trial and update of systematic review. Lancet 2007; 369(9577):1929-1937.
Abstract: BACKGROUND: Although surgery offers the best chance of cure for patients with non-small cell lung cancer (NSCLC), the overall 5-year survival rate is modest, and improvements are urgently needed. In the 1990s, much interest was generated from two small trials that reported striking results with neo-adjuvant chemotherapy, and therefore our intergroup randomised trial was designed to investigate whether, in patients with operable non-small cell lung cancer of any stage, outcomes could be improved by giving platinum-based chemotherapy before surgery. METHODS: Patients were randomised to receive either surgery alone (S), or three cycles of platinum-based chemotherapy followed by surgery (CT-S). Before randomisation, clinicians chose the chemotherapy that would be given from a list of six standard regimens. The primary outcome measure was overall survival, which was analysed on an intention-to-treat basis. This study is registered as an International Standard Randomised Controlled Trial, number ISRCTN25582437. RESULTS: 519 patients were randomised (S: 261, CT-S: 258) from 70 centres in the UK, Netherlands, Germany, and Belgium. Most (61%) were clinical stage I, with 31% stage II, and 7% stage III. Neo-adjuvant chemotherapy was feasible (75% of patients received all three cycles of chemotherapy), resulted in a good response rate (49% [95% CI 43%-55%]) and down-staging in 31% (25%-37%) of patients, and did not alter the type or completeness of the surgery (lobectomy: S: 56%, CT-S: 60%, complete resection: S: 80%, CT-S: 82%). Post-operative complications were not increased in the CT-S group, and no impairment of quality of life was observed. However, there was no evidence of a benefit in terms of overall survival (hazard ratio [HR] 1.02, 95% CI 0.80-1.31, p=0.86). Updating the systematic review by addition of the present result suggests a 12% relative survival benefit with the addition of neoadjuvant chemotherapy (1507 patients, HR 0.88, 95% CI 0.76-1.01, p=0.07), equivalent to an absolute improvement in survival of 5% at 5 years INTERPRETATION: Although there was no evidence of a difference in overall survival with neo-adjuvant chemotherapy, the result is statistically consistent with previous trials, and therefore adds considerable weight to the current evidence
Gittenberger-de Groot AC, Mahtab EA, Hahurij ND, Wisse LJ, Deruiter MC, Wijffels MC, Poelmann RE. Nkx2.5-negative myocardium of the posterior heart field and its correlation with podoplanin expression in cells from the developing cardiac pacemaking and conduction system. Anatomical record 2007; 290(1):115-122.
Abstract: Recent advances in the study of cardiac development have shown the relevance of addition of myocardium to the primary myocardial heart tube. In wild-type mouse embryos (E9.5-15.5), we have studied the myocardium at the venous pole of the heart using immunohistochemistry and 3D reconstructions of expression patterns of MLC-2a, Nkx2.5, and podoplanin, a novel coelomic and myocardial marker. Podoplanin-positive coelomic epithelium was continuous with adjacent podoplanin- and MLC-2a-positive myocardium that formed a conspicuous band along the left cardinal vein extending through the base of the atrial septum to the posterior myocardium of the atrioventricular canal, the atrioventricular nodal region, and the His-Purkinje system. Later on, podoplanin expression was also found in the myocardium surrounding the pulmonary vein. On the right side, podoplanin-positive cells were seen along the right cardinal vein, which during development persisted in the sinoatrial node and part of the venous valves. In the MLC-2a- and podoplanin-positive myocardium, Nkx2.5 expression was absent in the sinoatrial node and the wall of the cardinal veins. There was a mosaic positivity in the wall of the common pulmonary vein and the atrioventricular conduction system as opposed to the overall Nkx2.5 expression seen in the chamber myocardium. We conclude that we have found podoplanin as a marker that links a novel Nkx2.5-negative sinus venosus myocardial area, which we refer to as the posterior heart field, with the cardiac conduction system
Go PMNYH, Vahl AC, de Nie AJ. Indicatoren. Nederlands Tijdschrift voor Heelkunde 2007; 16(5):477-479.
Goud AL, de Vries JP. Diagnose in beeld (317). Een man met halsletsel na een ongeval. Nederlands Tijdschrift voor Geneeskunde 2007; 151(13):757-758.
Abstract: A 20-year-old man suffered a larynx rupture and mucosal laceration, and had local subcutaneous emphysema, due to a motor vehicle accident
Greve JWM, Janssen IMC, van Ramshorst B. Maagverkleining bij volwassenen met morbide obesitas in Nederland. Nederlands Tijdschrift voor Geneeskunde 2007; 151(20):1116-1120.
Grootenboers MJ, Hendriks JM, van Boven WJ, Knibbe CA, van Putte B, Stockman B, de Bruijn E, Vermorken JB, van Schil PE, Schramel FM. Pharmacokinetics of isolated lung perfusion with melphalan for resectable pulmonary metastases, a phase I and extension trial. Journal of Surgical Oncology 2007; 96(7):583-589.
Abstract: BACKGROUND: Isolated lung perfusion (ILuP) with melphalan was performed under normo- and hyperthermic conditions combined with pulmonary metastasectomy for patients with resectable lung metastases. We present the results of pharmacokinetic analysis of a phase I and extension trial. METHODS: Twenty-one procedures of ILuP with melphalan were performed in the phase I trial according to a dose-escalation schedule under normothermic and hyperthermic conditions followed by surgical resection of pulmonary metastases. In an extension trial 8 additional procedures with 15 and 45 mg melphalan were performed under hyperthermic conditions. Samples of serum, perfusate, lung, and tumor tissue were obtained. RESULTS: High perfusate concentrations of melphalan were recorded in contrast to low systemic concentrations. Marked interindividual variability was observed in melphalan concentrations in perfusate, tumor, and lung tissue. Statistically significant correlation between melphalan dose, and perfusate area under the concentration-time curve (R(2) = 0.578, P = 0.001) and lung tissue concentrations (R(2) = 0.459, P = 0.028) were noted. No significant correlation between melphalan dose and tumor tissue concentrations could be established. CONCLUSION: Isolated lung perfusion effectively delivers high doses of melphalan to the lung and tumor tissues with minimal systemic levels. Significant correlation between perfused melphalan dose, perfusate area under the concentration-time curve and lung tissue melphalan concentrations were observed. J. Surg. Oncol. 2007;96:583-589. (c) 2007 Wiley-Liss, Inc
Grootenboers MJ, Schramel FM, Hendriks JM, van Boven WJ, van Schil PE, van Putte BP. Selective pulmonary artery perfusion: a novel method for the treatment of pulmonary malignancies. Acta Chirurgica Belgica 2007; 107(4):361-367.
Abstract: Selective pulmonary artery perfusion (SPAP) is a modality of regional chemotherapy first investigated in the 1950's. A number of studies in animal models documented pharmacokinetic superiority with high-dose local cytostatic drug concentrations when compared to intravenous administration. Blood flow occlusion of the pulmonary artery before or after drug injection results in further increase in local drug concentrations. Animal tumor models with sarcoma and coloncarcinoma confirm anti-tumour efficacy in cytostatic SPAP. In human investigations, feasibility and safety of chemotherapeutic SPAP in humans has been documented. Recent encouraging investigations of SPAP with gemcitabine and blood flow occlusion in a porcine model emphasize the need for further investigations in humans with pulmonary malignancies for safety and efficacy assessments
Grootenboers MJ, Schramel FM, van Boven WJ, van Putte BP, Hendriks JM, van Schil PE. Re-evaluation of toxicity and long-term follow-up of isolated lung perfusion with melphalan in patients with resectable pulmonary metastases: a phase I and extension trial. Annals of Thoracic Surgery 2007; 83(3):1235-1236.
Haas FJLM, Kamphuisen PW. The Role of D-Dimer in the Diagnosis of Deep Venous Thrombosis and Pulmonary Embolism. Imaging Decisions MRI 2007; 11(3):23-28.
Haas FJLM, Schutgens REG, Kluft C, Biesma DH. The use of the endogenous thrombin potential assay in the diagnosis of deep venous thrombosis. Journal of Thrombosis & Haemostasis 2007; 5(Suppl 2):P-S-395.
Haas FJLM, Schutgens REG, Biesma DH. The clinical validation of a new quantitative high sensitive d-dimer assay. Journal of Thrombosis & Haemostasis 2007; 5(Suppl 2):P-S-394.
Haas FJLM, Hackeng CM, Schutgens REG, Biesma DH. Evaluation of two soluble fibrin monomer assays. Journal of Thrombosis & Haemostasis 2007; 5(Suppl 2):P-S-393.
Hadithi M, Al-Toma A, Oudejans J, van Bodegraven AA, Mulder CJ, Jacobs M. The value of double-balloon enteroscopy in patients with refractory celiac disease. American Journal of Gastroenterology 2007; 102(5):987-996.
Abstract: OBJECTIVE: Patients with refractory celiac disease can develop enteropathy-associated T-cell lymphoma (EATL) or ulcerative jejunitis. Double-balloon enteroscopy allows examination of the small bowel. We prospectively assessed the value of this technique in patients with refractory celiac disease in a tertiary referral center. METHODS: Small bowel enteroscopy was performed in a total of 21 consecutive patients for lesions like ulcerations (high risk). Biopsy specimens were taken from such lesions and from examined small bowel at three different levels of scope insertion depth. Tissue specimens were evaluated for the modified Marsh classification and for the presence of EATL. RESULTS: Twenty-four procedures were successfully performed without complications. EATL was found in five patients (24%, 95% CI 10-45%) as circumferential, discrete, or confluent ulcerations. In three of them, Marsh III was found while in the other two patients with EATL Marsh I was found. Another two patients (9%, 95% CI 2-28%) had ulcerative jejunitis in the absence of EATL and histology was compatible with Marsh III. In the remaining 14 patients (54%, 95% CI 35-73%), no high-risk lesions were found. Double-balloon enteroscopy could exclude the presence of EATL in four patients that was suggested by abdominal computerized tomography. CONCLUSIONS: Complications of refractory celiac disease like ulcerative jejunitis or EATL could efficiently be detected or excluded by double-balloon enteroscopy. This technique should be reserved for patients with refractory celiac disease or patients with a past history of EATL
Hadithi M, Akol H, Al-Toma A, Jacobs M, Mulder CJ. Indigo carmine chromoendoscopic appearances of enteropathy-associated T-cell lymphoma during double-balloon endoscopy in a patient with celiac disease. Endoscopy 2007; 39(Suppl 1):E212-E213.
Hakmat H, Al-Toma A, Mallant MPJH, Mulder CJJ, Jacobs MAJM . Histoacryl obliteration of jejunal varices. Case no 24. In: Mulder CJJ, editor. Atlas of double-balloon endoscopy. 2007: 57.
Harkisoen S, Slee PHThJ. Plain abdominal radiography in internal medicine on the emergency department : is it meaningful? 19e Internistendagen : abstractboek :25, 26 & 27 april 2007 MECC Maastricht 2007;11-12.
Harmsze AM, Deneer VHM, Wiltink EH. Langdurig verminderd effect van cumarinederivaten na gebruik van rifampicine. Nederlands Tijdschrift voor Geneeskunde 2007; 151(35):1945-1949.
Hartman J, Kelder H, Ackerstaff R, van Swieten H, Vermeulen F, Bogers A. Preserved hyperaemic response in (distal) string sign left internal mammary artery grafts. European Journal of Cardio-Thoracic Surgery 2007; 31(2):283-289.
Abstract: Objective: To correlate supraclavicular ultrasonography at rest and in hyperaemic response with angiographically patent and (distal) 'string sign' left internal mammary artery (LIMA) to left anterior descending (LAD) area grafts. Methods: Fifty-three patients with LIMA to LAD area grafting were prospectively entered in a follow-up study. Arteriography (native and LIMA) was performed at 1.4+/-0.8 years postoperatively and ultrasonography was performed at rest, in hyperaemic response and 2min after hyperaemic response at 1.8+/-0.8 years postoperatively and was compared to arteriography. Ultrasonographic parameters analysed were systolic and diastolic peak velocity, systolic and diastolic velocity integral, diastolic/systolic peak velocity ratio and diastolic/total velocity integral ratio. Results: One patient was excluded because obesity hampered ultrasonography. Arteriography demonstrated functional grafts in 43 patients (group I), sequential distal 'string sign grafts' in 4 patients (group II) and total 'string sign grafts' in 5 patients (group III). Between the groups all ultrasonographic velocities showed a significant linear relation (p</=0.013) at rest and during maximal hyperaemic response all velocities increased significantly within all groups (p</=0.018). A significant decrease was found 2min after hyperaemic response and diastolic velocities showed a significant linear relation (p</=0.032). Conclusions: String sign LIMA grafts' were found in 9/52 (17.3%) patients. All patent and all 'string sign grafts' showed a shift towards a coronary flow profile in the proximal segment postoperatively. The study revealed the 'functionality' of the patent and the (distal) 'string sign LIMA graft' in regard to myocardial oxygen demand. 'String sign grafts' are 'recruitable' on demand
Hartman JM, Kelder HC, Ackerstaff RG, Swieten HA, Vermeulen FE, Bogers AJ. Preserved hyperaemic response in supraclavicular ultrasonography demonstrates function on demand of the LIMA to LAD string sign graft after CABG. Journal of Cardiovascular Surgery 2007; 48(1):59-66.
Abstract: AIM: To correlate supraclavicular ultrasonography with angiographically patent and string sign left internal mammary artery (LIMA) to left anterior descending artery (LAD) grafts. METHODS: Sixteen patients with a single LIMA anastomosis to the LAD were prospectively entered in a follow-up study. The supraclavicular ultrasonography of the LIMA origin was studied preoperatively and at 5.3+/-3.6 months and 1.7+/-0.4 year postoperatively. At the late postoperative ultrasonography electrocardiographically controlled hyperemic response was also studied for 6 min. Control angiography was performed at 1.5+/-0.8 year. Differences within groups were tested with a paired t-test and between groups with an unpaired t-test. RESULTS: Control angiography showed in 13 patients (group I) a patent LIMA graft and in 3 patients (group II) a string sign LIMA graft. Preoperative blood velocities were not significantly different between groups. Postoperatively, both groups revealed higher diastolic and lower systolic blood velocities compared to preoperative values. The blood velocities at rest did not change in group I and all velocities decreased in group II in time postoperatively. The blood velocities in maximal hyperemic response increased significantly within the groups and were not significantly different between the groups. No ischemia could be detected electrocardiographically during hyperemic response and no patient presented angina. CONCLUSIONS: Both groups showed a shift towards coronary type diastolic blood velocities at rest and at hyperaemic response. Significant hyperemic response was also present in string sign LIMA grafts and demonstrates response capacity to increased myocardial oxygen demand
Hartman JM, Kelder HC, Ackerstaff RGA, van Swieten HA, Vermeulen FEE, Bogers JJC. Can Late Supraclavicular Echo Doppler Reliably Predict Angiographical String Sign of Lima to Lad Area Grafts? Echocardiography 2007; 27(7):689-696.
Hartman JM, Kelder HC, Ackerstaff RGA, van Swieten HA, Vermeulen FEE, Bogers AJJC. Preserved hyperaemic response in (distal) string sign lima grafts. Interactive Cardiovascular and Thoracic Surgery 2007; 5(suppl 2):S217-S218.
Heidema AG, Feskens EJ, Doevendans PA, Ruven HJ, van Houwelingen HC, Mariman EC, Boer JM. Analysis of multiple SNPs in genetic association studies: comparison of three multi-locus methods to prioritize and select SNPs. Genetic epidemiology 2007; 31(8):910-921.
Abstract: Nonparametric approaches have been developed that are able to analyze large numbers of single nucleotide polymorphisms (SNPs) in modest sample sizes. These approaches have different selection features and may not provide similar results when applied to the same dataset. Therefore, we compared the results of three approaches (set association, random forests and multifactor dimensionality reduction [MDR]) to select from a total of 93 candidate SNPs a subset of SNPs that are important in determining high-density lipoprotein (HDL)-cholesterol levels. The study population consisted of a random sample from a Dutch monitoring project for cardiovascular disease risk factors and was dichotomized into cases (low HDL-cholesterol, n = 533) and non-cases (high HDL-cholesterol, n = 545) based on gender-specific median values for HDL cholesterol. Clearly, all three approaches prioritized three SNPs as important (CETP Taq1B, CETP-629 C/A and LPL Ser447X). Two SNPs with weaker main effects were additionally prioritized by random forests (APOC3 3175 G/C and CCR2 Val62Ile), whereas MTHFR 677 C/T was selected in combination with CETP Taq1B as best model by MDR. Obtained p-values for the selected models were significant for the set association approach (p =.0019), random forests (p<.01) and MDR (p<.02). In conclusion, the application of a combination of multi-locus methods is a useful approach in genetic association studies to select a well-defined set of important SNPs for further statistical and epidemiological interpretation, providing increased confidence and more information compared with the application of only one method. Genet. Epidemiol. 2007. (c) 2007 Wiley-Liss, Inc
Hekmat H, Al-Toma A, Mallant MP, Mulder CJ, Jacobs MA. Endoscopic N-butyl-2-cyanoacrylate (Histoacryl) obliteration of jejunal varices by using the double balloon enteroscope. Gastrointestinal Endoscopy 2007; 65(2):350-352.
Hellings WE, Moll FL, de Vries JP, de Kleijn D, Pasterkamp G. Abstract 2994: Atherosclerotic Plaque Histology Predicts Restenosis after Carotid Endarterectomy: a Prospective Cohort Study in 500 Patients. Circulation 2007; 116(16 suppl):II-669-II-670.
Hellings WE, Pasterkamp G, Verhoeven BA, de Kleijn DP, de Vries JP, Seldenrijk CA, van den Broek T, Moll FL. Gender-associated differences in plaque phenotype of patients undergoing carotid endarterectomy. Journal of Vascular Surgery 2007; 45(2):289-296.
Abstract: BACKGROUND: Carotid endarterectomy to prevent a stroke is less beneficial for women compared with men. This benefit is lower in asymptomatic women compared with asymptomatic men or symptomatic patients. A possible explanation for this gender-associated difference in outcome could be found in the atherosclerotic carotid plaque phenotype. We hypothesize that women, especially asymptomatic women, have more stable plaques than men, resulting in a decreased benefit of surgical plaque removal. METHODS: Carotid endarterectomy specimens of 450 consecutive patients (135 women, 315 men) were studied. The culprit lesions were semi-quantitatively analyzed for the presence of macrophages, smooth muscle cells, collagen, calcifications, and luminal thrombus. Plaques were categorized in three phenotypes according to overall presentation and the amount of fat. Protein was isolated from the plaques for determination of interleukin-6 (IL-6) and IL-8 concentrations and matrix metalloproteinase-8 (MMP-8) and MMP-9 activities. RESULTS: Atheromatous plaques (>40% fat) were less frequently observed in women than in men (22% vs 40%; P < .001). In addition, plaques obtained from women more frequently revealed low macrophage staining (11% vs 18%; P = .05) and strong smooth muscle cell staining (38% vs 24%; P = .001). Compared with men, women had a lower plaque concentration of IL-8 (P = .001) and lower MMP-8 activity (P = .01). The observed differences were most pronounced in asymptomatic women, who showed the most stable plaques, with an atheromatous plaque in only 9% of cases compared with 39% in asymptomatic men (P = .02). In addition, a large proportion of plaques obtained from asymptomatic women showed high smooth muscle cell content (53% vs 30%; P = .03) and high collagen content (55% vs 24%; P = .003). All relations between gender and plaque characteristics, except for MMP-8, remained intact in a multivariate analysis, including clinical presentation and other cardiovascular risk factors. CONCLUSION: Carotid artery plaques obtained from women have a more stable, less inflammatory phenotype compared with men, independent of clinical presentation and cardiovascular risk profile. Asymptomatic women demonstrate the highest prevalence of stable plaques. These findings could explain why women benefit less from carotid endarterectomy compared with men
Hellings WE, Pasterkamp G, Vollebregt A, Seldenrijk CA, de Vries JP, Velema E, de Kleijn DP, Moll FL. Intraobserver and interobserver variability and spatial differences in histologic examination of carotid endarterectomy specimens. Journal of Vascular Surgery 2007; 46(6):1147-1154.
Abstract: INTRODUCTION: Studies using histologic examination and protein analysis of atherosclerotic plaques are increasingly being performed, but reproducibility of plaque histology and variation of plaque composition among different parts of the plaque, which are key to reliability of these studies, are relatively unexplored. Therefore, this study investigated the intraobserver and interobserver variability of plaque histology and spatial variability in plaque composition. METHODS: Atherosclerotic plaques (n = 100) obtained during carotid endarterectomy were divided into 0.5-cm segments. Paraffin sections were stained and semiquantitatively analyzed (four categories: no, minor, moderate, and heavy) for fat, macrophages, smooth muscle cells, collagen, calcification, thrombus, and overall phenotype. First, to determine the intraobserver and interobserver reproducibility, two independent observers independently analyzed the plaques. Second, to investigate spatial variability in plaque composition, histologic appearances of the culprit lesions (0-segment) were compared with the histologic appearances of adjacent (+5 mm) and more distant (+10 mm) plaque segments of 30 specimens. RESULTS: The kappa values for intraobserver variability of fat, macrophages, smooth muscle cells, collagen, calcifications, thrombus, and overall phenotype were 0.83, 0.85, 0.71, 0.63, 0.81, 0.80, and 0.86, respectively, and kappa values for interobserver variability were 0.68, 0.74, 0.54, 0.59, 0.82, 0.75, and 0.71, respectively. Comparison of the histologic scorings of adjacent segments revealed a mean kappa of 0.40 (range, 0.33 to 0.60). When the culprit segment was compared with the more distant segment, the mean kappa was 0.24; however, in 91% of cases, the difference between the culprit segment and the distal segment was one category or less. CONCLUSION: Semiquantitative analysis of carotid atherosclerotic plaque histology was well reproducible, both intraobserver and interobserver. Although variation between different plaque segments in histologic appearance was observed, differences were small in almost all cases. Variability in histologic examination needs to be taken into account in studies comparing plaque imaging with histopathology and plaque research studies
Hemmink GJM, Aanen MC, Bredenoord AJ, Weusten BLAM, Smout AJPM. Automatic analysis of 24-h oesophageal impedance signals for detection of gastro-oesophageal reflux: how far are we? Gut 2007; 56(Suppl III):A209.
Hennis PJ, Leusink JA. Anesthesiologie. 2e herziene dr ed. Houten: Bohn Stafleu Van Loghum, 2007.
Hermans H, Post MC, Thijs V, Spaepen M, Budts WI. Increased prevalence of migraine in adult congenital heart disease. Heart 2007; 93(3):361-362.
Heron M, Claessen AME, Grutters JC. Invariant Natural Killer T Cells in Obstructive Pulmonary Diseases. New England Journal of Medicine 2007; 357(2):194.
Heron M, Grutters JC, Claessen AME, van Velzen-Blad H, van den Bosch JMM. Monitoring disease activity in pulmonary sarcoidosis: measuring expression of proinflammatory surface molecules CD16, CD69 and VLA-1 on peripheral blood monocytes. American Journal of Respiratory & Critical Care Medicine 2007; 175:A186.
Herpers BL, IJzerman EPF, de Jong BAW, Bruin JP, Kuipers S, Lettinga KD, van Hannen EJ, Rijkers GT, van Velzen-Blad H, de Jongh BM. Low functional levels of mannose-binding lectin despite normal genotypes in Legionella pneumophila pneumonia. Nederlands Tijdschrift voor Medische Microbiologie 2007; 15(Suppl):P004.
Herpers BL, Endeman H, de Jong BAW, van Hannen EJ, Rijkers GT, van Velzen-Blad H, Biesma DH, Grutters JC, Voorn GP, de Jongh BM. Pathogen related association of mannose-binding lectin deficiency with community acquired pneumonia. Nederlands Tijdschrift voor Medische Microbiologie 2007; 15(Suppl):P005.
Hettinga YM, Verdonck LF, Fijnheer R, Rijkers GT, Rothova A. Anterior uveitis: a manifestation of graft-versus-host disease. Ophthalmology 2007; 114(4):794-797.
Abstract: PURPOSE: To describe the occurrence of anterior uveitis along with systemic manifestations of chronic graft-versus-host disease (GVHD) after nonmyeloablative allogeneic hematopoietic stem cell transplantation (HSCT) in 3 patients with hematologic malignancies. DESIGN: Retrospective small case series. PARTICIPANTS: Three patients who underwent HSCT and 4 age- and gender-matched controls for cytokine analysis in ocular fluid. METHODS: Interventional study of patients who underwent HSCT. Screening for evidence of infectious causes and immunological analysis of ocular fluid samples. MAIN OUTCOME MEASURES: Clinical features of uveitis and results of aqueous analysis. RESULTS: Anterior uveitis developed during an exacerbation of chronic GVHD in 3 patients after allogeneic HSCT for hematologic malignancies. Patients exhibited no abnormalities on extensive uveitis screening, and in addition, serologic and wide-ranging aqueous analysis showed no evidence of recent infections. We observed signs of inflammation in the ocular fluid in 2 of 3 patients by the determination of different cytokines. No other explanation for uveitis was found except the exacerbation of GVHD. Treatment, both systemic and topical, directed to chronic GVHD induced remission of uveitis in all patients along with amelioration of other signs of GVHD. CONCLUSIONS: Anterior uveitis occurred in the wake of the acute exacerbation of chronic GVHD after HSCT and may represent an ocular manifestation of chronic GVHD
Hietbrink F, Besselink MG, Renooij W, Leenen LP. Pitfalls in gastrointestinal permeability measurement in ICU patients. Intensive Care Medicine 2007; 33(12):2216.
Hoekstra T. Een "Walk Through" door de opnamedag. TvZ: Tijdschrift voor Verpleegkundigen 2007; 117(9):45-47.
Hoogenboom LJ. Anesthesie bij thoraxchirurgie. In: Hennis PJ, Leusink JA, editors. Anesthesiologie. Houten: Bohn Stafleu Van Loghum, 2007: 439-448.
Jaarsma W, Sutherland G, Cramer MJ. Computerized Closed Loop Delivery of Arbutamine, a New Agent for the Diagnosis of Coronary Artery Disease. Circulation 2007; 86(I):126.
Jahangier Z, van der Zant FM, Jacobs J, Riedstra H, Gommans G, Verzijlbergen J, Bijlsma J, van Isselt J. The intra-articular distribution of 90Yttrium does not influence the clinical outcome of radiation synovectomy of the knee. Annals of the Rheumatic Diseases 2007; 66(8):1110-1112.
Abstract: OBJECTIVES: To assess the impact of the intra- articular distribution of (90)Yttrium-citrate ((90)Y) on the clinical effect of radiosynoviorthesis (RSO) of the knee and on (90)Y leakage from this joint. METHODS: Patients with arthritis of the knee received 185 MBq (90)Y combined with a glucocorticoid, followed by clinical bed rest. Intra- articular (90)Y distribution, measured with a dual head gamma camera immediately or after 24 hours, was scored as mainly diffuse or mainly focal. Leakage to regional lymph nodes, the liver and spleen was assessed with a dual head gamma camera after 24 hours. Clinical effect was scored after 6 months by a composite change index (CCI), range 0-12; responders were defined as having a CCI >/= 6. RESULTS: Seventy-eight knees of 69 patients, mostly suffering from undifferentiated arthritis (42%) or RA (28%), were treated. (90)Y distribution was mainly diffuse in 54% and mainly focal in 46% with clinical response rates of 40% vs. 56%, respectively, P=0.3. CCI was not correlated with distribution. (90)Y leakage was found only to the liver and the spleen (mean leakage 0.4% and 1.1%, respectively). Leakage was significantly less in case of diffuse intra- articular (90)Y distribution, whereas leakage to the liver was correlated with distribution (r=0.68, P<0.001). (90)Y leakage was not correlated with CCI. CONCLUSIONS: Intra-articular (90)Y distribution does not influence the clinical effect of RSO of the knee. Although (90)Y leakage from the joint is less if (90)Y distributes diffusely in the joint cavity, leakage does not seem to hamper the clinical effect
Jansen A, van Ramshorst B. Laparoscopische colonresectie. Eerste klinische ervaringen. Nederlands Tijdschrift voor Heelkunde 2007; 1(3):510.
Jansen WPJ, de Ruiter GS, Dirkali A, Wever EFD. Deteriorating consciousness and pathognomic ECG: risk of sudden death? Netherlands Heart Journal 2007; 15(9):313, 323.
Janssen R, Grutters JC. Wat is 'alveolar damage' en welke oorzaken zijn hier van bekend? Longartsen Vademecum 2007; 10(10).
Jonker G, van Swol CF, Brandsma D, Boezeman EH, van Dongen HPA, Nijhuis HJA. 452 Inhibition of cortical laser evoked potentials by transcutaneous electrical nerve stimulation. European Journal of Pain 2007; 11(S1):S200.
Kaandorp CJE, van der Waal RIF. Klinische probleemstellingen : onderzoek en diagnostiek van 236 aandoeningen. Houten: Prelum uitgevers, 2007.
Karakus A, Banga N, Voorn GP, Meinders AJ. Dengue shock syndrome and rhabdomyolysis. Netherlands Journal of Medicine 2007; 65(2):78-81.
Kardux JJ, van Es HW, Rensing BJ. Case 119: Double-chambered Right Ventricle. Radiology 2007; 244(2):617-619.
Kardux JJ, van Es HW, Rensing BJ. Case 119. Radiology 2007; 243(1):286-287.
Karthaus VLJ, Donkers HHLM, van den Herik HJ, Grutters JC, van den Bosch JMM. Clustering of BAL variables in sarcoidosis patients using dimensionality reduction techniques. American Journal of Respiratory & Critical Care Medicine 2007; 175:A363.
Kastrati A, Mehilli J, Pache J, Kaiser C, Valgimigli M, Kelbaek H, Menichelli M, Sabate M, Suttorp MJ, Baumgart D, Seyfarth M, Pfisterer ME, Schomig A. Analysis of 14 Trials Comparing Sirolimus-Eluting Stents with Bare-Metal Stents. New England Journal of Medicine 2007; 356(10):1030-1039.
Abstract: Background The long-term effects of treatment with sirolimus-eluting stents, as compared with bare-metal stents, have not been established. Methods We performed an analysis of individual data on 4958 patients enrolled in 14 randomized trials comparing sirolimus-eluting stents with bare-metal stents (mean follow-up interval, 12.1 to 58.9 months). The primary end point was death from any cause. Other outcomes were stent thrombosis, the composite end point of death or myocardial infarction, and the composite of death, myocardial infarction, or reintervention. Results The overall risk of death (hazard ratio, 1.03; 95% confidence interval [CI], 0.80 to 1.30) and the combined risk of death or myocardial infarction (hazard ratio, 0.97; 95% CI, 0.81 to 1.16) were not significantly different for patients receiving sirolimus-eluting stents versus bare-metal stents. There was a significant reduction in the combined risk of death, myocardial infarction, or reintervention (hazard ratio, 0.43; 95% CI, 0.34 to 0.54) associated with the use of sirolimus-eluting stents. There was no significant difference in the overall risk of stent thrombosis with sirolimus-eluting stents versus bare-metal stents (hazard ratio, 1.09; 95% CI, 0.64 to 1.86). However, there was evidence of a slight increase in the risk of stent thrombosis associated with sirolimus-eluting stents after the first year. Conclusions The use of sirolimus-eluting stents does not have a significant effect on overall long-term survival and survival free of myocardial infarction, as compared with bare-metal stents. There is a sustained reduction in the need for reintervention after the use of sirolimus-eluting stents. The risk of stent thrombosis is at least as great as that seen with bare-metal stents. Notice: This article was published at www.nejm.org on February 12, 2007. It will appear in the March 8 issue of the Journal. Click on "PDF" for the full text. Copyright 2007 Massachusetts Medical Society
Kastrati A, Dibra A, Spaulding C, Laarman GJ, Menichelli M, Valgimigli M, Di Lorenzo E, Kaiser C, Tierala I, Mehilli J, Seyfarth M, Varenne O, Dirksen MT, Percoco G, Varricchio A, Pittl U, Syvanne M, Suttorp MJ, Violini R, Schomig A. Meta-analysis of randomized trials on drug-eluting stents vs. bare-metal stents in patients with acute myocardial infarction. European Heart Journal 2007; 28(22):2706-2713.
Abstract: Aims To compare the efficacy and safety of drug-eluting stents vs. bare-metal stents in patients with acute ST-segment elevation myocardial infarction. Methods and results We performed a meta-analysis of eight randomized trials comparing drug-eluting stents (sirolimus-eluting or paclitaxel-eluting stents) with bare-metal stents in 2786 patients with acute ST-segment elevation myocardial infarction. All patients were followed up for a mean of 12.0-24.2 months. Individual data were available for seven trials with 2476 patients. The primary efficacy endpoint was the need for reintervention (target lesion revascularization). The primary safety endpoint was stent thrombosis. Other outcomes of interest were death and recurrent myocardial infarction. Drug-eluting stents significantly reduced the risk of reintervention, hazard ratio of 0.38 (95% CI, 0.29-0.50), P < 0.001. The overall risk of stent thrombosis: hazard ratio of 0.80 (95% CI, 0.46-1.39), P = 0.43; death: hazard ratio of 0.76 (95% CI, 0.53-1.10), P = 0.14; and recurrent myocardial infarction: hazard ratio of 0.72 (95% CI, 0.48-1.08, P = 0.11) was not significantly different for patients receiving drug-eluting stents vs. bare-metal stents. Conclusion The use of drug-eluting stents in patients with acute ST-segment elevation myocardial infarction is safe and improves clinical outcomes by reducing the risk of reintervention compared with bare-metal stents
Kaya A, Heijmen RH, Vreuls W, Seldenrijk CA, Schepens MA. Chronic Type A Dissection in a Pulmonary Autograft. Journal of Heart Valve Disease 2007; 16(2):162-164.
Abstract: A 37-year-old patient presented with severe aortic valve insufficiency due to massive dilatation of the neo-aortic root (77 mm diameter) 14 years after a Ross procedure. Intraoperatively, the dilatation appeared to be caused by a localized chronic dissection of the pulmonary autograft. Surgery consisted of a modified Bentall procedure with a mechanical composite valve, with an uncomplicated postoperative course
Keijsers R, Grutters JC, Tiel-van Buul M, Lavalaye J, du Bois RM, Thomeer MJ, van den Bosch JM, Verzijlbergen JF. Molecular imaging of sarcoidosis and its use in clinical practice. American Journal of Respiratory & Critical Care Medicine 2007; 175:A362.
Keijsers RGM, van Diepen VM, van den Bosch JMM, Verzijlbergen FJ, Grutters JC. Infliximab treatment in sarcoidosis patients: monitoring with F-18 DG PET and predicting disease recurrence. European Journal of Nuclear Medicine & Molecular Imaging 2007; 34(Suppl 2):S239.
Keijsers RGM, Verzijlbergen JF, Tiel-van Buul MMC, Lavalaye J, van den Bosch JMM, Grutters JC. Correlation of clinical response and 18F-FDG PET in sarcoidosis patients treated with infliximab. Poster Joint Molecular Imaging congres, 8-11 september, Providence, USA 2007.
Keijsers RGM, van Diepen VM, van den Bosch JMM, Verzijlbergen JF, Grutters JC. Correlation of clinical response to infliximab with metabolic activity on F-18 DG PET scan in sarcoidosis. AMI 2007.
Keijsers RGM, van Diepen DM, van den Bosch JMM, Verzijlbergen JF, Grutters JC. Infliximab treatment in sarcoidosis: F-18 DG PET monitoring and predicting disease recurrence. EANM Congress Copenhagen 2007.
Keijsers RGM, Grutters JC, Tiel-van Buul MMC, Lavalaye J, van den Bosch JMM, Verzijlbergen JF. Molecular imaging of sarcoidosis and its use in clinical practice. Poster ATS congres, 18-25 mei, San Francisco, USA 2007.
Kleiboer AM, Kuijer RG, Hox JJ, Jongen PJ, Frequin ST, Bensing JM. Daily negative interactions and mood among patients and partners dealing with multiple sclerosis (MS): The moderating effects of emotional support. Social Science & Medicine 2007; 64(2):389-400.
Abstract: Negative interactions with intimate partners may have adverse consequences for well-being, especially for individuals dealing with chronic illness. However, it is not clear whether negative interactions affect both dimensions of positive and negative well-being and factors that may moderate this effect have not been well-described. The aim of the present study was to examine the association between daily received negative responses from the partner and end-of-day positive and negative mood in patients with multiple sclerosis (MS) and their intimate partners. Further, the moderating role of receiving emotional support from the partner on the same day was examined. Sixty-one MS patients and their intimate partners were approached via one MS centre and the neurology department of one hospital in the Netherlands and completed computerized diaries for 14 days. Both partners filled out diaries at the end of each day, recording received negative responses, emotional support and end-of-day positive and negative mood. In line with a domain specific model, patients or partners who reported receiving negative responses on a day had higher end-of-day negative mood, whereas received negative responses were unrelated to end-of-day positive mood. Further, for both patients and partners, the adverse effect of received negative responses on end-of day mood was moderated by receiving emotional support on the same day
Koene HR, Biemond BJ, van der Schoot CE. Van gen naar ziekte; JAK2 en polycythaemia vera. Nederlands Tijdschrift voor Geneeskunde 2007; 151(32):1784-1787.
Abstract: The identification of a point mutation in the JAK2 gene in most patients with polycythaemia vera (PV) has led to increased insight into the pathogenesis of the disease. The mutation causes cytokine-independent growth and proliferation of haematopoietic precursor cells, leading to erythrocytosis. The JAK2-V617F mutation is present in 65-97% of PV-patients and, when found, is indicative for the disease. Future research will have to show if the mutated gene can serve as a target for specific, antiproliferative therapy
Koene HR. Nieuwe behandelmethoden voor auto-immuuntrombocytopenie. Nederlands Tijdschrift voor Geneeskunde 2007; 151(47):2609-2614.
Abstract: --For many years, splenectomy has been considered the only therapy with proven efficacy in patients with relapsed/refractory idiopathic thrombocytopenic purpura (ITP) following corticosteroid therapy. --A broad spectrum of (mostly immunosuppressive) agents are available for patients who fail to respond to splenectomy. However, the risks associated with these agents sometimes outweigh their benefits. --Recently, several new or renewed strategies have been evaluated for chronic refractory ITP. --Short-term therapy with high-dose dexamethasone is an effective alternative to long-term treatment with corticosteroids. --Depletion of B lymphocytes with rituximab, an agent that has an established role in the treatment of non-Hodgkin's lymphoma, also appears to be effective in autoimmune disorders, particularly in ITP. --Although the main problem in ITP is the increased destruction of thrombocytes, stimulation of thrombocyte production with thrombopoietin(TPO)-receptor agonists can increase thrombocyte counts. --Two TPO-receptor agonists, AMG531 and eltrombopag, induce responses in 70-80% of ITP patients and are expected to gain approval for use in ITP soon
Kolditz DP, Wijffels MC, Blom NA, van der Laarse A, Markwald RR, Schalij MJ, Gittenberger-de Groot AC. Persistence of functional atrioventricular accessory pathways in postseptated embryonic avian hearts: implications for morphogenesis and functional maturation of the cardiac conduction system. Circulation 2007; 115(1):17-26.
Abstract: BACKGROUND: During heart development, the ventricular activation sequence changes from a base-to-apex to an apex-to-base pattern. We investigated the possibility of impulse propagation through remnants of atrioventricular (AV) connections in quail hearts. METHODS AND RESULTS: In 86 hearts (group A, HH30-34, n=15; group B, HH35-44, n=65; group C, 5 to 6 months, n=6) electrodes were positioned at the left atrium, right ventricular base, left ventricular (LV) base, and LV apex. In group A, LV base activation preceded LV apex activation in the majority of cases (60%; 9 of 15), whereas hearts in group B primarily demonstrated an LV apex-to-base activation pattern (72%; 47 of 65). Interestingly, in group B, the right ventricular base (17%; 11 of 65) or LV base (8%; 5 of 65) exhibited premature activation in 25% (16 of 65) of cases, whereas in 26% (17 of 65), the right ventricular base or LV base was activated simultaneously with the LV apex. Morphological analysis confirmed functional data by showing persistent muscular AV connections in embryonic hearts. Interestingly, all myocardial AV connections stained positive for periostin, a nonmyocardial marker. Longitudinal analysis (HH35-44) demonstrated a decrease in both the number of hearts that exhibited premature base activation (P=0.015) and the number (P=0.004) and width (P=0.179) of accessory AV pathways with developmental stage in a similar time course. In the adult quail hearts, accessory myocardial AV pathways were functionally and morphologically absent. CONCLUSIONS: Thus, impulse propagation through persistent accessory AV connections remains possible at near-hatching stages (HH44) of development, which may provide a substrate for AV reentrant arrhythmias in perinatal life. Periostin positivity and absence of AV pathways in the adult heart suggest that these connections eventually lose their myocardial phenotype, which implicates ongoing AV ring isolation perinatally and postnatally
Koopman M, Antonini NF, Douma J, Wals J, Honkoop AH, Erdkamp FL, de Jong RS, Rodenburg CJ, Vreugdenhil G, Loosveld OJ, van Bochove A, Sinnige HA, Creemers GJ, Tesselaar ME, Slee PH, Werter MJ, Mol L, Dalesio O, Punt CJ . Sequential versus combination chemotherapy with capecitabine, irinotecan, and oxaliplatin in advanced colorectal cancer (CAIRO): a phase III randomised controlled trial. Lancet 2007; 370(9582):135-142.
Abstract: BACKGROUND: The optimum use of cytotoxic drugs for advanced colorectal cancer has not been defined. Our aim was to investigate whether combination treatment is better than sequential administration of the same drugs in patients with advanced colorectal cancer. METHODS: We randomly assigned 820 patients with advanced colorectal cancer to receive either first-line treatment with capecitabine, second-line irinotecan, and third-line capecitabine plus oxaliplatin (sequential treatment; n=410) or first-line treatment capecitabine plus irinotecan and second-line capecitabine plus oxaliplatin (combination treatment; n=410). The primary endpoint was overall survival. Analyses were done by intention to treat. This trial is registered with ClinicalTrials.gov with the number NCT00312000. FINDINGS: 17 patients (nine in the sequential treatment group, eight in the combination group) were found to be ineligible and were excluded from the analysis. 675 (84%) patients died during the study: 336 in the sequential group and 339 in the combination group. Median overall survival was 16.3 (95% CI 14.3-18.1) months for sequential treatment and 17.4 (15.2-19.2) months for combination treatment (p=0.3281). The hazard ratio for combination versus sequential treatment was 0.92 (95% CI 0.79-1.08; p=0.3281). The frequency of grade 3-4 toxicity over all lines of treatment did not differ significantly between the two groups, except for grade 3 hand-foot syndrome, which occurred more often with sequential treatment than with combination treatment (13%vs 7%; p=0.004). INTERPRETATION: Combination treatment does not significantly improve overall survival compared with the sequential use of cytotoxic drugs in advanced colorectal cancer. Thus sequential treatment remains a valid option for patients with advanced colorectal cancer
Koopmans CM, Bijlenga D, Aarnoudse JG, van Beek E, Bekedam DJ, van den Berg PP, Burggraaff JM, Birnie E, Bloemenkamp KW, Drogtrop AP, Franx A, de Groot CJ, Huisjes AJ, Kwee A, le Cessie S, van Loon AJ, Mol BW, van der Post JA, Roumen FJ, Scheepers HC, Spaanderman ME, Stigter RH, Willekes C, van Pampus MG. Induction of labour versus expectant monitoring in women with pregnancy induced hypertension or mild preeclampsia at term: the HYPITAT trial. BMC Pregnancy & Childbirth 2007; 7:14.
Abstract: ABSTRACT: BACKGROUND: Hypertensive disorders, i.e. pregnancy induced hypertension and preeclampsia, complicate 10 to15% of all pregnancies at term and are a major cause of maternal and perinatal morbidity and mortality. The only causal treatment is delivery. In case of preterm pregnancies conservative management is advocated if the risks for mother and child remain acceptable. In contrast, there is no consensus on how to manage mild hypertensive disease in pregnancies at term. Induction of labour might prevent maternal and neonatal complications at the expense of increased instrumental vaginal delivery rates and caesarean section rates. METHODS/DESIGN: Women with a pregnancy complicated by pregnancy induced hypertension or mild preeclampsia at a gestational age between 36+0 and 41+0 weeks will be asked to participate in a multi-centre randomised controlled trial. Women will be randomised to either induction of labour or expectant management for spontaneous delivery. The primary outcome of this study is severe maternal morbidity, which can be complicated by maternal mortality in rare cases. Secondary outcome measures are neonatal mortality and morbidity, caesarean and vaginal instrumental delivery rates, maternal quality of life and costs. Analysis will be by intention to treat. In total, 720 pregnant women have to be randomised to show a reduction in severe maternal complications of hypertensive disease from 12 to 6%. DISCUSSION: This trial will provide evidence as to whether or not induction of labour in women with pregnancy induced hypertension or mild preeclampsia (nearly) at term is an effective treatment to prevent severe maternal complications. TRIAL REGISTRATION: The protocol is registered in the clinical trial register number ISRCTN08132825
Korsse SE, van Es CA, Wessels PH. Hersenzenuwuitval als late complicatie van gecombineerde behandeling van radiosensitizer met chemotherapie. Tijdschrift voor neurologie & neurochirurgie 2007; 108(8):383-388.
Krediet TG, Wiertsema SP, Vossers MJ, Hoeks SB, Fleer A, Ruven HJ, Rijkers GT. Toll-like receptor 2 polymorphism is associated with preterm birth. Pediatric research 2007; 62(4):474-476.
Abstract: Evidence is increasing for a role of polymorphisms in maternal or fetal innate immune response genes in preterm birth. Toll-like receptors (TLRs) are important receptors in the innate immunity. The genotype distribution of two TLR2 single nucleotide polymorphisms (SNPs) and one TLR4 SNP were determined among 524 neonates and associated with gestational age (GA). Genomic DNA was isolated from prospectively collected blood samples and polymorphisms in TLR2 (T-16934A, RS4696480 and Arg753Gln, RS5743708) and TLR4 (Thr399Ile, RS4986791) were determined using sequence specific primers by PCR. Allele frequencies of two TLR2 SNPs and one TLR4 SNP were analyzed according to prematurity. Analysis among 305 infants, after exclusion of infants born after multiple pregnancy or because of preeclampsia, revealed significantly shorter GAs for infants carrying two polymorphic TLR2 alleles (-16934TA/AA and 753ArgGln/GlnGln) compared with infants carrying one polymorphic and one wild-type allele or two wild-type alleles (median GA 30.6 wk versus 34.1-36.8 wk, respectively, p < 0.02). Carriage of two variant TLR2 alleles potentially leads to aberrant innate immune responses, which may have contributed to very preterm birth
Krekels EH, van den Anker JN, Baiardi P, Cella M, Cheng KY, Gibb DM, Green H, Iolascon A, Jacqz-Aigrain EM, Knibbe CA, Santen GW, van Schaik RH, Tibboel D, la Pasqua OE. Pharmacogenetics and paediatric drug development: issues and consequences to labelling and dosing recommendations. Expert Opinion on Pharmacotherapy 2007; 8(12):1787-1799.
Abstract: The area of pharmacogenetics (PGt) is evolving rapidly. However, ongoing efforts in this field are not aligned with the requirements for the inclusion of clinically relevant findings into the label, especially with reference to paediatric indications. Clinical research in children poses unique issues from a practical and technical perspective, but many challenges can be overcome by applying advanced study design and data analysis methods. When investigating the role of PGt factors on treatment effect, all features that influence drug response must be taken into account. Yet, PGt often has a privileged status in research protocols, with PGt factors evaluated independently from other determinants of response, instead of being regarded as other demographic or clinical covariates (e.g., age, renal function). At present, guidelines to incorporate PGt findings into label statements are lacking in part because this is a new and incompletely understood area. This situation is no longer acceptable. To achieve the potential that PGt can offer to drug development and ultimately to drug prescription, academia, industry and regulatory agencies need to pool resources on the revision of study design and data analysis requisites, bringing in model-based methodologies to enable accurate interpretation of results and provide appropriate labelling recommendations
Kropman RH, van Santvoort HC, Teijink J, van de Pavoordt HD, Belgers HJ, Moll FL, de Vries JP. The medial versus the posterior approach in the repair of popliteal artery aneurysms: A multicenter case-matched study. Journal of Vascular Surgery 2007; 46(1):24-30.
Abstract: OBJECTIVES: This study was conducted to compare the early and mid-term results of the medial and posterior approaches in the surgical treatment of popliteal artery aneurysms (PAAs). METHODS: From 1992 to 2006 in three hospitals, 110 popliteal aneurysms needed surgical repair by a posterior or a medial approach. Of 36 aneurysms repaired by the posterior approach, 33 could be case-matched to a medially excluded PAA according to the criteria of (1) patient age, (2) cardiovascular comorbidity, (3) indication for PAA repair, (4) diameter of PAA at time of surgical repair, (5) number of distal outflow vessels at time of surgical repair, and (6) type of bypass or interposition graft (venous or polytetrafluoroethylene). RESULTS: During the 30-day postoperative period, seven complications (21%) occurred in each group, no patients died, and no amputations were necessary. Two patients in the posterior group vs none in the medial group (P < .05) needed thrombectomy because of occlusion of the reconstruction. The mean follow-up was 47 months (range, 2 to 176). In this period, 13 deaths occurred, but none were related to the previous interventions. The primary patency rates at 6 months and at 1, 3, and 4 years were 84%, 79%, 66%, and 66% in the posterior group and 96% (P < .05), 93% (P < .05), 76% (P = NS), and 69 % (P = NS) for the medial group, respectively. The secondary patency rates at 6 months, and at 1, 3, and 4 years were 100%, 100%, 100%, and 90% in the posterior group and 96%, 96%, 96%, and 90% in the medial group, respectively (P = NS). Limb salvage rates were 97% for the posterior group and 100% for the medial group (P = NS). No neurologic complications or venous damage was seen in either group. Irrespective of approach, venous reconstructions resulted in significantly higher patency rates compared with prosthetic reconstructions at the 3-year follow-up (84% vs 67%, P < .01). During follow-up, which included duplex scanning, two patients in the medial group needed renewed surgical intervention and posterior exclusion because of persistent flow and growth of the native aneurysm. CONCLUSION: Early (<1 year) primary patency rates of the medial approach were significantly better than the posterior approach, possibly because of the limited posterior exposure. However, in the absence of a significant difference in long-term primary and secondary patency rates between the posterior and medial approach, and considering the substantial risk of aneurysm growth after medial approach (up to 22%), the posterior approach might be the surgical method of preference for PAA repair in the long run
Kropman RH, de Vries JP, Moll FL. Surgical and endovascular treatment of atherosclerotic popliteal artery aneurysms. Journal of Cardiovascular Surgery 2007; 48(3):281-288.
Abstract: Popliteal artery aneurysms are the most common peripheral aneurysms. Patients with unrecognized aneurysms may present with acute limb ischemia and considerable threat for limb loss due to thromboembolic complications. This article reviews short-term and long-term results of surgical and endovascular treatment for mainly elective repair of popliteal artery aneurysms. A systemic review was conducted of data in the English literature from 1990. The review included 1 prospective randomized trial, 6 prospective studies, and 42 retrospective studies on the management of popliteal artery aneurysms. These studies contained 2 197 patients with 2 882 popliteal artery aneurysms. Short-term results are acceptable, with average 1-year patency rates of 90% for surgical treatment and 75% for endovascular treatment, and respective limb salvages rates of 95% and 100%. Endovascular treatment lacks long-term follow-up, whereas venous surgical repair has an average 5-year patency rate of up to 85% (prosthetic grafts, 40-80%). There is a need for randomized trials comparing long-term results of surgical versus endovascular treatment of popliteal artery aneurysms. So far, long-term results of elective surgical repair for popliteal artery aneurysms are acceptable if venous grafts are used. In any case, acute repair of popliteal artery aneurysms must be avoided
Kruit A, Grutters J, van Moorsel CM, van den Bosch JJM, Ruven HJT. YKL-40 outperforms the genotype-corrected angiotensin-converting enzyme (ACE) as a diagnostic marker for sarcoidosis. American Journal of Respiratory & Critical Care Medicine 2007; 175:A364.
Kruit A, Grutters JC, Gerritsen WB, Kos S, Wodzig WK, van den Bosch JM, Ruven HJ. ACE I/D-corrected Z-scores to identify normal and elevated ACE activity in sarcoidosis. Respiratory Medicine 2007; 101(3):510-515.
Abstract: BACKGROUND: The value of elevated serum angiotensin-converting enzyme (ACE) activity in the diagnosis and follow-up in sarcoidosis is a matter of ongoing debate. This may be at least related to the insertion (I)/deletion (D) polymorphism in the ACE gene (ACE I/D). ACE activity is influenced by the ACE I/D polymorphism. As a consequence, the use of one reference interval instead of three genotype-specific reference intervals for ACE activity may lead to a less precise interpretation of ACE activity. METHODS: In order to assess whether determination of ACE activity indeed requires the ACE I/D genotype to be taken into account, we established ACE I/D-corrected reference intervals in healthy, Caucasian volunteers (n=200). In addition, ACE activities in ACE I/D genotyped patients suspected of or having sarcoidosis (n=129) were expressed as the Z-score related to ACE I/D-corrected reference intervals. RESULTS: Comparison of the Z-score with ACE activity in which ACE I/D is ignored rendered 8.5% misclassification of 'elevated' versus 'normal' ACE or vice versa. CONCLUSIONS: Our data demonstrate a convenient way to circumvent the use of three reference intervals by introducing a Z-score for ACE activity. It also illustrates the need to re-investigating the possible clinical value of serum ACE activity in sarcoidosis by considering ACE I/D
Kruit A, Grutters JC, Ruven HJ, van Moorsel CC, van den Bosch JM. A CHI3L1 gene polymorphism is associated with serum levels of YKL-40, a novel sarcoidosis marker. Respiratory Medicine 2007; 101(7):1563-1571.
Abstract: BACKGROUND: YKL-40, a chitinase-like cartilage glycoprotein, has recently shown its potential as a marker for sarcoidosis. METHODS: This study aimed to assess whether YKL-40 at presentation may predict the course of sarcoidosis over a 4-year follow-up period and to investigate whether polymorphisms in the chitinase 3-like 1 (CHI3L1) gene might influence serum YKL-40 levels in sarcoidosis patients (n=63) and controls (n=333). RESULTS: Patients had significantly higher (mean, 95% CI) serum YKL-40 levels (181.3ng/ml, 50.7-648.1) compared to controls (36.6ng/ml, p<0.0001. Serum YKL-40 was elevated in 79% of the patients and was inversely correlated with DLco at presentation (r(2)=-0.27, p=0.03), but not after 2-4 years of follow-up (r(2)=-0.16, p=0.27). Serum YKL-40 levels in controls were dependent on the CHI3L1 -329 G/A polymorphism (mean, 95% CI): GG (n=213) 48.3ng/ml, 41.7-56.0; GA (n=101) 31.2ng/ml, 26.6-36.3; AA (n=17) 17.8ng/ml, 13.6-23.4, p<0.0001. In patients, this effect was not observed. CONCLUSIONS: YKL-40 may be used as a sarcoidosis disease marker, but it is unsuitable as a marker to predict the course of the disease. The CHI3L1 -329 G/A polymorphism contributes to inter-individual variations of YKL-40 levels, but does not influence sarcoidosis disease susceptibility or severity
Kruit A, Ruven HJ, Grutters JC, van Moorsel CM, van den Bosch JM. The -326 G/A promoter polymorphism in the chitinase 3-like 1 gene is associated with serum levels of YKL-40, a novel sarcoidosis marker. American Journal of Respiratory & Critical Care Medicine 2007; 175:A364.
Kurvers MJM, Braam RL, Verzijlbergen JF, Heestermans AACM, ten Berg JM. Myocardial salvage in STEMI patients treated with primary coronary angioplasty as demonstrated by myocardial SPECT. Netherlands Heart Journal 2007; 15(12):422-423.
Lammers J-WJ. Respiratoire insufficiëntie en cor pulmonale, inclusief SAS. In: van den Bosch JMM, Bottema BJAM, Lammers J-WJ, Zaagsma J, editors. Het pulmonaal formularium : een praktische leidraad. Houten: Bohn Stafleu Van Loghum, 2007: 62-75.
Lammers J-WJ, van der Zee JS. Door geneesmiddelen, beroep of hobby veroorzaakte longaandoeningen. In: van den Bosch JMM, Bottema BJAM, Lammers J-WJ, Zaagsma J, editors. Het pulmonaal formularium : een praktische leidraad. Houten: Bohn Stafleu Van Loghum, 2007: 183-190.
Leclercq E. Letter to the editor. Journal of the Medical LIbrary Association (JMLA) 2007; 95(2):118-119.
Lewiszong-Rutjens CA, Rechards M, Schipper JA. Chemische pneumonie na ingestie van lampolie. Nederlands Tijdschrift voor Geneeskunde 2007; 151(33):1836-1838.
Abstract: A 20-months-old girl developed a cough and became drowsy after drinking lamp oil. In the Emergency Ward, her oxygen saturation was 85%. The day after admission to hospital she showed a clinical and radiological picture of chemical pneumonia. After 3 days the patient could be discharged in good condition. The most important symptoms after the ingestion of hydrocarbon compounds such as lamp oil are respiratory problems due to aspiration and effects on the central nervous system following gastrointestinal absorption. Severe symptoms can develop in a short period of time. The treatment is supportive. The prognosis is favourable
Lindeman JH, Pijl H, Toet K, Eilers PH, van Ramshorst B, Buijs MM, van Bockel JH, Kooistra T. Human visceral adipose tissue and the plasminogen activator inhibitor type 1. International Journal of Obesity 2007; 31(11):1671-1679.
Linsen MA, Vos AW, Vos JA, Wisselink W. Carotid artery dynamics after carotid angioplasty and stenting. Expert Review of Cardiovascular Therapy 2007; 5(2):195-199.
Abstract: Carotid angioplasty and stenting (CAS) has emerged as an alternative treatment for carotid artery occlusive disease. As initial results in patients with an increased surgical risk appeared promising, the popularity of CAS has increased substantially over the last years and CAS has more often been advocated as an alternative to the gold standard, carotid endarterectomy (CEA). Several controlled trials comparing CAS with CEA are currently being conducted. However, long-term results of CAS are still sparse and several issues regarding the inherent differences between treatment modalities have not yet been elucidated. Interestingly, to date, very little attention has been directed towards the mobile features of the carotid artery and the implications of stent placement on carotid artery dynamics
Los M, Roodhart JML, Voest EE. Target Practice: Lessons from Phase III Trials with Bevacizumab and Vatalanib in the Treatment of Advanced Colorectal Cancer. Oncologist 2007; 12(4):443-450.
Abstract: Vascular endothelial growth factor (VEGF) is one of the most important factors involved in tumor angiogenesis and has become an important target for anticancer treatment. In 2004, this approach was validated in a randomized, controlled phase III clinical trial. It was shown that the addition of bevacizumab, a humanized monoclonal antibody against VEGF-A, to conventional chemotherapy prolonged survival over chemotherapy alone in patients with metastatic colorectal cancer. In this review, we discuss the results of the clinical trials that have led to the incorporation of antiangiogenic agents into the treatment of patients with advanced colorectal cancer. We limit ourselves to the two agents that have been tested extensively in phase III trials: bevacizumab and vatalanib, a small molecule tyrosine kinase inhibitor against VEGF receptors. In addition, we discuss the adverse effects of bevacizumab and vatalanib and the clinical management of the side effects. Disclosure of potential conflicts of interest is found at the end of this article
Louz CM, Abrahamse CA. Verplegen van zorgvragers voor en na een chirurgische ingreep, onderzoek of behandeling (deelkwalificatie 406). 2e herz. ed. Baarn: NijghVersluys, 2007.
Luderer R, Buisman A, van Hannen EJ, van der Zee A, Kortlandt W, Hermans MHA, van Houte AJ. Real-time HLA-B27 detection: a clinical validation for the Dutch population. 17th IFCC-FESCC European Congress of Clinical Chemistry and Laboratory Medicine Amsterdam, 3-7 juni 2007.
Luiking ML. Kaliumchloride-infuus op de IC; "physician driven" versus een " nurse driven" algoritme. Verpleegkunde 2007; 22(4):216.
Lundh A, Kremer LCM, Leclercq E. Tips and tricks for understanding and using SR results. No. 6: development of a search strategy. Evidence-Based Child Health: A Cochrane Review Journal 2007; 2(2):937-939.
Lutgendorff F, Sandström PA, Trulsson LM, van Minnen LP, Rijkers GT, Timmerman HM, Gooszen HG, Akkermans LMA, Söderholm JD. Prophylactic probiotics reduce intestinal permeability in early phase experimental pancreatitis. 7th world Congress of the International Hepato-Pancreato-Biliary Association, 3-7 September 2006, Edinburgh, Scotland 2007.
Maas KW, El Sharouni SY, Smit EF, Schramel FM. Sequencing chemotherapy, radiotherapy and surgery in combined modality treatment of stage III nonsmall cell lung cancer. Current Opinion in Pulmonary Medicine 2007; 13(4):297-304.
Abstract: PURPOSE OF REVIEW: Combined modality treatment is nowadays the standard of care in stage III nonsmall cell lung cancer, but the overall survival is still poor. Therefore, the challenge for clinicians is to optimize the combination of the treatment modalities. The review will focus on bimodality and trimodality approaches in stage III nonsmall cell lung cancer. Although the role of surgical resection in combined modality treatment is unclear, surgery will be discussed as a potential part of the treatment approach. RECENT FINDINGS: Concurrent chemoradiotherapy has proven to be more effective than chemotherapy followed by radiotherapy. Full-dose consolidation chemotherapy after concurrent chemoradiation showed an improvement of survival in some studies. Consolidation chemotherapy is, however, difficult to administer owing to its toxicity in these complex regimens. Both the Eastern Cooperative Oncology Group and the Radiation Therapy Oncology Group showed similar survival after surgery compared to sequential or concurrent chemoradiotherapy; however, pneumonectomies and residual malignant mediastinal disease after induction treatment had a negative impact on survival. SUMMARY: Concurrent chemoradiotherapy in combination with full-dose chemotherapy should be the standard of care for nonsmall cell lung cancer stage IIIA/B. Surgery is still experimental, but seems to be promising for certain subgroups of patients. More research has to be done in optimizing radiotherapy schedules and chemotherapy schemes in order to minimize toxicity. Novel therapeutics have to be introduced in the combined modality approach of stage III nonsmall cell lung cancer
Maas KW, Phernambucq EC, Sharouni SY, Stigt JA, Groen HJ, van den Borne BE, Senan S, Smit EF, Paul RA, Schramel FM. A phase II study of weekly docetaxel/cisplatin and concurrent radiotherapy followed by surgery in patients with stage III non-small cell lung cancer (NSCLC). Journal of Clinical Oncology 2007; 25(18 suppl):18050.
Macaré van Maurik AF, Stubenitsky BM, van Swieten HA, Duurkens VA, Laban E, Kon M. Use of tissue expanders in adult postpneumonectomy syndrome. Journal of Thoracic & Cardiovascular Surgery 2007; 134(3):608-612.
Abstract: OBJECTIVE: Mediastinal shift and rotation after pneumonectomy can lead to severe symptomatic airway compression. Historically, a variety of treatments, such as muscle-flap transposition, pericardial fixation, and plombage, have been used. In this study we retrospectively evaluated the effectiveness of intrathoracic tissue expansion in postpneumonectomy syndrome. METHODS: Since 1990, our center has used tissue expanders as plombage in patients with postpneumonectomy syndrome. Between 1990 and 2005, a total of 20 patients were treated. The outcome was evaluated by using preoperative, perioperative, and postoperative bronchoscopy and imaging studies. Patient satisfaction was determined with a validated questionnaire. RESULTS: In 19 of the 20 patients, up to 3 tissue expanders were placed and filled within the pleural cavity. Access to the pleural cavity could not be obtained in 1 patient because of adhesions. Perioperative and postoperative bronchoscopic scans demonstrated decompression of the left main bronchus in 16 (84%) of 19 patients. On discharge, all patients reported improvement of their respiratory symptoms. Six (32%) patients required reoperation because of herniation (n = 2), luxation (n = 1), inadequate positioning (n = 2), and leakage of the tissue expander (n = 4). In 4 patients additional filling was performed in the outpatient clinic, with immediate improvement of respiratory distress. CONCLUSION: Use of tissue expanders in adults with postpneumonectomy syndrome is an effective means of decompressing the remaining bronchus, thereby leading to a significant improvement in respiratory symptoms. Although 32% of patients required reoperation for complications, each complication was readily correctable
Mallant M, Hadithi M, Al-Toma AB, Kater M, Jacobs M, Manoliu R, Mulder C, van Waesberghe JH. Abdominal computed tomography in refractory coeliac disease and enteropathy associated T-cell lymphoma. World journal of gastroenterology 2007; 13(11):1696-1700.
Abstract: AIM: To evaluate computed tomography (CT) findings, useful to suggest the presence of refractory celiac disease (RCD) and enteropathy associated T cell lymphoma (EATL). METHODS: Coeliac disease (CD) patients were divided into two groups. Group I: uncomplicated CD (n = 14) and RCD type I (n = 10). Group II: RCD type II (n = 15) and EATL (n = 7). RESULTS: Both groups showed classic signs of CD on CT. Intussusception was seen in 1 patient in group I vs 5 in group II (P = 0.06). Lymphadenopathy was seen in 5 patients in group II vs no patients in group I (P = 0.01). Increased number of small mesenteric vessels was noted in 20 patients in group I vs 11 in group II (P = 0.02). Eleven patients (50%) in group II had a splenic volume < 122 cm3 vs 4 in group I (14%), 10 patients in group I had a splenic volume > 196 cm3 (66.7%) vs 5 in group II (33.3%) P = 0.028. CONCLUSION: CT scan is a useful tool in discriminating between CD and (Pre) EATL. RCD II and EATL showed more bowel wall thickening, lymphadenopathy and intussusception, less increase in number of small mesenteric vessels and a smaller splenic volume compared with CD and RCD I
Mallée M. 'Fast track in de cardiochirurgie': snelle preoperatieve screening, coördinatie door nurse practitioner. Cordiaal 2007; 28(1):21-23.
Mattace-Raso FU, van den Meiracker AH, Bos WJ, van der Cammen TJ, Westerhof BE, Elias-Smale S, Reneman RS, Hoeks AP, Hofman A, Witteman JC . Arterial stiffness, cardiovagal baroreflex sensitivity and postural blood pressure changes in older adults: The Rotterdam Study. Journal of Hypertension 2007; 25(7):1421-1426.
Abstract: OBJECTIVE: Arterial stiffness may be involved in the impairment of the arterial baroreflex. In the present study the associations between arterial stiffness and cardiovagal baroreflex sensitivity (BRS) and between BRS and postural blood pressure (BP) changes were investigated within the framework of the Rotterdam Study. METHODS: Arterial stiffness was determined by aortic pulse wave velocity and the carotid distensibility coefficient. Continuous recording of the R-R interval and finger BP was performed with the subject resting supine, and BRS was estimated from the spontaneous changes in systolic BP and corresponding interbeat intervals. Measures of aortic stiffness or carotid distensibility and BRS were available in 2490 and 2083 subjects, respectively. The association between arterial stiffness and ln BRS was investigated by multivariate linear regression analysis and then by analysis of covariance, comparing BRS by quartiles of arterial stiffness. RESULTS: The mean age of the subjects was 71.7 +/- 6.6 (41.7% men). Aortic stiffness was negatively associated [beta = -0.029; 95% confidence interval (CI): -0.040, -0.019] and the carotid distensibility coefficient positively associated with BRS (beta = 0.017; 95% CI: 0.010, 0.024). An orthostatic decrease in systolic BP was absent in 1609 subjects, between 1 and 10 mmHg in 502 and >10 mmHg in 269 subjects, with corresponding mean values (95% CI) of ln BRS of 1.47 (1.44-1.51), 1.43 (1.37-1.49) and 1.36 (1.28-1.44) ms/mmHg (test for trend P < 0.019). An orthostatic decrease in diastolic BP was absent in 1123 subjects, 1-10 mmHg in 1057 and >10 mmHg in 209 subjects, with corresponding mean values of ln BRS of 1.49 (1.45-1.53), 1.41 (1.37-1.45) and 1.45 (1.36-1.54) ms/mmHg (P < 0.04). CONCLUSION: In a large population of older subjects, arterial stiffness appears to be an independent determinant of impaired BRS. Within the same population, impaired BRS was associated with orthostatic BP changes
McCann GP, van Dockum WG, Beek AM, Nijveldt R, ten Cate FJ, ten Berg JM, van Rossum AC. Extent of myocardial infarction and reverse remodeling assessed by cardiac magnetic resonance in patients with and without right bundle branch block following alcohol septal ablation for obstructive hypertrophic cardiomyopathy. American Journal of Cardiology 2007; 99(4):563-567.
Abstract: Percutaneous alcohol septal ablation (ASA) is an established technique for the relief of refractory symptoms in patients with obstructive hypertrophic cardiomyopathy. Most subjects develop right bundle branch block (RBBB) after ASA, but it is not known whether these patients have similar infarct characteristics, which may influence left ventricular (LV) pressure gradient reduction and reverse remodeling, compared with those without RBBB. Twenty-seven consecutive patients (15 men, 12 women; mean age 62 +/- 16 years) were studied with electrocardiography and cardiac magnetic resonance imaging at baseline and 1 and 6 months (n = 25) after ASA. Infarct size and location were determined at 1 month by delayed contrast-enhanced cardiac magnetic resonance imaging. The 17 subjects who developed RBBB tended to have larger infarcts (creatine kinase-MB 251 +/- 92 vs 148 +/- 97 IU, p = 0.03; cardiac magnetic resonance imaging mass 22.5 +/- 9.3 vs 16.6 +/- 8.3 g, p = 0.1) and were more likely to have sustained anterior and inferior septal transmural infarctions (9 of 17 vs 1 of 10, p = 0.03) than those without RBBB. Those who developed RBBB had greater LV mass reductions at 6 months (46 +/- 26 vs 29 +/- 13 g, p = 0.04) despite similar reductions in LV pressure gradients (64 +/- 31 vs 56 +/- 32 mm Hg). In conclusion, patients who develop RBBB after ASA tend to have more extensive transmural septal infarctions and greater reverse remodeling than those without RBBB
McMillan DJ, Geffers R, Buer J, Vlaminckx BJ, Sriprakash KS, Chhatwal GS. Variations in the distribution of genes encoding virulence and extracellular proteins in group A streptococcus are largely restricted to 11 genomic loci. Microbes and infection 2007; 9(3):259-270.
Abstract: Group A streptococcus (GAS) is a human pathogen associated with a wide range of human diseases that vary in symptoms and clinical severity. In this report we describe the use of a targeted low density array representing genes encoding classical virulence factors, purported virulence factors and other extracellular proteins to examine differences in the genetic profiles of 68 clinical GAS isolates. Of the 226 genes on the array (encoding 217 virulence factors or putative extracellular proteins and nine positive control house-keeping proteins) 62 had distributions that were statistically associated with specific GAS M-types. While 32 of these genes were bacteriophage related, the remaining 30 have not previously been described as bacteriophage associated. We show that these 'non-bacteriophage related' genes are found in 11 loci located in five greater chromosomal regions, often near classical GAS virulence factors, and often accompanied by genes associated with mobile genetic elements (MGEs). Many of these loci also demonstrated genetic variation within strains of the same M-type, suggesting these regions to be recombinatorial and mutational hotspots. Evidence for acquisition of genes from other species is also apparent in these loci. Our data suggests that imprecise recombination events involving MGEs not only result in acquisition of new genes, but can also result in deletion of flanking chromosomal genes. Thus MGE related events would appear to be the major contributor to variation of discrete virulence loci, which could account for the disease causing propensity of individual strains. We believe that profiling of the 11 loci could be a meaningful tool in epidemiological GAS typing studies
Meijer BU, de Waard-van der Spek FB. Allergic contact dermatitis because of topical use of 5-fluorouracil (Efudix® cream). Contact Dermatitis 2007; 57(1):58-60.
Meijer P, Haas F, Kluft C. Quantification of the measurement uncertainty for D-dimer assay results around the cut-off level: improved decision rules required? Journal of Thrombosis & Haemostasis 2007; 5(Suppl 2):P-T-526.
Meijvis SC, Endeman H, Geers AB, ter Borg EJ. Extremely high serum ferritin levels as diagnostic tool in adult-onset Still's disease. Netherlands Journal of Medicine 2007; 65(6):212-214.
Abstract: The diagnosis of adult-onset Still's disease (ASD ) is difficult to establish due to the nonspecific clinical and laboratory findings. A markedly raised serum ferritin level is a typical finding, although it is not well understood why ferritin levels are extremely high in ASD . We discuss several possible explanations leading to the extremely high levels of ferritin
Meiland R, Stolk RP, Geerlings SE, Peeters PH, Grobbee DE, Coenjaerts FE, Brouwer EC, Hoepelman AI. Association between Escherichia coli bacteriuria and renal function in women: long-term follow-up. Archives of Internal Medicine 2007; 167(3):253-257.
Abstract: BACKGROUND: We sought to investigate whether Escherichia coli bacteriuria is associated with a decline in renal function or with the development of end-stage renal failure after long-term follow-up. METHODS: We performed a full cohort analysis for women who participated in 2 population-based studies. The baseline cohort consisted of women who collected morning midstream urine samples that were stored. In the cohort study, the presence of E coli bacteriuria was subsequently determined by real-time polymerase chain reaction. After a mean +/- SD follow-up of 11.5 +/- 1.7 years, blood samples were drawn from 490 women. In the nested case-control study, cases comprised all women who underwent kidney therapy (hemodialysis or renal transplantation) between participation in the baseline cohort study and a mean +/- SD of 13.8 +/- 7.4 years later. RESULTS: The mean +/- SD age at baseline was 45.0 +/- 3.2 years, and 48 women (10%) had E coli bacteriuria. After 11.5 years, the mean +/- SD creatinine clearance (Cockroft-Gault formula) was similar between the 2 groups (87 +/- 21 mL/min [1.5 +/- 0.4 mL/s] and 85 +/- 18 mL/min [1.4 +/- 0.3 mL/s] for women who had and those who did not have bacteriuria, respectively). In the nested case-control study, the prevalence of E coli bacteriuria was 14% among cases and control subjects. The odds ratio corrected for age for the development of end-stage renal failure in the presence of E coli bacteriuria at baseline was 1.1 (95% confidence interval, 0.4-2.8; P = .86). CONCLUSION: Escherichia coli bacteriuria is not associated with a decline in renal function or with the development of end-stage renal failure in a population of generally healthy women during 12 to 14 years of follow-up
Meinders A-J, Meinders AE. Hyponatriëmie tijdens een duurloop: door overmatige vochtinname. Nederlands Tijdschrift voor Geneeskunde 2007; 151(10):581-587.
Meinders A-J, Gerritsen K, Wesselink RMJ. Diagnostic value of [18F]fluoro-deoxyglucose positron emission tomography on the ICU. 19e Internistendagen : abstractboek :25, 26 & 27 april 2007 MECC Maastricht 2007;123.
Meinders AJ, Schepens MA. Diagnose in beeld (307). Een man met dysfagie. Nederlands Tijdschrift voor Geneeskunde 2007; 151(3):184.
Abstract: A 51-year-old man suffered from longstanding dysphagia due to a large aneurysm of the thoracoabdominal aorta
Mink van der Molen AB. Een kleine imperfectie : geïsoleerde schisis geen reden voor abortus. Medisch Contact 2007; 62(6):1116-1119.
Moll FL, Neumann HAM. Alsmaar strippen. Medisch Contact 2007; 38(21):1554-1557.
Mosselman MJ. Ondervoeding bij CVA-patiënten in het ziekenhuis. Utrecht: Universiteit Utrecht, 2007.
Muris JJ, Ylstra B, Cillessen SA, Ossenkoppele GJ, Kluin-Nelemans JC, Eijk PP, Nota B, Tijssen M, de Boer WP, van de Wiel M, van den IJssel PR, Jansen P, de Bruin PC, van Krieken JH, Meijer GA, Meijer CJ, Oudejans JJ. Profiling of apoptosis genes allows for clinical stratification of primary nodal diffuse large B-cell lymphomas. British Journal of Haematology 2007; 136(1):38-47.
Abstract: Intrinsic resistance of lymphoma cells to apoptosis is a probable mechanism causing chemotherapy resistance and eventual fatal outcome in patients with diffuse large B cell lymphomas (DLBCL). We investigated whether microarray expression profiling of apoptosis related genes predicts clinical outcome in 46 patients with primary nodal DLBCL. Unsupervised cluster analysis using genes involved in apoptosis (n = 246) resulted in three separate DLBCL groups partly overlapping with germinal centre B-lymphocytes versus activated B-cells like phenotype. One group with poor clinical outcome was characterised by high expression levels of pro-and anti-apoptotic genes involved in the intrinsic apoptosis pathway. A second group, also with poor clinical outcome, was characterised by high levels of apoptosis inducing cytotoxic effector genes, possibly reflecting a cellular cytotoxic immune response. The third group showing a favourable outcome was characterised by low expression levels of genes characteristic for both other groups. Our results suggest that chemotherapy refractory DLBCL are characterised either by an intense cellular cytotoxic immune response or by constitutive activation of the intrinsic mediated apoptosis pathway with concomitant downstream inhibition of this apoptosis pathway. Consequently, strategies neutralising the function of apoptosis-inhibiting proteins might be effective as alternative treatment modality in part of chemotherapy refractory DLBCL
Nguyen DT, Citgez E, van Brussel BL, Vermeulen FE, Plokker HW, Voors AA. Systolic blood pressure and cardiac mortality over 24 years after venous coronary bypass surgery. Journal of Human Hypertension 2007; 21(4):330-332.
Niermeijer JM, Eurelings M, van der Linden MW, Lokhorst HM, Franssen H, Fischer K, Teunissen LL, van den Berg LH, Schobben F, Wokke JH, Notermans NC. Intermittent cyclophosphamide with prednisone versus placebo for polyneuropathy with IgM monoclonal gammopathy. Neurology 2007; 69(1):50-59.
Abstract: BACKGROUND: The best treatment for polyneuropathy associated with IgM monoclonal gammopathy (MGUS) is unknown. Oral cyclophosphamide combined with prednisone showed limited efficacy in a previous open label pilot study. We therefore performed a double-blind, randomized, placebo-controlled study of combined oral cyclophosphamide and prednisone in IgM MGUS polyneuropathy. METHODS: Thirty-five patients with progressive IgM MGUS polyneuropathy were included. After stratification for anti-MAG antibodies patients were randomized to oral cyclophosphamide 500 mg once daily for 4 days combined with oral prednisone 60 mg once daily for 5 days (treatment) (n = 16), or placebo (n = 19), repeated every 28 days for six times. Primary outcome was improvement of the Rivermead Mobility Index (RMI). Secondary outcomes were improvement of the modified Rankin scale, Medical Research Council and sensory sum scores, levels of M protein, EMG, and Short Form-36 scale after treatment. Patients were examined at 0, 6, 12, 18, and 24 months. RESULTS: After 6 months of treatment and at later follow-up, no difference in change of the RMI between the two groups was observed. Change of the Rankin scale was similar in both groups. Other outcome parameters showed more improvement in the treatment group: the MRC sum score improved more from 6 to 24 months after treatment; the sensory sum score improved more at 6 months; the SF 36 mean health change score and physical role score improved more; and the median nerve distal conduction (abductor pollicis brevis muscle) improved more in the treatment group. The most common adverse event was nausea. CONCLUSIONS: Compared with placebo treatment, this first double-blind randomized trial with cyclophosphamide and prednisone in IgM MGUS polyneuropathy showed no beneficial effect on the functional scales, but a beneficial effect on muscle strength and sensation was observed
Niers L, Stasse-Wolthuis M, Rombouts FM, Rijkers GT. Nutritional support for the infant's immune system. Nutrition reviews 2007; 65(8 Pt 1):347-360.
Abstract: Newborn babies possess a functional but immature immune system as a defense against a world teeming with microorganisms. Breast milk contains a number of biological, active compounds that support the infant's immune system. These include secretory immunoglobulin A (IgA), which confers specific protection against enteric pathogens, as well as numerous other immunological, active ingredients. A number of these ingredients can be used as supplements for infant formulas based on cow's milk. Here, the strength of evidence regarding the immune-stimulating effects of selected minerals, vitamins, fatty acids, pre- and probiotics, and nucleotides is reviewed. An assessment of how these ingredients are used in infant-formula products currently available on the market is also presented
Niers LE, Hoekstra MO, Timmerman HM, van Uden NO, de Graaf PM, Smits HH, Kimpen JL, Rijkers GT. Selection of probiotic bacteria for prevention of allergic diseases: immunomodulation of neonatal dendritic cells. Clinical & Experimental Immunology 2007; 149(2):344-352.
Abstract: Modification of intestinal microbiota early in life by administration of probiotic bacteria may be a potential approach to prevent allergic disease. To select probiotic bacteria for in vivo purposes, we investigated the capacity of probiotic bacteria to interact with neonatal dendritic cells (DC) and studied the ensuing T cell polarizing effect. Immature DC were generated from cord blood-derived monocytes and maturation was induced by maturation factors (MF), lipopolysaccharide (LPS) plus MF and Bifidobacterium bifidum, B. infantis, Lactobacillus salivarius, Lactococcus lactis alone or combined with MF. After 12 days of co-culture with DC and Staphylococcus aureus enterotoxin B (SEB) as antigenic stimulus, cytokine production by autologous T cells was determined by intracellular cytokine staining. Additionally, cells were stimulated with CD3 and CD28 monoclonal antibodies and cytokines were measured in supernatants by multiplex assay. The probiotic strains induced partial maturation of DC. Full maturation of DC was induced for all strains tested when MF was added. The percentage of interleukin (IL)-4 producing T cells was lower in T cell cultures stimulated with B. bifidum matured DC compared to MF and LPS matured DC, which coincided with a higher percentage of interferon (IFN)-gamma-producing T cells. Furthermore, T cells stimulated by B. bifidum matured DC produced significantly more IL-10 compared to MF matured DC. Selected species of the Bifidobacterium genus prime in vitro cultured neonatal DC to polarize T cell responses and may therefore be candidates to use in primary prevention of allergic diseases
Niers T, Rijkers G, Hoekstra M. Gezonde bacteriën in de strijd tegen eczeem. Effect probiotica onderzocht bij moeder en kind. Pharmaceutisch Weekblad 2007; 142(1):41-43, 64.
Nieuwenhuizen L, Biesma DH. CNS myelomatosis : a case report and review of the literature. 19e Internistendagen : abstractboek :25, 26 & 27 april 2007 MECC Maastricht 2007;76-77.
Noordzij M, Boeschoten EW, Bos WJ, Dekker FW, Bossuyt PM, Krediet RT, Korevaar JC, for the NECOSAD Study Group. Disturbed mineral metabolism is associated with muscle and skin complaints in a prospective cohort of dialysis patients. Nephrology Dialysis Transplantation 2007; 22(10):2944-2949.
Abstract: Background. Disturbed mineral metabolism is associated with increased morbidity and mortality, however, its influence on physical symptoms is less clear. We explored the effects of disordered plasma calcium, phosphorus, calcium-phosphorus (Ca x P) product and intact parathyroid hormone (iPTH) concentrations according to the K/DOQI guideline for bone metabolism and disease on the risk of muscle and skin complaints in dialysis patients. Methods. As part of NECOSAD, a prospective multicentre study in the Netherlands, we included 1469 consecutive patients who started haemodialysis or peritoneal dialysis between 1997 and 2004. Muscle pain, cramps and itching (pruritus) and dry (xerosis) skin were repeatedly measured using the Kidney Disease Quality of Life-Short Form questionnaire. Odds ratios (OR) for the risk of complaints over time were calculated by generalized estimating equations (GEE) models. Results. Mean age was 59 {+/-} 15 years, 61% of the patients were male and 63% were on haemodialysis. At baseline >65% of the patients had muscle and skin complaints. Compared with patients who met the target, the risk of muscle pain was increased in patients with hyperphosphataemia [OR: 1.2; 95% confidence interval (CI): 1.1-1.5] iPTH concentrations below the target range were associated with lower risk of cramps (OR 0.8, 95%CI: 0.6-0.9). The risk of pruritus was increased in patients with severely elevated plasma calcium (OR 1.4; 95%CI: 1.1-1.7), phosphorus (OR 1.4; 95%CI: 1.1-1.7) and Ca x P product levels (OR 1.6; 95%CI: 1.3-2.0). Finally, increased plasma calcium concentrations were associated with an elevated risk of xerosis (OR 1.4; 95%CI: 1.1-1.9). Conclusions. Disturbed mineral metabolism according to the K/DOQI guideline is associated with more muscle and skin complaints in dialysis patients. These findings emphasize the importance of keeping mineral metabolism in dialysis patients in tight control
Nurmohamed S, Weenink A, Moeniralam H, Visser C, Bemelman F. Hyperammonemia in Generalized Mycobacterium genavense Infection after Renal Transplantation. American Journal of Transplantation 2007; 7(3):722-723.
Abstract: After solid organ transplantation, patients are susceptible to infection caused by uncommon pathogens due the immunosuppressive drug therapy. Here, we report the first case of disseminated Mycobacterium genavense infection in a HIV seronegative renal transplant patient. The most striking clinical feature was a decreased consciousness. Blood results revealed hyperammonemia with otherwise normal liver function. Occurrence of hyperammonemia and massive M. genavense infection has not been reported before
Pasterkamp G, Hellings WE, de Kleijn D, de Vries JP, Seldenrijk CA, de Bruin P, Velema E, Moll FL. Abstract 3578: Local Atherosclerotic Plaques Hide Information That Is Predictive For The Occurrence Of Adverse Cardiovascular Events And Will Help To Identify The Vulnerable Patient: A Prospective Cohort Study In 667 Patients. Circulation 2007; 116(16 suppl):II-810.
Peeters MY, Kuiper H, Greijdanus B, van der Naalt J, Knibbe CA, Uges DR. Gas chromatography-mass spectrometric assay for propofol in cerebrospinal fluid of traumatic brain patients. Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences 2007; 852(1-2):635-639.
Abstract: A sensitive gas chromatography-mass spectrometry method for measuring propofol in cerebrospinal fluid is described, validated and applied to four patients after traumatic brain injury. The limit of quantitation was 2mug/L using a volume of 0.5mL. The inter- and intra-assay coefficients of variation were 5.9 and 5.1%, respectively. The assay covers the linear concentration range of 2-50mug/L, which is relevant in clinical pharmacokinetic studies when propofol is used in the Intensive Care Unit as a sedative agent or to lower the intracranial pressure
Peeters MYM. Don't be afraid! Population PK-PD modeling as the basis for individualized dosing in children and critically ill. Wageningen: Ponsen & Looijen B.V., 2007.
Peeters W, Hellings WE, de Kleijn DP, Moll FL, Schoneveld A, de Vries JP, Busser E, Pasterkamp G. Abstract 2995: Natural History Of Carotid Atherosclerotic Plaque Remodeling After Tia And Stroke. Circulation 2007; 116(16 suppl):II-670.
Petrov MS, van Santvoort HC, Besselink MG, Cirkel GA, Brink MA, Gooszen HG. Oral refeeding after onset of acute pancreatitis: a review of literature. American Journal of Gastroenterology 2007; 102(9):2079-2084.
Abstract: BACKGROUND: Oral refeeding in patients recovering from acute pancreatitis may cause pain relapse. Patients with pain relapse may be ill for prolonged periods, thereby consuming additional health care resources. We aimed to determine the incidence and risk factors of pain relapse on the basis of reviewing all studies on oral refeeding in acute pancreatitis. METHODS: Relevant literature cited in three electronic databases (Cochrane Central Register of Controlled Trials, EMBASE, and MEDLINE) as well as the abstracts of major gastroenterological meetings was reviewed. Outcome measures studied were the incidence of pain relapse and length of hospital stay. RESULTS: A total of three studies met the inclusion criteria. Sixty of 274 patients (21.9%) experienced pain relapse during the course of acute pancreatitis. In 47 of 60 (78.3%) patients pain relapse occurred within 48 h after commencement of oral refeeding. Two studies showed a significantly higher Balthazar's CT score on hospital admission in patients with pain relapse, whereas all three studies found no difference in the severity scores between patients with and without pain relapse. All three studies found a significant increase in the length of hospital stay in patients with pain relapse. CONCLUSIONS: The incidence of pain relapse after oral refeeding in acute pancreatitis is relatively high. Thereby, the quest for new therapeutical modalities that can prevent pain relapse is of current importance
Planken RN. Hemodialysis vascular access imaging : Duplex ultrasound and contrast-enhanced magnetic resonance angiography. Maastricht: Datawyse, Universitaire Pers Maastricht, 2007.
Ponfoort E, de Vries JPPM, Hissink R, Moll FL. Debulking procedures for long occlusion of the SFA. In: Thompson MM, Morgan R, Matsumura J, Sapoval M, Loftus I, editors. Endovascular Intervention for Vascular Disease : Principles and Practice. Informa Healthcare, 2007.
Post MC, Budts WHL, Westerman CJJ. Cardiac and pulmonary Right-to-Left Shunts and Migraine. In: Clarke LB, editor. Migraine Disorders Research Trends. Nova Science Publishers, 2007.
Post MC, Luermans JG, Plokker HW, Budts W. Patent foramen ovale and migraine. Catheterization & Cardiovascular Interventions 2007; 69(1):9-14.
Abstract: Migraine is a common neurological disorder with a great impact on the quality of life and social activities. The patent foramen ovale (PFO) is an intra-atrial right-to-left shunt with a prevalence of 25% in the general population. An increased prevalence is found in patients with migraine, especially in migraine with aura. Percutaneous PFO closure might decrease the prevalence of migraine. However, most of these observational studies were retrospective without a randomized design and the results need to be interpreted with caution. In this review we describe the association between PFO and migraine and the different pathophysiological hypotheses, which have been proposed to explain this relationship. (c) 2006 Wiley-Liss, Inc
Post MC, Grutters JC, Verzijlbergen JF, Biesma DH. PET Scintigraphy of Etoposide-Induced Pulmonary Toxicity. Clinical Nuclear Medicine 2007; 32(9):683-684.
Abstract: A patient with chronic myelomonocytic leukemia developed drug-induced pulmonary toxicity after using low dose oral etoposide. Because etoposide-induced pulmonary toxicity is an uncommon but serious adverse event, clinicians must be vigilant about the possibility of it, so that the optimal treatment can start as soon as possible. This report demonstrates that PET scintigraphy might be a helpful tool in the early diagnosis of drug-induced pulmonary toxicity
Post S, Smits A, Sluijter J, Hoefer I, Snijder R, Mager J, Westermann C, Pasterkamp G, Doevendans P, Goumans MJ. A disturbed CXCR4/CD26 balance in endoglin deficient mononuclear cells results in impaired homing. VII International HHT scientific conference, Capri, Italy, 25-28 april 2007; Hematology Meeting Reports:22.
Ricci A, Graziano P, Bronzetti E, Saltini C, Sciacchitano S, Cherubini E, Renzoni E, du Bois RM, Grutters JC, Mariotta S. Increased pulmonary neurotrophin protein expression in idiopathic interstitial pneumonias. Sarcoidosis Vasculitis & Diffuse Lung Diseases 2007; 24(1):13-23.
Abstract: BACKGROUND AND AIM OF THE STUDY: Idiopathic interstitial pneumoniae (IIPs) are characterized by fibroblast proliferation, extracellular matrix deposition and progressive lung function impairment. Because effective therapeutic strategies still remain limited, research has been directed toward the identification of novel targets for additional therapeutic options. The neurotrophins (NTs) nerve growth factor (NGF), brain derived neurotrophic factor (BDNF) and NT-3, beside their importance in nervous, endocrine and immune system activities, participate in chronic inflammatory disorders and in repair processes. METHODS: We have investigated NT and high and low affinity NT receptor expression in IIPs using immunoblots and immunohistochemistry. Fourteen idiopatic pulmonary fibrosis/usual interstitial pneumoniae (IPF/UIP), eight non specific pneumoniae (NSIP) and eight respiratory bronchiolitis-associated interstitial lung disease (RB-ILD) were analyzed. RESULTS: Immunoblots revealed that NT and high affinity NT receptor proteins were more abundantly expressed in IPF/UIP than NSIP and RB-ILD patients. In RB-ILD, a faint expression of NT-3 and NT receptors were detected. NT and NT receptor immunostaining was detected in interstitial cells from IPF/UIP, NSIP and RB-ILD patients by immunohistochemistry. Fibroblastic foci in IPF/UIP strongly stained for BDNF and its high affinity receptor TrkB and in lesser amount for NGF, NT-3 and their respective high affinity receptors TrkA and TrkC. Furthermore, in fibroblast culture derived from IPF/UIP patients, the proliferation rate of primary culture and clones derived from primary lines was stimulated by BDNF but down regulated by NT-3. In contrast, NGF did not influence IPF/UIP fibroblasts proliferation. CONCLUSIONS: Our data suggest that that NTs may exert differential activities on lung fibroblasts and may be considered as potential regulatory molecules influencing fibroblast behavior in IPF/UIP patients. Therefore, NTs may play a role in IIPs patho-physiology representing novel potential therapeutic targets
Rijkers GT. Lactobacillen en de natuurlijke weerstand in de darm. Yakult Live 2007; 6(2):3-5.
Rijkers GT. De darmbarrière beschermt tegen infecties. Voeding en Visie 2007; 20(1):7-9.
Rijkers GT. Probiotica bij antibioticagebruikt. Schijnwerpers op . . . Campina Institute voor Zuivel en Gezondheid 2007; 11.
Rijkers GT. Het immuunsysteem en vaccinatie. In: Visser LG, editor. Praktische vaccinatievraagstukken. Alphen aan den Rijn: Van Zuiden Communications, 2007: 9-21.
Rijkers GT. Probiotica en de Hygienehypothese. Probiotica Nieuwsbrief 2007; 7:7-8.
Rijneveld AW, Koene HR, Kersten MJ. Maligne lymfomen bij patiënten met immuundeficiëntie ten gevolge van een hiv-infectie. Nederlands Tijdschrift voor Hematologie 2007; 6(4):204-209.
Rijneveld AW, Koene HR, Kersten MJ. Maligne lymfomen bij patiënten met hiv-infectie. Tijdschrift voor Infectieziekten 2007; 2(6):202-208.
Rijneveld AW, Koene HR, Kersten MJ. HIV gerelateerde lymfomen. Nederlands Tijdschrift voor Infectieziekten 2007.
Rops MJ, Maas KW, Schramel FM, Verzijlbergen FJ. The prognostic value of the standarized uptake value (SUV) of FDG-PET in patients with stage I and II non small cell lung cancer (NSCLC) treated by radical surgery. Journal of Thoracic Oncology 2007; 8(s4):s788.
Schaepkens FFJM, van der Heiden M. Zorgsector. Leidraad voor de AA 2007;(54):B.10.3-01-B.10.3-86.
Scheffer BRCH, Stolk MFJ, Seldenrijk CA, de Bruin PC, Timmer R, Weusten BLAM. EUS-Guided trucut biopsy versus EUS-guided fine needle aspiration; an evaluation of 67 patients with mediastinal lesions. Voorjaarsvergadering Ned Ver voor Gastroenterologie 2007.
Scheffer RC, Wiezer RJ, Timmer R. Recurrent Left-sided Colon Volvulus Leading to Mediastinal Shift. Clinical Gastroenterology & Hepatology 2007; 5(7):A34.
Scheffer RCH, Stolk MFJ, Seldenrijk CA, de Bruin PC, Timmer R, Weusten BLAM. EUS-Guided trucut biopsy versus EUS-guided fine needle aspiration; an evaluation of 67 patients with mediastinal lesions. DDW/AGA Washington 2007.
Schepens MA. Re: "treatment of a ruptured thoracoabdominal aneurysm with a stent-graft covering the celiac axis". Journal of Endovascular Therapy 2007; 14(2):268-269.
Schepens MA, Kelder JC, Morshuis WJ, Heijmen RH, van Dongen EP, ter Beek HT. Long-term follow-up after thoracoabdominal aortic aneurysm repair. Annals of Thoracic Surgery 2007; 83(2):S851-S855.
Abstract: BACKGROUND: Early mortality and morbidity after thoracoabdominal aortic aneurysm (TAAA) repair has been analyzed extensively; however, very few studies have examined the risk factors for late death. METHODS: We analyzed 500 consecutive TAAA repairs performed at St. Antonius Hospital between 1981 and March 30, 2006. Survival and freedom from aortic reoperation were calculated using the Kaplan-Meier method, and the effects of preoperative, intraoperative, and postoperative risk factors were evaluated using Cox proportional hazard analysis. Survival was compared with a Dutch population matched for age, sex, and date of operation. RESULTS: Patient survival with 95% confidence intervals (CI) was 83% (80% to 86%), 63% (58% to 67%), 34% (29% to 40%), 16% (9% to 20%), and 6% (2% to 11%) after 1, 5, 10, 15, and 20 years, respectively, compared with 100%, 99%, 85%, 36%, and 15% for the matched Dutch population. Hazard analysis showed an early phase of high hazard falling to low levels 9 months postoperatively and a late phase in which the hazard of death gradually increased. Incremental risk factors for late death were depressed left ventricular function (p < 0.001), increased age (p < 0.001), urgency (p = 0.007), postoperative dialysis (p < 0.001), and postoperative neurologic deficit (p = 0.016). Freedom from reoperation on the aorta with 95% CI was 98% (97% to 99%), 92% (89% to 94%), 86% (82% to 90%), 83% (78% to 87%), and 83% (78% to 87%) after 1, 5, 10, 15, and 20 years, respectively. CONCLUSIONS: Survival remains suboptimal, especially in the early years after TAAA repair, compared with a matched population. Avoidance of postoperative problems such as dialysis and neurologic deficits and performing elective surgery on relative young patients with unimpaired ventricular function will increase the likelihood of late survival
Schepens MAAM. Aortic arch replacement: the conventional 'elephant trunk' technique. Multimedia Manual of Cardiothoracic Surgery : MMCTS 2007;(January 2).
Schipper JA. Give Synagis via home care: a reply. Pediatrics 2007; 119(6):1258-1259.
Schippers H, Heidema J, Schipper H, de Koning-Tijssen M, de Vries L, Aicardi J. Neonatal presentation of alternating hemiplegia of childhood. European journal of paediatric neurology 2007; 11(suppl 1):55.
Schippers HM, Heidema J, Schipper JA, de Koning-Tijssen MAJ, Laan LL, de Vries LS, Aicardi J. Neonatal presentation of alternating hemiplegia of chilhood. 7th Congress of pediatric neurology society, Kusadasa, Turkey, 26-29 sept 2007.
Schoenmakers MC, van Boven WJ, van den Bosch J, van Swieten HA. Comparison of on-pump or off-pump coronary artery revascularization with lung resection. Annals of Thoracic Surgery 2007; 84(2):504-509.
Abstract: BACKGROUND: The simultaneous occurrence of coronary artery disease and lung cancer is rare. The best surgical treatment strategy remains controversial: performing a combined procedure with or without the use of extracorporeal circulation (ECC). The aim of this study was to compare the surgical procedure, postoperative complications, and survival of combined surgery with the use of ECC to combined surgery without ECC. METHODS: Forty-three patients underwent a combined procedure between 1994 and 2005. Twenty-eight patients (25 male and 3 female; mean age, 66 years; range, 54 to 76 years) underwent coronary artery (CA) revascularization with ECC after the lung resection was carried out (on-pump). Fifteen patients (14 male and 1 female; mean age, 71 years; range, 50 to 79 years) had first CA revascularization without ECC followed by lung resection (off-pump). Survival was estimated by the Kaplan-Meier method and analyzed using the log-rank test and the Cox proportional hazard regression model. RESULTS: Postoperative complications and hospital survival were not significantly different between groups. However, in the on-pump group late survival was significantly better. Late survival was significantly longer in patients without recurrent vessel disease and with stage I lung cancer. CONCLUSIONS: These results show no significant difference in using an on-pump or off-pump technique to perform a combined cardiac and lung surgery in relation to postoperative complications and hospital survival. However, our data show a significantly longer late survival period in the on-pump group. Because the off-pump patients were older and had more advanced lung malignancy, the off-pump technique should be continued and evaluated
Schotman M, Giesbers AAGM, Vijverberg PLM. Heeft de perineale prostatectomie nog toekomst? Nederlands Tijdschrift voor Oncologie 2007; 4:194-197.
Schölzel BE, Tahapary GJM, Dewilde W, Boersma LVA. A young patient with excessive tachycardia. Netherlands Heart Journal 2007; 16(1):26, 35.
Schramel FMNH. Wat is de waarde van chemotherapie bij patienten met een stadium IV NSCLC die bij presentatie al hersenmetastasen hebben? Oncologie Vademecum 2007; 4(2).
Schutgens RE, Haas FJ, Agterof MJ, Vos M, Biesma DH. The role of fibrin monomers in optimizing the diagnostic work-up of deep vein thrombosis. Thrombosis & Haemostasis 2007; 97(5):807-813.
Abstract: Despite the use of a clinical score and D-dimers to exclude deep vein thrombosis (DVT), the majority of patients still need repeated ultrasound (US). The aim of the study was to investigate whether fibrin monomers (FMs), as markers of thrombin generation, have additional value in the diagnosis of DVT. This is a posthoc analysis of 464 outpatients, participants in a management study using D-dimers (Tina-Quant((R))) and a clinical score in the exclusion of DVT. Two new FM assays (Auto LIA-FM((R)) and IATRO SF((R)), Japan) were performed. Overall sensitivity, negative predictive value (NPV) and specificity of the D-dimer test were 98%, 98% and 42%. The optimal cut-off point for the Auto LIA-FM test was </=3 mug/ml with values of 88%, 88% and 59%, respectively. The IATRO SF test had an optimal cut-off point of </=2 mug/ml with values of 92%, 81 and 22%, respectively. The NPV of a non-high clinical score and a normal D-dimer (n = 97) was 100%. In patients with a high clinical score (n = 160), the NPV of the D-dimer was 88%. In these patients, a single US combined with a normal D-dimer or FM test had an equal NPV as serial US (100 versus 98%, respectively) and lead to a reduction in the need for US by 36-53%, respectively. In patients with abnormal D-dimer concentrations (n = 343), a normal US combined with a normal Auto LIA-FM test had a NPV of 97%, which was also true for serial US. This could lead to a reduction in the need for US by 45%. The present studied FMs are inferior to the Tina-Quant D-dimer test when used as primary screening tool to exclude DVT. Adding these FMs to patients with a normal Tina-Quant D-dimer has no benefit. In patients with a high pretest clinical probability score, a single US in combination with a normal D-dimer or FM test might be as safe as serial US. In patients with abnormal D-dimer concentrations and a normal US, a normal FM test might be able to replace the second US
Sijmons EA, Lankveld MA, Witteveen PO, Peeters PH, Koot VC, Schagen van Leeuwen JH. Compliance to clinical guidelines for early-stage epithelial ovarian cancer in relation to patient outcome. European Journal of Obstetrics, Gynecology, & Reproductive Biology 2007; 131(2):203-208.
Abstract: OBJECTIVES: To assess compliance to current surgical staging and adjuvant treatment guidelines for patients with early-stage epithelial ovarian carcinoma and its impact on overall survival. METHODS: Patients diagnosed between 1991 and 1997 with early-stage ovarian cancer were recruited from the Regional Cancer Registry of the central region in the Netherlands. Demographic data, tumour characteristics, surgical findings and therapeutic data were abstracted from medical records. Patients were classified into optimal and non-optimal surgical staging. Overall survival was estimated using Kaplan-Meier method. To adjust for age hazard ratios for overall survival were estimated with a Cox Proportional Hazards model. RESULTS: One hundred and twenty-five patients were included in the study, 41 of them (32.8%) were optimally staged. Guidelines for adjuvant radio- or chemotherapy were adequately followed in all 62 grade I patients and in 44 out of 59 grade II and III patients (74.6%). During 734.6 person-years of follow up 31 patients died. Five-year overall survival figures were 97.6% in the optimally staged group and 68.5% in the non-optimally staged group. Patients who were non-optimally staged, had a significant higher risk to die than those who were optimally staged (HR: 7.4; 95% CI: 1.7-32.2). In patients with a grade II and III tumours, complete surgical staging still had a significant influence on survival (HR: 3.8; 95% CI 1.7-8.3). In women with grade II or III tumours, adjuvant radio- or chemotherapy administered in accordance to the guidelines did not improve overall survival regardless whether they were optimally staged or not. CONCLUSION: Incomplete staging in early-stage ovarian cancer leads to gross mis-classification in grade II and III tumours and to a lesser extent in grade I tumours. This leads to undertreatment in both surgical and adjuvant therapy. Subsequently unnecessary deaths may occur. More effort must be put in identifying obstacles interfering with compliance of guidelines
Sijssens KM, Rijkers GT, Rothova A, Stilma JS, Schellekens PA, de Boer JH. Cytokines, chemokines and soluble adhesion molecules in aqueous humor of children with uveitis. Experimental eye research 2007; 85(4):443-449.
Abstract: Uveitis in childhood is a visual threatening disease with a complication rate of more than 75%. Despite extensive research, the etiology of uveitis is still unclear although the general opinion is now that uveitis is a T-cell mediated disease. The purpose of this study was to investigate the profile of cytokines, chemotactic cytokines (chemokines) and soluble adhesion molecules in the aqueous humor (AqH) of children with uveitis in order to identify the factors that control the immune response in the eye. In this clinical laboratory investigation we analyzed, with a multiplex immunoassay, 16 immune mediators in the AqH of 25 children with uveitis and 6 children without uveitis. Increased levels of interleukin-2 (IL-2), IL-6, IL-10, IL-13, IL-18, interferon-gamma, tumor necrosis factor-alpha, soluble intercellular adhesion molecule-1, RANTES, IL-8 and interferon-inducible 10-kDa protein were found in the AqH of children with uveitis compared with controls. No significant differences were found for IL-1 beta, IL-4, IL-12 p-70, soluble vascular cell adhesion molecule 1 and Eotaxin. Lower levels of IL-10 and IL-8 were found in quiet stage uveitis (surgical) samples compared with active uveitis (diagnostic) samples and in samples of patients treated with methotrexate (MTX) compared with samples of patients not treated with MTX. Lower levels of IL-10 were as well found in samples taken during the first 3 months after the diagnosis of uveitis than samples taken later during the disease process. No significant differences were found between patients treated with or without topical or systemic (perioperative and long term) corticosteroids. In conclusion, in children with uveitis, multiple intraocular cytokines, chemokines and soluble adhesion molecules are increased in the AqH regardless of active or inactive inflammation. Whether the IL-8 and IL-10 levels in AqH of children with uveitis are correlated with uveitis activity, early or late phase of the course of the disease and systemic treatment with MTX needs further investigation in a bigger study population
Slee PH, van der Waal RI, Schagen van Leeuwen JH, Tupker RA, Timmer R, Seldenrijk CA, van Steensel MA. Paraneoplastic hypertrichosis lanuginosa acquisita: uncommon or overlooked? British Journal of Dermatology 2007; 157(6):1087-1092.
Abstract: Acquired hypertrichosis lanugo-type or hypertrichosis lanuginosa acquisita (HLA) is often associated with metabolic and endocrine disorders and use of certain drugs. The occurrence of HLA with malignancy was first noted in 1865, and it has since been described in 56 patients as a paraneoplastic syndrome both in women and in men. Sometimes HLA occurs concurrent with acanthosis nigricans, papillary hypertrophy of the tongue, and glossitis. The predominance of female cases is striking. Malignancy-associated HLA seems to occur especially in the age group 40-70 years. In women with HLA the most frequent malignancy is colorectal cancer, followed in order by lung cancer and breast cancer; in men lung cancer is the malignancy most frequently associated with HLA, followed by colorectal cancer. In 3 years we saw 10 patients with HLA, in whom the malignancy was usually metastasized. Only one patient had local disease; after removal of the primary tumour it took 2 years before the lanugo hair recurred. The aetiology of the syndrome is not clear: no specific hormonal or biochemical abnormalities have been identified as yet. The difference between hirsutism and lanugo-type hypertrichosis is discussed. It is stressed that the appearance of lanugo-type hypertrichosis in body areas previously perceived by patients as 'hairless' is highly indicative of internal malignancy
Slee PHThJ, Plokker HWM. Diagnose in beeld (349) Een vrouw met opvliegers. Nederlands Tijdschrift voor Geneeskunde 2007; 151(45):2502.
Slee PHThJ, Luermans JGLM, de Jong PC, van den Brand MWM, Vijverberg PLM. Behandeling van patienten met een gemetastaseerd testiscarcinoom in een groot niet-academisch ziekenhuis: vergelijking met literatuurgegevens. Nederlands Tijdschrift voor Oncologie 2007; 4(8):369-375.
Sluman MA, de Weerdt O, Tersmette M, Biesma DH. A rare fulminant infection in a patient with acute leukemia. 19e Internistendagen : abstractboek :25, 26 & 27 april 2007 MECC Maastricht 2007;69-70.
Sluman MA, Biesma DH, Geers ABM. A dangerous hobby : fish-tank granuloma. 19e Internistendagen : abstractboek :25, 26 & 27 april 2007 MECC Maastricht 2007;105-106.
Smeets L, Huijbregts HJ, Ho GH, de Vries JP, Moll FL. Clinical outcome after re-occlusion of initially successful remote endarterectomy of the superficial femoral artery. Journal of Cardiovascular Surgery 2007; 48(3):309-314.
Abstract: AIM:The clinical consequences of re-occlusion after initially successful arterial revascularization procedures might be as important as patency when it comes to procedure selection. This study evaluates the clinical consequences of re-occlusion after initially successful remote superficial femoral artery endarterectomy (RSFAE), in particular the recurrence and severity of symptoms and the need for re-intervention or amputation. METHODS: A total of 239 successful RSFAEs were performed with a mean endarterectomized segment of 30 cm (10 to 45 cm) between March 1994 and December 2003 in 214 patients (144 males, 163 procedures) with a median age of 63 years (39 to 89 years). Indications for operation were Rutherford category 3 in 174 procedures (73%), Rutherford category 4 in 27 procedures (11%), and Rutherford category 5 in 38 procedures (16%). The incidence and time interval of re-occlusion with the presenting symptoms were recorded as well as the therapeutic consequences. RESULTS: A total of 79 (33%) re-occlusions occurred (40 males, 41 procedures; 34 females, 38 procedures). Eighty percent of patients still had improved or unchanged symptoms following re-occlusion compared to the initial indication for operation, 18% had become worse and 2% were unknown. The mean time between RSFAE and re-occlusion was 17 months (1 day to 88 months). A total of 36 re-interventions were performed: 7 percutaneous recanalisations (one followed by thrombolysis), 5 percutaneous thrombolyses, 1 thrombectomy, 21 venous and 2 prosthetic femoropopliteal bypasses. A further three venous bypasses were planned. Five (14%) of these re-interventions were acute with an overall median time interval between re-occlusion and re-intervention of 41 days (0 to 68 months). Two below-knee amputations were performed: one the same day of re-occlusion, 44 months after RSFAE and one 11 days after re-occlusion, 30 days after RSFAE. CONCLUSION: The clinical consequences of re-occlusion after remote endarterectomy for long occlusive disease of the superfricial femoral artery, from a mixed patient population with 27% ischemic rest pain and gangrene, were mild with 31 elective and only five acute re-interventions and two below-knee amputations
Smit CA, Slim EJ. Heart conduction problems in a tetraplegic patient caused by a single therapeutic dosage of Baclofen. Spinal Cord 2007; 46(4):317-318.
Abstract: Study design:Case report.Objective:To examine the unusual and unknown, severe side effect of a therapeutic dose of oral Baclofen on cardiac function.Setting:Spinal Cord Unit, Rehabilitation Centre Amsterdam, Amsterdam, The Netherlands.Methods:Review of relevant literature.Results:A 53-year-old patient with an incomplete C2 tetrapareses (ASIA B) developed severe and painful muscle spasms together with respiratory failure and autonomic dysreflexia. Spasmolytic treatment was started. After the first admission of 5 mg of oral Baclofen, he collapsed in bed with extreme bradycardia, hypotension, hyperventilation and decreased oxygen saturation. A second dosage of 5 mg Baclofen resulted in the same complications. After implantation of a pacemaker, restarting oral Baclofen induced a pacemaker rhythm with episode of hypotension and respiratory failure and also a delirium. Intrathecal Baclofen also resulted in a pacemaker rhythm with hypotension and a decreased cardiac output. To our knowledge, this is the first time a severe heart conduction problem was induced in a spinal cord injury patient after a single therapeutic dose of Baclofen.Conclusion:In this case therapeutic oral Baclofen has caused serious cardiac conduction problems.Spinal Cord advance online publication, 9 October 2007; doi:10.1038/sj.sc.3102123
Smit LA, Bongers SI, Ruven HJ, Rijkers GT, Wouters IM, Heederik D, Omland O, Sigsgaard T. Atopy and new-onset asthma in young Danish farmers and CD14, TLR2, and TLR4 genetic polymorphisms: a nested case-control study. Clinical & Experimental Allergy 2007; 37(11):1602-1608.
Abstract: Background Evidence exists that exposure to high levels of microbial agents such as endotoxin in the farm environment decreases the risk of atopic sensitization. Genetic variation in innate immunity genes may modulate the response to microbial agents and thus influence susceptibility to asthma and atopy. Objective To study potential associations between single nucleotide polymorphisms (SNPs) in CD14, Toll-like receptor 2 (TLR2), and TLR4 genes, and atopy and new-onset asthma in young farmers. Methods A nested case-control study was conducted within a cohort of 1901 young Danish farmers. We genotyped 100 new-onset asthma cases and 88 control subjects for three CD14 SNPs, three TLR2 SNPs, and two TLR4 SNPs. Atopy at baseline (defined as a positive skin prick test to one or more common inhalant allergens) was found in 17 asthma cases (17.0%) and in 17 controls (19.3%). Results The CD14/-260T allele was significantly associated with less atopy [odds ratio (OR) 0.39; 95% confidence interval (CI) 0.21-0.72, additive genetic model], whereas the CD14/-651T allele was positively associated with atopy (OR 2.53; 95% CI 1.33-4.80). Similar results were obtained by haplotype analysis. Stratified analysis by farm childhood showed stronger effects of both CD14 SNPs on atopy among farmers who were born and raised on a farm, although no significant interaction was found. No associations between CD14, TLR2, or TLR4 genotypes and new-onset asthma were found. Conclusion The CD14/-260 and CD14/-651 promoter polymorphisms are associated with atopy prevalence among young adults exposed to farm environments
Smits AM, Post S, Sluijter JPG, Hoefer IE, Snijder R, Mager J, Westermann C, Pasterkamp G, Doevendans PA, Goumans MJ. The impaired homing of mononuclear cells to ischemic regions in HHT-1 patients is due to a disturbed balance in CXCR4 and CD26 expression. European Heart Journal 2007;(Suppl):797.
Snijder RJ. Porto-pulmonary hypertension. Yearbook pulmonary hypertension. 2007: 59-71.
Spagnolo P, Sato H, Grutters JC, Renzoni EA, Marshall SE, Ruven HJ, Wells AU, Tzouvelekis A, van Moorsel CH, van den Bosch JM, du Bois RM, Welsh KI. Analysis of BTNL2 genetic polymorphisms in British and Dutch patients with sarcoidosis. Tissue Antigens 2007; 70(3):219-227.
Abstract: Sarcoidosis is a heterogeneous disorder, both phenotypically and genetically. Two independent studies have recently shown that a functional polymorphism within butyrophilin-like 2 (BTNL2) gene predisposes to sarcoidosis independently of the human leukocyte antigen (HLA)-DRB1 alleles. However, in both studies, data analysis was not stratified by Lofgren's syndrome, a clinically and genetically distinct sarcoidosis subset. BTNL2, potentially encoding an immune coreceptor, is adjacent and in linkage disequilibrium (LD) with HLA-DRB1. We investigated six BTNL2 variants, including the functional rs2076530 (G > A), as well as HLA-DRB1 alleles, by sequence-specific primers-polymerase chain reaction, in 288 patients and 446 controls from two European countries. In the patient group as a whole, the HLA-DRB1*14 [odds ratio (OR) = 3.1, P(c) = 0.0003], DRB1*12 (OR = 2.5, P(c) = 0.003), and BTNL2 rs2076530 A allele (OR = 1.49, P(c) = 0.002) were all associated with disease susceptibility. However, after exclusion of patients presenting with Lofgren's syndrome and after adjusting for HLA-DRB1 alleles, the association between BTNL2 rs2076530 A and disease disappeared (P = 0.23). By contrast, both HLA-DRB1*14 and DRB1*12 remained strongly significant (OR = 3.60, P < 0.0001 and OR = 3.03, P = 0.003, respectively). BTNL2 haplotype 4, tagged by the rs2076530 G allele, also remained associated with non-Lofgren sarcoidosis after adjusting for HLA-DRB1 alleles (OR 0.37, P = 0.016). In summary, HLA-DRB1*14, DRB1*12, and BTNL2 haplotype 4 - but not rs2076530 A - are associated with non-Lofgren sarcoidosis. However, the tight LD across the HLA complex makes it difficult to identify the precise location of the susceptibility locus/i. Larger sample sets from different ethnic groups, finer mapping, and more robust LD analyses across the HLA region are needed
Spijker A. Chronische nierinsufficiëntie. Dieetbehandelingsrichtlijn. Elsevier/ De Tijdstroom, 2007: 1-32.
Stadhouders PH, Kuiper JJ, van Buuren HR, de Man RA. Spontane bacteriele peritonitis, een ernstige complicatie van levercirrose. Nederlands Tijdschrift voor Geneeskunde 2007; 151(9):509-513.
Abstract: Three patients with hepatic cirrhosis and ascites, a 65-year-old man, a 17-year-old woman and a 49-year-old man, were admitted to hospital for progressive drowsiness, increased ascites, and melaena, respectively. An elevated number of polymorphonuclear leukocytes was found in the ascites. The three patients became more and more seriously ill. On the basis of the laboratory findings, a diagnosis of 'spontaneous bacterial peritonitis' was made. The patients recovered after administration of antibiotics. The signs and symptoms of spontaneous bacterial peritonitis can range from subtle, renal dysfunction or an altered mental state to the signs ofan acute abdomen. The common signs of infection such as fever and an elevated leukocyte count are present in only 50% of the patients. Gram-negative bacteria are most frequently isolated from cultures of the ascites fluid. The 1-year mortality is still 50-70% and is partly a result of the underlying liver disease. Prophylactic oral administration of a quinolone decreases the risk of spontaneous bacterial peritonitis in patients with gastrointestinal haemorrhage and in patients with a prior episode of spontaneous bacterial peritonitis. Long-term prophylaxis has been associated with the development of infections with quinolone-resistant microorganisms
Stads S, Venneman NG, Scheffer RC, Samsom M, van Erpecum KJ. Evaluation of gallbladder motility: comparison of two-dimensional and three-dimensional ultrasonography. Annals of hepatology 2007; 6(3):164-169.
Abstract: Since impaired gallbladder emptying contributes to gallstone formation, the evaluation of gallbladder motility requires accurate methodology. Recently developed 3-dimensional ultrasonography may take into account various gallbladder shapes more accurately than conventional 2-dimensional ultrasonography. Therefore, volumes of water-filled balloons of various sizes were determined in vitro by 2-dimensional ultrasonography with the sum of cylinders method and by 3-dimensional ultrasonography. Also, in 15 gallstone patients and 6 healthy volunteers, fasting gallbladder volumes and postprandial motility were determined by both methods. Volumes of water-filled balloons as measured by both methods correlated strongly with true volumes (R= 0.93 for 2-dimensional and R = 0.98 for 3- dimensional ultrasonography). Gallbladder volumes measured by both methods were also correlated (R = 0.66, P <0.001). In gallstone patients, 3-dimensional ultrasonography yielded smaller gallbladder volumes than 2-dimensional ultrasonography (P = 0.007), but not in healthy subjects. With both methods, gallstone patients exhibited decreased postprandial gallbladder motility compared to healthy subjects. In conclusion, gallbladder volume measurements by 3-dimensional and 2-dimensional ultrasonography are strongly correlated.Nevertheless, in gallstone patients, gallbladder volumes by 3-dimensional ultrasonography tend to be smaller than by 2-dimensional ultrasonography, possibly due to interference of gallstones with the volume measurement
Stegggerda R, Slee PHThJ, te Raa GD, ter Borg EJ. Are the effects of local treatment with glucocorticosteroids only local? 19e Internistendagen : abstractboek :25, 26 & 27 april 2007 MECC Maastricht 2007;19-20.
Steinbusch PJ, Oostenbrink JB, Zuurbier JJ, Schaepkens FJ. The risk of upcoding in casemix systems : a comparative study. Health Policy 2007; 81(2-3):289-299.
Abstract: With the introduction of a diagnosis related group (DRG) classification system in the Netherlands in 2005 it has become relevant to investigate the risk of upcoding. The problem of upcoding in the US casemix system is substantial. In 2004, the US Centres for Medicare and Medicaid estimated that the total number of improper Medicare payments for the Prospective Payment system for acute inpatient care (both short term and long term) amounted to US$ 4.8 billion (5.2%). By comparing the casemix systems in the US, Australian and Dutch healthcare systems, this article illustrates why certain casemix systems are more open to the risk of upcoding than other systems. This study identifies various market, control and casemix characteristics determining the weaknesses of a casemix reimbursement system to upcoding. It can be concluded that fewer opportunities for upcoding occur in casemix systems that do not allow for-profit ownership and in which the coder's salary does not depend on the outcome of the classification process. In addition, casemix systems in which the first point in time of registration is at the beginning of the care process and in which there are a limited number of occasions to alter the registration are less vulnerable to the risk of upcoding. Finally, the risk of upcoding is smaller in casemix systems that use classification criteria that are medically meaningful and aligned with clinical practice. Comparing the US, Australian and Dutch systems the following conclusions can be drawn. Given the combined occurrences of for-profit hospitals and the use of the secondary diagnosis criterion to classify DRGs, the US casemix system tends to be more open to upcoding than the Australian system. The strength of the Dutch system is related to the detailed classification scheme, using medically meaningful classification criteria. Nevertheless, the detailed classification scheme also causes a weakness, because of its increased complexity compared with the US and Australian system. It is recommended that researchers and policy makers carefully consider all relevant market, control and casemix characteristics when developing and restructuring casemix reimbursement systems
Stettler C, Wandel S, Allemann S, Kastrati A, Morice MC, Schomig A, Pfisterer ME, Stone GW, Leon MB, de Lezo JS, Goy JJ, Park SJ, Sabate M, Suttorp MJ, Kelbaek H, Spaulding C, Menichelli M, Vermeersch P, Dirksen MT, Cervinka P, Petronio AS, Nordmann AJ, Diem P, Meier B, Zwahlen M, Reichenbach S, Trelle S, Windecker S, Juni P. Outcomes associated with drug-eluting and bare-metal stents: a collaborative network meta-analysis. Lancet 2007; 370(9591):937-948.
Abstract: BACKGROUND: Whether the two drug-eluting stents approved by the US Food and Drug Administration-a sirolimus-eluting stent and a paclitaxel-eluting stent-are associated with increased risks of death, myocardial infarction, or stent thrombosis compared with bare-metal stents is uncertain. Our aim was to compare the safety and effectiveness of these stents. METHODS: We searched relevant sources from inception to March, 2007, and contacted investigators and manufacturers to identify randomised controlled trials in patients with coronary artery disease that compared drug-eluting with bare-metal stents, or that compared sirolimus-eluting stents head-to-head with paclitaxel-eluting stents. Safety outcomes included mortality, myocardial infarction, and definite stent thrombosis; the effectiveness outcome was target lesion revascularisation. We included 38 trials (18,023 patients) with a follow-up of up to 4 years. Trialists and manufacturers provided additional data on clinical outcomes for 29 trials. We did a network meta-analysis with a mixed-treatment comparison method to combine direct within-trial comparisons between stents with indirect evidence from other trials while maintaining randomisation. FINDINGS: Mortality was similar in the three groups: hazard ratios (HR) were 1.00 (95% credibility interval 0.82-1.25) for sirolimus-eluting versus bare-metal stents, 1.03 (0.84-1.22) for paclitaxel-eluting versus bare-metal stents, and 0.96 (0.83-1.24) for sirolimus-eluting versus paclitaxel-eluting stents. Sirolimus-eluting stents were associated with the lowest risk of myocardial infarction (HR 0.81, 95% credibility interval 0.66-0.97, p=0.030 vs bare-metal stents; 0.83, 0.71-1.00, p=0.045 vs paclitaxel-eluting stents). There were no significant differences in the risk of definite stent thrombosis (0 days to 4 years). However, the risk of late definite stent thrombosis (>30 days) was increased with paclitaxel-eluting stents (HR 2.11, 95% credibility interval 1.19-4.23, p=0.017 vs bare-metal stents; 1.85, 1.02-3.85, p=0.041 vs sirolimus-eluting stents). The reduction in target lesion revascularisation seen with drug-eluting stents compared with bare-metal stents was more pronounced with sirolimus-eluting stents than with paclitaxel-eluting stents (0.70, 0.56-0.84; p=0.0021). INTERPRETATION: The risks of mortality associated with drug-eluting and bare-metal stents are similar. Sirolimus-eluting stents seem to be clinically better than bare-metal and paclitaxel-eluting stents
Surmont V, van Klaveren RJ, Goor C, Schramel F, Manegold C, Legrand C, van Schil P, van Meerbeeck JP. Lessons to learn from EORTC study 08981: a feasibility study of induction chemoradiotherapy followed by surgical resection for stage IIIB non-small cell lung cancer. Lung Cancer 2007; 55(1):95-99.
Abstract: The present EORTC phase II feasibility study in stage IIIB (T4-N3) NSCLC was conducted to investigate whether an induction regimen with concurrent chemoradiotherapy followed by surgery after restaging by re-mediastinoscopy and/or fluorodeoxyglucose-positron emisson tomography (FDG-PET) was feasible in a multicenter setting. Unfortunately, the study closed prematurely because of poor accrual. The combination of more stringent selection criteria, the incorrect prevailing view of Ethical Boards that a tri-modality approach is too toxic, competing studies in the participating centers and the fact that patients with N3 disease could only be enrolled if a re-mediastinoscopy could be performed, underlie the low accrual. Although this study illustrates that the conduct of a tri-modality study across Europe appeared to be difficult at that time, the number of centers with highly qualified and experienced specialists involved in this kind of multi-modality approaches is rapidly increasing. Future initiatives should, therefore, certainly be encouraged. Minimally invasive procedures such as EUS and EBUS should preferably be used for up-front mediastinal staging, mediastinoscopy with or without EUS should preferably be reserved for restaging, and especially right-sided pneumonectomies should be avoided. Though evident, the feasibility to complete this kind of studies within a reasonable time period is still a condition sine qua non
Suttorp MJ, Laarman GJ, PRISON III study investigators. A randomized comparison of sirolimus-eluting stent implantation with zotarolimus-eluting stent implantation for the treatment of total coronary occlusions: rationale and design of the PRImary Stenting of Occluded Native coronary arteries III (PRISON III) study. American Heart Journal 2007; 154(3):432-435.
Abstract: Primary intracoronary drug-eluting stent placement after the successful crossing of total coronary occlusions decreases restenosis rate at long-term follow-up compared with bare-metal stent implantation. The PRISON II trial was the first randomized study to show the safety and efficacy of sirolimus-eluting stents in patients with totally occluded native coronary arteries. The sirolimus-eluting stent is superior to the bare-metal stent in treating patients with total coronary occlusions, with significant reduction in angiographic binary in-stent and in-segment restenosis resulting in significantly reduced need for target lesion and target vessel revascularization. Whether sirolimus-eluting stents are superior to other drug-eluting stents in total coronary occlusions is unknown. In this prospective, randomized trial, sirolimus-eluting stent implantation will be compared with zotarolimus-eluting stent implantation for the treatment of total coronary occlusions. A total of 300 patients will be followed for up to 5 years with angiographic follow-up at 8 months. Quantitative coronary analysis will be performed by an independent core laboratory. The primary end point will be in-segment late luminal loss at 8 months angiographic follow-up
Swinkels BM, Scheffer RC, Tahapary GJ, Jaarsma W, Plokker HW, Mast EG, Boersma LV. Cardiac tamponade as the initial manifestation of systemic lupus erythematosus in a young female patient. Netherlands Heart Journal 2007; 15(2):71.
Swinkels BM, Boersma LV, Rensing BJ, Jaarsma W. Isolated left ventricular noncompaction in a patient presenting with a subacute myocardial infarction. Netherlands Heart Journal 2007; 15(3):109-111.
Abstract: Isolated left ventricular noncompaction is a rare cardiomyopathy that is often not recognised. So far, it is not well established how best to manage this abnormality. We describe a patient in whom the diagnosis of isolated left ventricular noncompaction was made after presentation with a subacute myocardial infarction. Because of nonsustained ventricular tachycardias during hospitalisation, which were inducible and deteriorated into ventricular fibrillation on electrophysiological examination after coronary artery bypass grafting, he received an implantable defibrillator. Whether the ventricular tachycardias were due to the myocardial infarction or to the noncompacted myocardium remains uncertain. (Neth Heart J 2007;15:109-11.)
te Raa GD, Rodenburg G, Slee PHThJ, Claessen AME, Tersmette M. Leptospirosis. 19e Internistendagen : abstractboek :25, 26 & 27 april 2007 MECC Maastricht 2007;96-97.
te Raa GD, Slee PH. Syndroom van Cushing: nieuwe ontwikkelingen in de diagnostiek en nieuwe behandelingen. Nederlands Tijdschrift voor Geneeskunde 2007; 151(5):332.
te Raa GD, van Dorp S, Slee PHThJ, van Ballegooie E. A practical algorithm for the analysis of hypoglycaemia in non-diabetic patients, illustrated with four patients. 19e Internistendagen : abstractboek :25, 26 & 27 april 2007 MECC Maastricht 2007;6-7.
te Raa GD, Biesma DH, Ribbert L, Snijder RJ. The successful treatment of massive pulmonary embolism during pregnancy. 19e Internistendagen : abstractboek :25, 26 & 27 april 2007 MECC Maastricht 2007;35.
te Riele WW, de Jong JR, Vogten JM, Wiezer R, Slee PHThJ, van Ramshorst B. Duurzaam gewichtsverlies 2 jaar na laparoscopische maagbandplaatsing wegens morbide obesitas. Nederlands Tijdschrift voor Geneeskunde 2007; 151(20):1130.
ten Berg JM, Slee PHThJ. Screening for Fabry's disease in patients with cardiomyopathy. Netherlands Heart Journal 2007; 18(7/8):278.
ten Broeke R, Deneer VHM, Vernooij PD, van den Bosch JMM, Folkerts G, Tjoeng MM. Het effect van bèta-agonisten en corticosteroïden op de cytokineproductie bij COPD-patiënten. PW Wetenschappelijk Platform 2007; 1(2):30-33.
ten Heuvel A, Schramel FM, Biesma DH. Fondaparinux in the management of recurrent venous thromboembolic events in a patient with active lung cancer. Thrombosis Research 2007; 120(4):635-637.
Tenthof van Noorden J, den Ouden H, Stolk MFJ, de Weerdt O, de Bruin PC. Imaging modalities in EATL. In: Mulder CJJ, editor. Atlas of double balloon endoscopy. Medconnect, 2007.
ter Borg EJ, Haanen HC, Seldenrijk CA. Relationship between histological subtypes and clinical characteristics at presentation and outcome in biopsy-proven temporal arteritis : identification of a relatively benign subgroup. Clinical Rheumatology 2007; 26(4):529-532.
Abstract: Temporal arteritis (TA) may offer major complications, whilst high dosage of prednisone may result in serious side effects. We tried to identify a subgroup of TA, which can be treated with a lower dosage of prednisone. Retrospectively, clinical and laboratory data were studied at presentation, as well as the outcome in 44 consecutive patients with biopsy-proven temporal arteritis. These data were related to three particular histological subgroups, (a) classical giant cell arteritis, (b) atypical arteritis, and (c) 'healed arteritis', defined according to Allsop and Gallagher (The American Journal of Surgical Pathology 5:317-332, 1981). At presentation in subgroup c, erythrocyte sedimentation rate was lower and the level of haemoglobin was higher than in the other two subgroups. During follow-up in the healed arteritis group, reactivation, recurrence, or early death were not observed, whilst prednisone dosage after 2 and 3 years was lower compared to subgroup b. Major complications (permanent blindness and cerebrovascular accident) were only observed in subgroups a and b. We believe that the healed arteritis subgroup represents a relatively benign subgroup with a mild clinical presentation and a good prognosis. Therefore, a much lower initial prednisone dosage (15 mg/day) is suggested for patients in subgroup c than in the other two subgroups (40-60 mg/day)
Tersmette M, Leusink JA. Infectieproblematiek. In: Hennis PJ, Leusink JA, editors. Anesthesiologie. Houten: Bohn Stafleu Van Loghum, 2007: 279-288.
Tiel-van Buul MMC, Lavalaye J, Keijsers RGM. Drie tevoren gezonde personen met een vermoeidheidsfractuur. Nederlands Tijdschrift voor Geneeskunde 2007; 151:1154-1155.
Timmer-de Mik L, van der Waal RIF, Canninga-van Dijk MR, Dikland WJ, Rodenburg CJ, Bruijnzeel-Koomen CAFM. Mucocutane manifestaties van amyloïdose. Nederlands Tijdschrift voor Geneeskunde 2007; 151(37):2032-2037.
Abstract: samenvatting
– Amyloïdose is de verzamelnaam voor een groep zeldzame stapelingsziekten waarbij onoplosbare amyloïde fibrileiwitten in weefsels en organen neerslaan. Bij deze aandoening worden frequent mucocutane afwijkingen gevonden.
– De verschillende soorten amyloïdose worden ingedeeld in een systemische en een niet-systemische groep. Systemische amyloïdose wordt gekenmerkt door amyloïddeposities in diverse organen.
– Bij de meest voorkomende vorm van systemische amyloïdose, namelijk die van het lichteketentype (AL), is de huid in 29-40% van de gevallen aangedaan. Soms vormen deze huidafwijkingen het eerste aanknopingspunt voor het ontdekken van systemische betrokkenheid.
– In de niet-systemische groep vinden we met name gelokaliseerde afwijkingen in de huid en de mucosa.
– De behandeling van de gelokaliseerde mucocutane afwijkingen bij amyloïdose richt zich op de afwijkingen zelf.
– Mucocutane afwijkingen als gevolg van een systemische amyloïdose kunnen verbeteren wanneer het mogelijk is de onderliggende aandoening succesvol te behandelen.Timmerman HM, Niers LE, Ridwan BU, Koning CJ, Mulder L, Akkermans LM, Rombouts FM, Rijkers GT. Design of a multispecies probiotic mixture to prevent infectious complications in critically ill patients. Clinical Nutrition 2007; 26(4):450-459.
Abstract: BACKGROUND & AIMS: Although the potential for probiotics is investigated in an increasing variety of diseases, there is little or no consensus regarding the desired probiotic properties for a particular disease in question, nor about the final design of the probiotic. Specific strain selection procedures were undertaken to design a disease-specific multispecies probiotic. METHODS: From a strain collection of 69 different lactic acid bacteria a primary selection was made of 14 strains belonging to different species showing superior survival in a simulated gastrointestinal environment. Functional tests like antimicrobial activity against a range of clinical isolates and cytokine inducing capacity in cultured human peripheral blood mononuclear cells were used to further identify potential strains. RESULTS: Specific strains inhibited growth of clinical isolates whereas others superiorly induced the anti-inflammatory cytokine IL-10. Based on functional tests and general criteria regarding probiotic design and safety, a selection of the following six strains was made (Ecologic 641); Bifidobacterium bifidum, Bifidobacterium infantis, Lactobacillus acidophilus, Lactobacillus casei, Lactobacillus salivarius and Lactococcus lactis. Combination of these strains resulted in a wider antimicrobial spectrum, superior induction of IL-10 and silencing of pro-inflammatory cytokines as compared to the individual components. CONCLUSIONS: Application of strict criteria during the design of a disease-specific probiotic prior to implementation in clinical trials may provide a rational basis for use of probiotics
Timmerman L, van Dongen EP, Tromp E, Andriessen EJM, Kerkvliet CTM, Knibbe CAJ. Articaine and lidocaine for spinal anaesthesia in day case surgery. Regional Anesthesia and Pain Medicine 2007; 32(5 suppl 1):9.
Timmermans A, Opmeer BC, Veersema S, Mol BW. Patients' preferences in the evaluation of postmenopausal bleeding. BJOG 2007; 114(9):1146-1149.
Abstract: OBJECTIVE: To assess patients' preferences for diagnostic management of postmenopausal bleeding (PMB). DESIGN: A structured interview. SETTING: A teaching hospital with office hysteroscopy facilities. POPULATION: Thirty-nine women with PMB and with a completed work-up including an office hysteroscopy. METHODS: A structured interview was taken from 39 women who had had an office hysteroscopy in the diagnostic work-up for PMB. Women were informed about the probability of endometrial carcinoma versus benign disease and about advantages and disadvantages of different diagnostic strategies, i.e. expectant management after ultrasound or complete diagnostic work-up, including invasive procedures. MAIN OUTCOME MEASURES: Women were informed about the probability of endometrial carcinoma versus benign disease and about advantages and disadvantages of different diagnostic strategies, i.e., expectant management after ultrasound or complete diagnostic work-up including invasive procedures. Women were asked to make a trade-off between different options. RESULTS: Most women wanted to be 100% certain that carcinoma could be ruled out. Only 5% of the women were willing to accept more than 5% risk of false reassurance. If the risk of recurrent bleeding due to benign disease exceeded 25%, the majority of women would prefer immediate diagnosis and treatment of benign lesions. CONCLUSION: Women with PMB are prepared to undergo hysteroscopy to rule out any risk on cancer. This finding implicates that the measurement of endometrial thickness with transvaginal ultrasound as a first-line test in the assessment of PMB should be reconsidered
Tupker RA. Een open studie over oplopende doses methotrexaat bij matig tot ernstig atopisch eczeem. Nederlands Tijdschrift voor Allergie 2007; 7(4):142.
Tupker RA, Dubois AE, de Groot H, Knulst AC, Lucker GP. Leidraad immunotherapie voor insecten. Nederlands Tijdschrift voor Allergie 2007; 7(2):64-68.
Tupker RA. Allergie voor biociden in polyvinylchloride handschoenen. Nederlands Tijdschrift voor Allergie 2007; 7(1):27.
Tupker RA. Jonge kinderen met constitutioneel eczeem: koemelkvrij dieet? Bijblijven 2007; 23(2):29-33.
Udo EO, Baars HF, Winter JB, Wilde AAM. Not just any ICD device in patients with long-QT syndrome. Netherlands Heart Journal 2007; 15(12):418-421.
Vahl AC, Go PMNYH, de Nie AJ. Richtlijnen zijn de basis voor de integratie van kwaliteit van zorg. Nederlands Tijdschrift voor Heelkunde 2007; 16(5):474-477.
van Binsbergen E, de Weerdt O, Buijs A. A new subtype of MLL-SEPT2 fusion transcript in therapy-related acute myeloid leukemia with t(2;11)(q37;q23): a case report and literature review. Cancer Genetics & Cytogenetics 2007; 176(1):72-75.
Abstract: The t(2;11)(q37;q23) is a rare recurrent cytogenetic abnormality associated with de novo and therapy-related acute myeloid leukemia, resulting in a MLL-SEPT2 fusion gene. We report on a case of therapy-related acute myeloid leukemia M2 showing a t(2;11)(q37;q23) and resulting in a new subtype of a MLL-SEPT2 chimeric transcript. The literature on this translocation is reviewed
van de Garde EM, Souverein PC, Hak E, Deneer VH, van den Bosch JM, Leufkens HG. Angiotensin-converting enzyme inhibitor use and protection against pneumonia in patients with diabetes. Journal of Hypertension 2007; 25(1):235-239.
Abstract: OBJECTIVES: Because of the high risk of pneumonia in patients with diabetes, we aimed to assess the effect of angiotensin-converting enzyme (ACE) inhibitor use on the occurrence of pneumonia in a general population of patients with diabetes. METHODS: The study population comprised all patients in the UK General Practice Research Database who had a diagnosis of diabetes (both type 1 and type 2) between 1987 and 2001. Cases were defined as patients with a first diagnosis of pneumonia. For each case, up to four controls were matched by age, gender, practice, and index date. Patients were classified as current ACE inhibitor user when the index date was between the start and end date of ACE inhibitor therapy. Conditional logistic regression analysis was used to estimate the strength of the association between ACE inhibitor use and pneumonia risk. RESULTS: ACE inhibitors were used in 12.7% of 4719 cases and in 13.7% of 15 322 matched controls [crude odds ratio (OR) = 0.92, 95% confidence interval (CI) = 0.82-1.01]. After adjusting for confounding, ACE inhibitor therapy was associated with a significant reduction in pneumonia risk (adjusted OR = 0.72, 95% CI = 0.64-0.80). The protective association was consistent across different relevant subgroups with the strongest association in patients with a history of stroke. There was a significant dose-effect relationship (P for trend < 0.001). CONCLUSIONS: The use of ACE inhibitors is associated with a significant reduction in pneumonia risk and, apart from blood pressure-lowering properties, may be useful in the prevention of pneumonia in patients with diabetes
van de Garde EM. Congress report: the 41st ASHP clinical meeting. European Journal of Hospital Pharmacy Practice 2007; 13(2):94-96.
van de Garde EM, Oosterheert JJ, Bonten M, Kaplan RC, Leufkens HG. International classification of diseases codes showed modest sensitivity for detecting community-acquired pneumonia. Journal of Clinical Epidemiology 2007; 60(8):8-838.
van de Garde EMW, Endeman H, Deneer VHM, Biesma DH, Ruven HJT, van Velzen-Blad H, Leufkens HGM, van den Bosch JMM. Angiotensin-converting enzyme (ACE) I/D corrected serum ACE activity and severity assessment of community-acquired pneumonia. Clinical Chemistry and Laboratory Medicine 2007; 45(10):1326-1331.
van de Garde EMW, Lange R, Essink G. Kwaliteitscontroles aan radiofarmaca. Nuttig of tijdverspilling? Tijdschrift voor Nucleaire Geneeskunde 2007; 29(2):60-62.
van de Garde EMW, Endeman H, Deneer VHM, Biesma DH, Sayed-Tabatabaei FA, Ruven HJT, Leufkens HGM, van den Bosch JMM. Angiotensin-converting enzyme insertion/deletion polymorphism and risk and outcome of pneumonia. European Respiratory Journal 2007; 30:481S.
van de Garde EMW, Endeman H, Deneer VHM, Biesma DH, Sayed-Tabatabaei FA, Ruven HJT, Leufkens HGM, van den Bosch JMM. Angiotensin-converting enzyme insertion/deletion polymorphism and risk and outcome of pneumonia. Pharmacoepidemiology and Drug Safety 2007; 16:S171.
van de Garde EMW. Drug effects on the risk and prognosis of community-acquired pneumonia. Gildeprint Drukkerijen: Enschede, 2007.
van de Wal RM, van Werkum JW, le Cocq d'Armandville MC, Plokker HW, Morshuis WJ. Giant aneurysm of an aortocoronary venous bypass graft compressing the right ventricle. Netherlands Heart Journal 2007; 15(7-8):252-254.
Abstract: A 69-year-old man with a history of coronary artery bypass grafting and a recent inferoposterior myocardial infarction presented to the hospital for diagnostic coronary angiography. Physical examination, laboratory analyses, coronary angiography, echocardiography, and CT scan were performed. A giant aneurysm of the aortocoronary venous bypass graft, associated with compression of the right side of the heart, was revealed. After surgical resection and replacement of the venous graft the patient died due to right ventricular failure. (Neth Heart J 2007;15:252-4.Neth Heart J 2007;15:252-4.)
van de Wal RM, van der Harst P, Wagenaar LJ, Wassmann S, Morshuis WJ, Nickenig G, Buikema H, Plokker HW, van Veldhuisen DJ, van Gilst WH, Voors AA. Angiotensin II type 2 receptor vasoactivity in internal mammary arteries of patients with coronary artery disease. Journal of Cardiovascular Pharmacology 2007; 50(4):372-379.
Abstract: BACKGROUND: Several animal studies suggested that the angiotensin II type 2 (AT2) receptor subtype mediates vasodilation, yet the results in human arteries are less well described and more inconsistent. Therefore, we evaluated the role of the AT2 receptor stimulation on the vasotonus of human internal mammary arteries. METHODS: Internal mammary arteries were obtained from 50 patients undergoing coronary bypass surgery. The expression of angiotensin II type 1 (AT1) receptor and AT2 receptor mRNA was determined by using real-time polymerase chain reaction. In addition, angiotensin II and CGP42112A concentration-response curves (concentration range: 10(-10) M to 10(-6) M) were constructed in absence or presence of candesartan (10(-5) M) and/or the AT2 receptor-antagonist PD-123319 (10(-6) M) and/or the alpha receptor antagonist phentolamine. RESULTS: Both AT1 and AT2 receptor protein and mRNA were detected, and higher AT2 receptor mRNA expression levels were associated with increased contractile response to angiotensin II. Angiotensin II caused vasoconstriction up to 41.1 +/- 6.5% of the maximal response to phenylephrine, and PD123319 significantly reduced this response (28.6 +/- 9.6%, P < 0.001). Candesartan completely blocked the angiotensin II-mediated response (1.4 +/- 3.1%, P < 0.001 versus control), and additional blockade of the AT2 receptor with PD123319 did not change this effect (1.8 +/- 5.1%). Phentolamine (10(-5) M) caused attenuation and rightward shift of the angiotensin II concentration response curves. The AT2 receptor agonist CGP42112A did not induce a significant response. CONCLUSION: Although AT2 receptor mRNA is present in human internal mammary arteries, AT2 receptor stimulation does not mediate vasodilation in these arteries
van de Wal RM, van der Harst P, Gerritsen WB, van der Horst FAL, Plokker TH, Gansevoort RT, van Gilst WH, Voors AA. Plasma matrix metalloproteinase-9 and ACE-inhibitor-induced improvement of urinary albumin excretion in non-diabetic, microalbuminuric subjects. Journal of the Renin-Angiotensin-Aldosterone System 2007; 8(4):177-180.
Abstract: INTRODUCTION: Elevated plasma matrix metalloproteinase-9 (MMP-9) levels have been suggested to precede the development of microalbuminuria. As angiotensin-converting enzyme (ACE) inhibitors effectively reduce urinary albumin excretion (UAE), in the present study we have investigated the potential association of plasma MMP-9 levels with UAE and treatment effects of ACE-inhibition. MATERIAL AND METHODS: In a placebo-controlled randomised trial we determined plasma MMP-9 levels at baseline and after three months of randomisation to either placebo (n=202) or fosinopril (20 mg/day, n=204) treatment. RESULTS: Baseline plasma MMP-9 levels were not related to baseline UAE (r=-0.008, p=0.871). Three months of fosinopril treatment effectively reduced UAE compared to placebo treatment (-10.4+/-2.4 vs. 1.8+/-1.3 mg/24 hours, p<0.001, respectively). However, fosinopril treatment failed to significantly change plasma MMP-9 levels compared to placebo (-0.47+/-7.68 vs. 0.06+/-9.20, p=0.646, respectively). In addition, the change in UAE was not related with change in MMP-9 levels. CONCLUSION: The effective reduction of UAE with fosinopril was not related to plasma MMP-9 levels
van den Bergh RCN, Moll FL, de Vries JPPM, Yeung KK, Lock MTWT. Arterio-ureterale fistels. Urologie 2007; 15(1):22-26.
van den Bosch JMM, Bottema BJAM, Lammers J-WJ, Zaagsma J. Het pulmonaal formularium : een praktische leidraad. 5e herziene ed. Houten: Bohn Stafleu Van Loghum, 2007.
van den Bosch JMM, Deneer VHM. Longtransplantatie. In: van den Bosch JMM, Bottema BJAM, Lammers J-WJ, Zaagsma J, editors. Het pulmonaal formularium : een praktische leidraad. Houten: Bohn Stafleu Van Loghum, 2007: 192-203.
van den Bosch JMM, Grutters JC. Idiopathische pulmonale fibrose. Pulmo-Didact 2007; 10(2).
van den Broek T, Liqui Lung PF, Suttorp MJ, Eefting FD, Schipper ME, Vink A. Arterial occlusion after repetitive angio-seal device closure. Vascular & Endovascular Surgery 2007; 41(4):346-347.
van den Broek T, Liqui Lung PF, Suttorp MJ, Eefting FD, Schipper ME, Vink A. Vascular occlusion as a late complication of the Angio-Seal closure device. A review of literature. Minerva Cardioangiologica 2007; 55(6):815-819.
Abstract: Although early vascular complications of the Angio-Seal closure device have been well described, little is known about late vascular complications due to this device. The aim of this paper is to discuss late femoral stenosis associated with the use of the Angio-Seal closure device. A literature search was performed using Medline', Embase' and The Cochrane Library' to identify relevant articles published up to the first of May 2007. Late occlusion was defined as an occlusion after approximately one week after Angio-Seal deployment. All together, eleven relevant papers were available. The reported prevalence of late vascular stenosis associated with Angio-Seal use varies between 1/961 and 4/175. Claudication was the most frequently reported complaint. In most cases, late stenosis due to the use of the Angio-Seal required surgery. Vascular obstruction due to the device has been reported up to 6 months after placement. In conclusion, vascular stenosis due to the use an Angio-Seal closure device is a complication that not only occurs in the first few days after placement, but also in the following months. In every patient developing complaints of arterial insufficiency after using an Angio-Seal, local arterial stenosis due to the device should be considered in the differential diagnosis. It therefore is important to register the use of the device in the patient chart
van der Ent CK, Hoekstra H, Rijkers GT. Successful treatment of allergic bronchopulmonary aspergillosis with recombinant anti-IgE antibody. Thorax 2007; 62(3):276-277.
Abstract: Allergic bronchopulmonary aspergillosis (ABPA) can cause severe worsening of the respiratory condition in patients with cystic fibrosis. Treatment can result in steroid dependency and serious adverse events. A dramatic and rapid improvement of respiratory symptoms and lung function after a single dose of anti-IgE antibody (omalizumab) in a 12-year-old girl with cystic fibrosis and ABPA is described. This is the first report of this experimental treatment. It suggests an important role for IgE in the pathogenesis of ABPA and offers new therapeutic possibilities
van der Gaag NA, de Castro SM, Rauws EA, Bruno MJ, van Eijck CH, Kuipers EJ, Gerritsen JJ, Rutten JP, Greve JW, Hesselink EJ, Klinkenbijl JH, Rinkes IH, Boerma D, Bonsing BA, van Laarhoven CJ, Kubben FJ, van der Harst E, Sosef MN, Bosscha K, de Hingh I, de Wit LTh, van Delden OM, Busch OR, van Gulik TM, Bossuyt PM, Gouma DJ. Preoperative biliary drainage for periampullary tumors causing obstructive jaundice; DRainage vs. (direct) OPeration (DROP-trial). BMC Surgery 2007; 7:3.
Abstract: BACKGROUND: Surgery in patients with obstructive jaundice caused by a periampullary (pancreas, papilla, distal bile duct) tumor is associated with a higher risk of postoperative complications than in non-jaundiced patients. Preoperative biliary drainage was introduced in an attempt to improve the general condition and thus reduce postoperative morbidity and mortality. Early studies showed a reduction in morbidity. However, more recently the focus has shifted towards the negative effects of drainage, such as an increase of infectious complications. Whether biliary drainage should always be performed in jaundiced patients remains controversial. The randomized controlled multicenter DROP-trial (DRainage vs. Operation) was conceived to compare the outcome of a 'preoperative biliary drainage strategy' (standard strategy) with that of an 'early-surgery' strategy, with respect to the incidence of severe complications (primary-outcome measure), hospital stay, number of invasive diagnostic tests, costs, and quality of life. METHODS/DESIGN: Patients with obstructive jaundice due to a periampullary tumor, eligible for exploration after staging with CT scan, and scheduled to undergo a "curative" resection, will be randomized to either "early surgical treatment" (within one week) or "preoperative biliary drainage" (for 4 weeks) and subsequent surgical treatment (standard treatment). Primary outcome measure is the percentage of severe complications up to 90 days after surgery. The sample size calculation is based on the equivalence design for the primary outcome measure. If equivalence is found, the comparison of the secondary outcomes will be essential in selecting the preferred strategy. Based on a 40% complication rate for early surgical treatment and 48% for preoperative drainage, equivalence is taken to be demonstrated if the percentage of severe complications with early surgical treatment is not more than 10% higher compared to standard treatment: preoperative biliary drainage. Accounting for a 10% dropout, 105 patients are needed in each arm resulting in a study population of 210 (alpha = 0.95, beta = 0.8). DISCUSSION: The DROP-trial is a randomized controlled multicenter trial that will provide evidence whether or not preoperative biliary drainage is to be performed in patients with obstructive jaundice due to a periampullary tumor
van der Heyden J, Ascoop C. Na een geslaagde dotterbehandeling wegens angina pectoris laat het klinisch herstel soms langer op zich wachten. In andere gevallen is de patiënt meteen klachtenvrij. Hoe is dit te verklaren? Cardiologen Vademecum 2007; 10(10).
van der Heyden J, Suttorp MJ, Bal ET, Ernst JM, Ackerstaff RG, Schaap J, Kelder JC, Schepens M, Plokker HW. Staged carotid angioplasty and stenting followed by cardiac surgery in patients with severe asymptomatic carotid artery stenosis: early and long-term results. Circulation 2007; 116(18):2036-2042.
Abstract: BACKGROUND: The strategy for treating patients with severe asymptomatic carotid artery stenosis and cardiac disease remains unresolved. Staged or combined carotid endarterectomy in these patients offers the potential benefit of decreased neurological morbidity during and after cardiac surgery; however, in high-risk patients with severe coronary artery disease, chronic obstructive pulmonary disease, or renal impairment, the incidence of death and stroke is significantly higher. METHODS AND RESULTS: We report the results of a prospective, single-center study designed to evaluate the feasibility and safety of carotid artery angioplasty and stenting (CAS) before cardiac surgery in neurologically asymptomatic patients. The periprocedural and long-term outcomes of 356 consecutive patients who underwent CAS before cardiac surgery were analyzed. The procedural success rate of CAS was 97.7%. The death and stroke rate from time of CAS to 30 days after cardiac surgery was 4.8% (n=17). The myocardial infarction rate from time of CAS to 30 days after cardiac surgery was 2.0% (n=7), and the combined death, stroke, and myocardial infarction rate was 6.7% (n=24). Distal embolic protection devices were used in 40% of the cases. CONCLUSIONS: This large cohort of asymptomatic patients who underwent staged CAS and cardiac surgery experienced a low periprocedural complication rate. The high rate of freedom from death and stroke during the 5 years of follow-up supports the long-term durability of this approach. Our findings suggest that this new strategy may become a valuable alternative in the treatment of patients with combined carotid and cardiac disease
van der Lee I, Zanen P, Stigter N, van den Bosch JM, Lammers JW. Diffusing capacity for nitric oxide: reference values and dependence on alveolar volume. Respiratory Medicine 2007; 101(7):1579-1584.
Abstract: Nitric oxide (NO) has a much stronger affinity for hemoglobin than carbon monoxide (CO); therefore, the DL(NO) (diffusing capacity for NO) is less influenced by changes in capillary blood volume than the DL(CO) (diffusing capacity for CO), and represents the true membrane diffusing capacity. We measured the combined single breath DL(NO)/DL(CO) in 124 healthy subjects, and generated reference equations for the DL(NO) and K(NO). In a subset of 21 subjects the measurements were performed on different inspiratory levels. The reference equation for DL(NO) in females is 53.47*H(height)0.077*A(age)-48.28(RSD5.22) and for males 59.84*H-0.25*A-44.20(RSD6.39). Reference equations for K(NO) in females is -2.03*H-0.025*A+11.52(RSD0.48) and for males -0.15*H-0.045*A+9.47(RSD0.65). The K(CO) (DL(CO)/V(A)) increases when V(A) (alveolar volume) decreases, probably due to an increase of blood volume per unit lung volume. The DL(NO) was much stronger related to the V(A), the K(NO) was almost independent of V(A). Because of the relative independence of the K(NO) on V(A), the K(NO) appears to be a much better index for the diffusion capacity per unit lung volume (transfer coefficient) than the K(CO)
van der Linden AS, van Es HW. Case 112: pituitary stalk transection syndrome with ectopic posterior pituitary gland. Radiology 2007; 243(2):594-597.
van der Linden AS, van Es HW. Case 112. Radiology 2007; 242(1):302-304.
van der Putten K, Braam RL, Gaillard CAJM. Hartfalen : een systemische aandoening. In: Voors AA, Kirkels JH, editors. Leerboek hartfalen. Houten: Bohn Stafleu Van Loghum, Healthcare Communications, 2007: 47-69.
van der Steeg JW, Steures P, Eijkemans MJ, Habbema JD, Hompes PG, Broekmans FJ, van Dessel HJ, Bossuyt PM, van der Veen F, Mol BW, on behalf of Cecerm study group, Schagen van Leeuwen JH. Pregnancy is predictable: a large-scale prospective external validation of the prediction of spontaneous pregnancy in subfertile couples. Human Reproduction 2007; 22(2):536-542.
Abstract: BACKGROUND: Prediction models for spontaneous pregnancy may be useful tools to select subfertile couples that have good fertility prospects and should therefore be counselled for expectant management. We assessed the accuracy of a recently published prediction model for spontaneous pregnancy in a large prospective validation study. METHODS: In 38 centres, we studied a consecutive cohort of subfertile couples, referred for an infertility work-up. Patients had a regular menstrual cycle, patent tubes and a total motile sperm count (TMC) >3 x 10(6). After the infertility work-up had been completed, we used a prediction model to calculate the chance of a spontaneous ongoing pregnancy (www.freya.nl/probability.php). The primary end-point was time until the occurrence of a spontaneous ongoing pregnancy within 1 year. The performance of the pregnancy prediction model was assessed with calibration, which is the comparison of predicted and observed ongoing pregnancy rates for groups of patients and discrimination. RESULTS: We included 3021 couples of whom 543 (18%) had a spontaneous ongoing pregnancy, 57 (2%) a non-successful pregnancy, 1316 (44%) started treatment, 825 (27%) neither started treatment nor became pregnant and 280 (9%) were lost to follow-up. Calibration of the prediction model was almost perfect. In the 977 couples (32%) with a calculated probability between 30 and 40%, the observed cumulative pregnancy rate at 12 months was 30%, and in 611 couples (20%) with a probability of >or=40%, this was 46%. The discriminative capacity was similar to the one in which the model was developed (c-statistic 0.59). CONCLUSIONS: As the chance of a spontaneous ongoing pregnancy among subfertile couples can be accurately calculated, this prediction model can be used as an essential tool for clinical decision-making and in counselling patients. The use of the prediction model may help to prevent unnecessary treatment
van der Stelt CA, van Werkum JW, Seesing TH, ten Berg JM, Hackeng CM. To adjust or not to adjust the platelet count in light transmission aggregometry in patients receiving dual aspirin/clopidogrel treatment. Platelets 2007; 18(7):550-553.
Abstract: We evaluated whether the results of light transmittance aggregometry (LTA) differ when "native" platelet-rich plasma (PRP) or adjusted (to a standard platelet count of 250.000/microL) PRP is used in patients on dual antiplatelet therapy with aspirin and clopidogrel. LTA has been performed on the blood of 142 stable angina pectoris patients who were adequately pretreated with aspirin and clopidogrel. Platelet aggregation was significant higher in native PRP as compared to platelet count adjusted PRP (P<0.0001) for all four concentrations of adenosine-5'-diphosphate (ADP) (2, 5, 10 and 20 mumol/L). The interindividual variability was significantly higher in platelet count adjusted PRP as compared to native PRP when stimulated with 10 and 20 mumol/L of ADP. The absolute magnitude of aggregation in non-adjusted PRP is clearly dependent on platelet number. These observations are important since several studies have used empirically defined cut-off levels to segregate non-responders from responders to clopidogrel therapy
van der Veer WM, Verbeek WHM, Visser OJ, Al-Toma A, Mulder CJJ, Jacobs MAJM. Enteropathiegeassocieerd T-cellymfoom bij refractaire coeliakie: is doubleballon-enteroscopie de sleutel voor de diagnostiek? Nederlands Tijdschrift voor Oncologie 2007;(7):316-322.
van der Velden AM, Claessen AM, van Velzen-Blad H, Biesma DH, Rijkers GT. Development of T cell-mediated immunity after autologous stem cell transplantation: prolonged impairment of antigen-stimulated production of g-interferon. Bone Marrow Transplant 2007; 40(3):261-266.
Abstract: The conditioning regimens for autologous SCT (auto-SCT) lead to impairment of the immune system and concomitant increase in susceptibility to infections. We studied the recovery of cellular immunity by in vitro analysis of T-cell proliferation and cytokine production profiles during the first 15 months after auto-SCT in patients with multiple myeloma and non-Hodgkin's lymphoma. PBMC were collected at 6, 9 and 15 months after transplantation and stimulated with a combination of CD2 and CD28 monoclonal antibodies, with PHA or with tetanus toxoid as recall antigen. A multiplex enzyme linked immunoassay was used to determine levels of Th1 cytokines IL-2, IFN-gamma and tumour-necrosis factor-alpha (TNF-alpha), Th2 cytokines IL-4, IL-5 and IL-13, the regulatory cytokine IL-10 and the proinflammatory cytokines IL-1alpha, IL-1beta, IL-6 and the chemokine IL-8. T-cell proliferation progressively increased from 6 to 15 months after auto-SCT. Overall, cytokine production increased after auto-SCT. Production of Th2 cytokines IL-5 and IL-13 was superior to production of Th1 cytokines IFN-gamma and TNF-alpha. We hypothesize that prolonged impairment of IFN-gamma production might contribute to the relatively high incidence of viral infections after auto-SCT.Bone Marrow Transplantation (2007) 40, 261-266; doi:10.1038/sj.bmt.1705706; published online 11 June 2007
van der Velden AM, Claessen AM, van Velzen-Blad H, de Groot MR, Kramer HM, Biesma DH, Rijkers GT. Vaccination responses and lymphocyte subsets after autologous stem cell transplantation. Vaccine 2007; 25(51):8512-8517.
Abstract: Twenty autologous stem cell transplant recipients were vaccinated with three doses of Diphtheria-Tetanus-Poliomyelitis vaccine and conjugated Haemophilus influenzae type b (Hib) vaccine. Pneumococcal vaccination consisted of two doses of conjugated vaccine followed by a single dose of polysaccharide vaccine, at 6, 8 and 14 months after transplantation, respectively. Mean anti-tetanus, anti-Hib and anti-pneumococcal IgG antibodies significantly increased after each vaccination. Response rates after the full vaccination schedule were 94%, 78% and 61% for Hib, conjugated 7-valent pneumococcal vaccine and non-conjugated 23-valent pneumococcal vaccine, respectively. Three months after transplantation, CD16(+)CD56(+) NK cells were in the normal range and remained so. The total number of T lymphocytes at 3 months was and remained in the normal range. The mean CD4/CD8 ratio was 0.43 at 3 months post aSCT and, while gradually increasing, remained subnormal. The mean number of CD19(+) B lymphocytes significantly increased during the study period. Patients with CD19 counts <0.10x10(9)L(-1) required at least two Hib vaccinations to show a response, while the majority of patients with CD19 counts >/=0.20x10(9)L(-1) showed a response to Hib after one vaccination only. Thus, a minimum threshold level of CD19(+) cells appears to be required for adequate responses to vaccination
van der Velden AMT. Antibody responses to vaccination and immune function in patients with haematological malignancies : studies in patients with chronic lymphocytic leukaemia and autologous stem cell transplant recipients. Ouderkerk aan de Amstel: Drukkerij Aeroprint, 2007.
van der Velden AMT, van Velzen-Blad H, Claessen AME, van der Griend R, Oltmans R, Rijkers GT, Biesma DH. The effect of ranitidine on antibody responses to polysaccharide vaccines in patients with B-cell chronic lymphocytic leukaemia. European Journal of Haematology 2007; 79(1):47-52.
Abstract: Abstract Objectives: To analyse the effects of ranitidine treatment on vaccination induced antibody responses in patients with chronic lymphocytic leukaemia (CLL).Methods: Fifty CLL patients were vaccinated with tetanus conjugated Hib vaccine and a 23-valent pneumococcal polysaccharide vaccine with (n = 25) or without (n = 25) ranitidine treatment in a matched case--control setting. Anti tetanus toxoid (TT), anti-Hib and anti-pneumococcal antibody levels were determined before and after vaccination. Additionally, cytokine levels were assessed in patients treated with ranitidine.Results: Vaccination-induced increases in anti-Hib and anti-TT antibody levels were higher in the ranitidine group compared with the control group. Anti-pneumococcal antibody responses were not improved by administration of ranitidine. Higher levels of IL-18 were found in patients treated with ranitidine compared with healthy controls. Levels of IL-6, IL-8, IL-18, RANTES, IP-10, sVCAM-1 and sICAM-1 were within normal ranges and did not change during ranitidine treatment.Conclusion: Ranitidine treatment improves vaccination-induced T-cell dependent antibody responses in patients with CLL but has no beneficial effect on the response to vaccination with unconjugated polysaccharide antigens
van der Waal R, van der Waal I. Oral non-squamous malignant tumors; diagnosis and treatment. Medicina oral, patología oral y cirugía bucal 2007; 12(7):E486-E491.
Abstract: Some 90% of oral cancers consist of squamous cell carcinomas that arise from the oral mucosa. The remaining 10% of malignancies consist of malignant melanomas, carcinomas of the intraoral salivary glands, sarcomas of the soft tissues and the bones, malignant odontogenic tumors, non-Hodgkin's lymphomas and metastases from primary tumors located elsewhere in the body. These malignancies will be briefly reviewed and discussed. The emphasis is on diagnosis and management
van der Waal RIF, de Visscher JGAM, van der Waal I. Huidafwijkingen in het aangezicht. Een overzicht voor tandartsen. Nederlands Tijdschrift voor Tandheelkunde 2007; 114:271-277.
van Deurzen CH, van Hillegersberg R, Hobbelink MG, Seldenrijk CA, Koelemij R, van Diest PJ. Predictive value of tumor load in breast cancer sentinel lymph nodes for second echelon lymph node metastases. Cellular oncology 2007; 29(6):497-505.
Abstract: Background: The need for routine axillary lymph node dissection (ALND) in patients with invasive breast cancer and low-volume sentinel node (SN) involvement is questionable. Accurate prediction of second echelon lymph node involvement could identify those patients most likely to benefit from ALND.Methods: A consecutive series of 317 patients with invasive breast cancer and a tumor positive axillary SN followed by ALND was reviewed. Clinicopathologic features of the primary tumor and the SN were assessed as possible predictors of second echelon lymph node involvement.Results: Second echelon metastases were found in 116/317 cases (36.6%). Frequency of second echelon lymph node involvement in patients with isolated tumor cells (ITC, N=23), micro- (N=101) and macrometastases (N=193) was 13%, 20% and 48%, respectively (p<0.001). Based on the area % of SN occupied by tumor no subgroup of patients could be selected with less than 20% second echelon lymph node involvement. However, none of the patients with SN ITC or micrometastases and a primary tumor size </=1 cm (N=12, 3.8%) had second echelon lymph node involvement.Conclusions: Accurately measured SN tumor load predicts second echelon lymph node involvement. However, even in patients with ITC, the second echelon lymph nodes are involved in 13% justifying ALND
van Dijk A, Gelderblom E, van de Garde EMW, Tiel-van Buul MMC, Verzijlbergen FJ, Lavalaye J. Astonish versus OSEM reconstruction in bone SPECT of the lumbar spine. European Journal of Nuclear Medicine & Molecular Imaging 2007; 34(Suppl 2):S127-S128.
van Dijk BA, Kemna EH, Tjalsma H, Klaver SM, Wiegerinck ET, Goossens JP, Slee PH, Breuning MH, Swinkels DW. Effect of the new HJV-L165X mutation on penetrance of HFE. Blood 2007; 109(12):5525-5526.
van Dijk D, Spoor M, Hijman R, Nathoe HM, Borst C, Jansen EW, Grobbee DE, de Jaegere PP, Kalkman CJ, for the Octopus Study Group, van Boven WJ, Ernst JM. Cognitive and cardiac outcomes 5 years after off-pump vs on-pump coronary artery bypass graft surgery. JAMA 2007; 297(7):701-708.
Abstract: CONTEXT: Conventional coronary artery bypass graft surgery with use of cardiopulmonary bypass (on-pump CABG) is associated with excellent long-term cardiac outcomes but also with a high incidence of cognitive decline. The effect of avoiding cardiopulmonary bypass (off-pump CABG) on long-term cognitive and cardiac outcomes is unknown. OBJECTIVE: To compare the effect of off-pump CABG and on-pump CABG surgery on long-term cognitive and cardiac outcomes. DESIGN, SETTING, AND PARTICIPANTS: The Octopus Study, a multicenter randomized controlled trial conducted in the Netherlands, which enrolled 281 low-risk CABG patients between 1998 and 2000. Five years after their surgery, surviving patients were invited for a follow-up assessment. INTERVENTION: Patients were randomly assigned to receive either off-pump (n = 142) or on-pump (n = 139) CABG surgery. MAIN OUTCOME MEASURE: The primary measure was cognitive status 5 years after surgery, which was determined by a psychologist blinded to treatment allocation who administered 10 standardized validated neuropsychological tests. Secondary measures were occurrence of cardiovascular events (all-cause mortality, stroke, myocardial infarction, and coronary reintervention), anginal status, and quality of life. RESULTS: After 5 years, 130 patients were alive in each group. Cognitive outcomes could be determined in 123 and 117 patients in the off-pump and on-pump groups, respectively. When using a standard definition of cognitive decline (20% decline in performance in 20% of the neuropsychological test variables), 62 (50.4%) of 123 in the off-pump group and 59 (50.4%) of 117 in the on-pump group had cognitive decline (absolute difference, 0%; 95% confidence interval [CI], -12.7% to 12.6%; P>.99). When a more conservative definition of cognitive decline was used, 41 (33.3%) in the off-pump group and 41 (35.0%) in the on-pump group had cognitive decline (absolute difference, -1.7%; 95% CI, -13.7% to 10.3%; P = .79). Thirty off-pump patients (21.1%) and 25 on-pump patients (18.0%) experienced a cardiovascular event (absolute difference, 3.1%; 95% CI, -6.1% to 12.4%; P = .55). No differences were observed in anginal status or quality of life. CONCLUSION: In low-risk patients undergoing CABG surgery, avoiding the use of cardiopulmonary bypass had no effect on 5-year cognitive or cardiac outcomes. TRIAL REGISTRATION: isrctn.org Identifier: ISRCTN69438133
van Dijk N, Boer MC, de Santo T, Grovale N, Aerts AJ, Boersma L, Wieling W. Daily, weekly, monthly, and seasonal patterns in the occurrence of vasovagal syncope in an older population. Europace 2007; 9(9):823-828.
Abstract: AIMS: The aim of this study was to assess the frequency of vasovagal episodes over the day, week, month, and seasons. METHODS AND RESULTS: This study was part of the multi-centre International Study on Syncope of Uncertain Etiology-2 (ISSUE-2), which included patients, aged 30 years or older, with severe neurally mediated syncope between June 2002 and July 2004. The Implantable Loop Recorder (ILR) was used to document the syncope-related ECG periods. For this study patients with recorded syncopal episodes after ILR-implantation was selected. At least one episode was documented in 106 patients. A higher number of episodes were documented during the morning than during other periods of the day (P < 0.01). There was no difference between various days of the week, episodes per month, or between seasons. There was no difference between age and gender groups, although elderly patients seemed to be responsible for the peak in the morning. CONCLUSION: A circadian pattern in the frequency of vasovagal episodes exists, with a peak in the morning. This is in accordance with reports of diurnal variations in blood pressure and heart rate. No difference was observed in syncope distribution between days of the week, months, or seasons
van Dongen HPA. Anesthesie bij vaatchirurgie. In: Hennis PJ, Leusink JA, editors. Anesthesiologie. Houten: Bohn Stafleu Van Loghum, 2007: 427-437.
van Eck JWM, van Hemel NM, Zuithof P, van Asseldonk JPM, Voskuil TLHM, Grobbee DE, Moons KGM. Incidence and predictors of in-hospital events after first implantation of pacemakers. Europace 2007; 9:884-889.
Abstract: Aims Despite an annual rise in the numbers of patients receiving their first pacemaker (PM), the risks of the implantation procedure remains unclear. The purpose of this prospective study is to estimate the incidence of in-hospital events after first PM implantation and to determine the predictors of these events. Methods and results Patients with conventional pacing diagnosis were included in the Dutch multicentre FOLLOWPACE PM registry that prospectively documented patients' prognosis and quality of life, and PM events after first implantation. From these registry characteristics, implantation data and in-hospital findings were analysed as potential predictors for events in a sample of 1198 patients. In 111 patients studied, at least one serious in-hospital event occurred (incidence 10.1%, 95%CI: 8.9-12.3). Six variables, i.e. a lower body mass index, presence of heart failure in medical history, main indication for implantation, vena subclavia use for venous access, active atrial lead fixation, and the implantation of a dual chamber system, were found to be independent predictors of events after first PM implantation. The overall multivariable model yielded an ROC area of 0.65 (95%CI: 0.60-0.70). Conclusion This large prospective multicentre study identified six variables as independent predictors for serious in-hospital events after first implantation. This may assist the implanting cardiologist and surgeon to identify patients at higher risk, during and immediately after PM implantation
van Geest-Daalderop JH, Hutten BA, Pequeriaux NC, Haas FJ, Levi M, Sturk A. The influence on INRs and coagulation factors of the time span between blood sample collection and intake of phenprocoumon or acenocoumarol: consequences for the assessment of the dose. Thrombosis & Haemostasis 2007; 98(4):738-746.
Abstract: Managing treatment with vitamin K antagonists, the prothrombin time (PT), expressed as international normalized ratio (INR), may not represent the INR during the entire 24 hour (h) period, and this variation may be different between long-acting phenprocoumon and short-acting acenocoumarol. For both drugs we investigated the variation in 24 h of the PT/INR, the consequencesfor the assessment of the doses and which vitamin K-dependent factor causes the daily variation. Patients on self-management took their medication at 6 p.m. and determined their INRs for eight weeks, once a week and three times daily (8.30 a.m., 6 p.m. and 11 p.m., thus 14.5 h, 24 h and 29 h after taking the medication, respectively). Acenocoumarol showed a significant variation in INRs over the 24 h period, with 22 out of 80 INRs >20% lower at 11 p.m. versus 8.30 a.m. Phenprocoumon showed only few variations. Patients managed by the anticoagulation clinic took their medication at 6 p.m. for four weeks and then at 8 a.m. for four weeks, 15 h and 25 h, respectively, before the weekly blood collection. PT/INR and coagulation factors VII, X and II were determined. With acenocoumarol, taken 25 h before blood collection, the INRs were significantly different compared to 15 h, especially attributed to plasma levels of factor VII. Those on phenprocoumon were equal. These variations of INRs during 24 h may have major effects on the prescribed dose of short-acting vitamin K antagonists, such as acenocoumarol, especially for INRs at the limits of the therapeutic ranges
van Geldrop M, Schepens M. Pijn op de borst (2). In: Hoving GK, Somsen GA, editors. Probleemgeoriënteerd denken in de cardiologie : een praktijkboek voor de opleiding en de kliniek. Utrecht: De Tijdstroom, 2007: 159-173.
van Hannen EJ, Kool L, de Jongh BM. Development of a multiplex PCR to detect the presence of blaTEM, blaSHV, blaCTX-M and qnrA1 genes. Nederlands Tijdschrift voor Medische Microbiologie 2007; 15(Suppl):P039.
van Hattum ES, de Vries JP, Lalezari F, van den Berg JC, Moll FL. Angioplasty with or without Stent Placement in the Brachiocephalic Artery: Feasible and Durable? A Retrospective Cohort Study. Journal of Vascular & Interventional Radiology 2007; 18(9):1088-1093.
Abstract: Purpose To evaluate the results of percutaneous transluminal angioplasty (PTA) and stent placement in isolated brachiocephalic trunk lesions. Materials and Methods PTA, with or without stent placement, was used to treat 30 patients with isolated clinically significant stenoses (n = 25) or occlusions (n = 5) of the brachiocephalic artery. Initial clinical success was defined as a relief or substantial reduction of the preprocedural symptoms, and initial technical success was defined as a mean translesion pressure gradient of less than 5 mm Hg or a residual stenosis of less than 20%. Clinical evaluation and duplex Doppler ultrasonography of the lesion site were performed at follow-up. Clinical restenosis was defined as recurrent clinical symptoms and a lumen reduction of more than 50%, determining the primary clinical patency. Technical restenosis was defined as more than 50% lumen reduction with or without renewed clinical symptoms, determining the primary technical patency. Results The initial technical success rate was 83% (occlusions, 60%; stenoses, 88%), and the clinical success rate was 81%. Two patients had major complications, and four experienced minor complications. At a median follow-up of 24 months (4 weeks to 92 months), the primary clinical patency rate was 79% (95% confidence interval [CI]: 57%, 104%), with 83% (95% CI: 60%, 105%) for arteries with stents and 67% (95% CI: 13%, 120%) for those without stents (P = .11). The primary technical patency rate was 50% (95% CI: 24%, 76%). Conclusion PTA with or without stent placement in a stenotic or occlusive brachiocephalic artery is a procedure of tolerable safety with a high initial success rate; however, only moderately rewarding results were obtained after 2 years. Selective stent placement probably improves long-term success. Primary PTA with selective stent placement in an atherosclerotic obstructive brachiocephalic artery should be considered the preferred treatment option
van Hees BC, Veldman-Ariesen MJ, de Jongh BM, Tersmette M, van Pelt W. Regional and seasonal differences in incidence and antibiotic resistance of Campylobacter from a nationwide surveillance study in The Netherlands: an overview of 2000–2004. Clinical Microbiology & Infection 2007; 13(3):305-310.
van Hemel NM, de Jongh BM. Bestaat er bij endoscopische ingrepen / onderzoeken aan de luchtwegen bij bepaalde hartklepvitia een indicatie voor endocarditisprofylaxe? Longartsen Vademecum 2007; 10(15).
van Hemel NM, Holwerda KJ, Slegers PC, Spierenburg HA, Timmermans AA, Meeder JG, van der Kemp P, Kelder JC, Stofmeel MA, on behalf of the Sensor and Quality of Life (SQL) investigators. The contribution of rate adaptive pacing with single or dual sensors to health-related quality of life. Europace 2007; 9(4):233-238.
Abstract: AIMS: The characteristics of sensors to perform rate adaptive pacing are well established but whether their contribution improves health-related quality of life (QoL) remains disputable. To compare the effects on QoL with an integrated dual sensor [minute ventilation (MV) and acceleration, TT sensor] with a single MV sensor, and with no rate adaptive pacing. METHODS AND RESULTS: This Dutch multi centre, prospective, single- (patient) blind study was performed in patients after first pacemaker (PM) implant for sick sinus syndrome or AV block. After a 3-month 'sensor off'-period following DDD PM implantation, where the latter 2 months permitted the MV sensor to learn the intrinsic rhythm, a 2-month period of DDDR with TT sensor or 2 months of DDDR with MV sensor, subsequently the two modes were crossed over. Quality of life was determined with Aquarel, the disease-specific instrument for PM patients. Heart rate, percentages of sensor driven and intrinsic rhythm were retrieved from PM memories. Sixty-four patients completed the 7-month study. In sick sinus patients, percentages of sensor-driven pacing occurred significantly more frequently than in AV block patients After implant QoL improved significantly: before 71.3 and after 83.5% (P < 0.001) measured with Aquarel and in 3 of 9 SF-36 scales, but no significant additive QoL benefit with dual or MV sensor pacing was observed. Pacing diagnosis, percentages of rate adaptive pacing, and heart rate influencing medication did not influence this result. CONCLUSION: Pacemaker implantation strongly improves QoL, but neither single- nor dual- sensor-driven pacing offered additional improvement in QoL during the initial 8 months after the first PM implant
van Herwaarden JA, van de Pavoordt ED, Waasdorp EJ, Vos JA, Overtoom TTh, Kelder JC, Moll FL, de Vries JP. Long-term single-center results with AneuRx endografts for endovascular abdominal aortic aneurysm repair. Journal of Endovascular Therapy 2007; 14(3):307-317.
Abstract: Purpose: To evaluate the long-term single-center results with the AneuRx stent-graft in endovascular abdominal aortic aneurysm (AAA) repair (EVAR). Methods: Between December 1996 and August 2003, 212 patients (197 men; mean age 71.3+/-7.0 years) were treated with the AneuRx stent-graft for an infrarenal AAA. Postoperatively, patients were enrolled in a fixed surveillance protocol, and data were prospectively captured into a database. Results: Graft deployment was successful in 98.6% (209/212). Thirty-day mortality was 2.4%. Median hospital stay was 4.3+/-5.5 days. Median follow-up was 52.0 months (range 1-109); only 1 patient was lost to follow-up. At 9 years, patient survival was 56% and freedom from secondary interventions was 48%. In 68% of cases, these reinterventions were needed for a fixation-related complication, and most of these complications (75%) encompassed the area of the proximal aneurysm neck. Primary clinical success was 37% at 9 years. After secondary interventions, the assisted primary clinical success improved to 73% at 9 years. Freedom from aneurysm-related death was 97% at 1 year and 90% at 9 years. Conclusion: As an alternative to open repair, EVAR with the AneuRx device has low perioperative mortality. Reinterventions are mostly due to fixation-related complications. While the overall mortality risk in this population was 5% per year, annual aneurysm-related death was only 1%. The focus should be on surveillance and reducing the rate of long-term complications, which might be possible with improved proximal stent-graft fixation
van Hooft JE, Bemelman WA, Breumelhof R, Siersema PD, Kruyt PM, van der Linde K, Veenendaal RA, Verhulst ML, Marinelli AW, Gerritsen JJ, van Berkel AM, Timmer R, Grubben MJ, Scholten P, Geraedts AA, Oldenburg B, Sprangers MA, Bossuyt PM, Fockens P. Colonic stenting as bridge to surgery versus emergency surgery for management of acute left-sided malignant colonic obstruction: a multicenter randomized trial (Stent-in 2 study). BMC Surgery 2007; 7:12.
Abstract: ABSTRACT: BACKGROUND: Acute left-sided colonic obstruction is most often caused by malignancy and the surgical treatment is associated with a high mortality and morbidity rate. Moreover, these operated patients end up with a temporary or permanent stoma. Initial insertion of an enteral stent to decompress the obstructed colon, allowing for surgery to be performed electively, is gaining popularity. In uncontrolled studies stent placement before elective surgery has been suggested to decrease mortality, morbidity and number of colostomies. However stent perforation can lead to peritoneal tumor spill, changing a potentially curable disease in an incurable one. Therefore it is of paramount importance to compare the outcomes of colonic stenting followed by elective surgery with emergency surgery for the management of acute left-sided malignant colonic obstruction in a randomized multicenter fashion. METHODS/DESIGN: Patients with acute left-sided malignant colonic obstruction eligible for this study will be randomized to either emergency surgery (current standard treatment) or colonic stenting as bridge to elective surgery. Outcome measurements are effectiveness and costs of both strategies. Effectiveness will be evaluated in terms of quality of life, morbidity and mortality. Quality of life will be measured with standardized questionnaires (EORTC QLQ-C30, EORTC QLQ-CR38, EQ-5D and EQ-VAS). Morbidity is defined as every event leading to hospital admission or prolonging hospital stay. Mortality will be analyzed as total mortality as well as procedure-related mortality. The total costs of treatment will be evaluated by counting volumes and calculating unit prices. Including 120 patients on a 1:1 basis will have 80% power to detect an effect size of 0.5 on the EORTC QLQ-C30 global health scale, using a two group t-test with a 0.05 two-sided significance level. Differences in quality of life and morbidity will be analyzed using mixed-models repeated measures analysis of variance. Mortality will be compared using Kaplan-Meier curves and log-rank statistics. DISCUSSION: The Stent-in 2 study is a randomized controlled multicenter trial that will provide evidence whether or not colonic stenting as bridge to surgery is to be performed in patients with acute left-sided colonic obstruction. TRIAL REGISTRATION: Current Controlled Trials ISRCTN46462267
van Kessel DA. Chirurgische behandeling. In: Boot BS, Kerstjens HAM, editors. Zorg rondom COPD. Houten: Bohn Stafleu van Loghum, 2007: 75-87.
van Keulen JK, de Kleijn DP, Oude Nijhuis MM, Busser E, Velema E, Fijnheer R, van der Graaf Y, Moll FL, de Vries JP, Pasterkamp G. Levels of extra domain A containing fibronectin in human atherosclerotic plaques are associated with a stable plaque phenotype. Atherosclerosis 2007; 195(1):e83-e91.
van Laake LW, van den Driesche S, Post S, Mager JJ, Snijder RJ, Westerman CJJ, Doevendans PA, van Echteld CJA, ten Dijke P, Arthur HM, Goumans MJ, Lebrin F, Mummery CL. Endoglin has a crucial role in blood cell-mediated vascular repair. VII International HHT scientific conference, Capri, Italy, 25-28 april 2007; Hematology Meeting Reports:1.
van Meerbeeck JP, Kramer GW, van Schil PE, Legrand C, Smit EF, Schramel F, Tjan-Heijnen VC, Biesma B, Debruyne C, van Zandwijk N, Splinter TA, Giaccone G. Randomized controlled trial of resection versus radiotherapy after induction chemotherapy in stage IIIA-N2 non-small-cell lung cancer. Journal of the National Cancer Institute 2007; 99(6):442-450.
Abstract: BACKGROUND: Induction chemotherapy before surgical resection increases survival compared with surgical resection alone in patients with stage IIIA-N2 non-small-cell lung cancer (NSCLC). We hypothesized that, following a response to induction chemotherapy, surgical resection would be superior to thoracic radiotherapy as locoregional therapy. METHODS: Selected patients with histologic or cytologic proven stage IIIA-N2 NSCLC were given three cycles of platinum-based induction chemotherapy. Responding patients were subsequently randomly assigned to surgical resection or radiotherapy. Survival curves were estimated using Kaplan-Meier analyses from time of randomization. RESULTS: Induction chemotherapy resulted in a response rate of 61% (95% confidence interval [CI] = 57% to 65%) among the 579 eligible patients. A total of 167 patients were allocated to resection and 165 to radiotherapy. Of the 154 (92%) patients who underwent surgery, 14% had an exploratory thoracotomy, 50% a radical resection, 42% a pathologic downstaging, and 5% a pathologic complete response; 4% died after surgery. Postoperative radiotherapy was administered to 62 (40%) of patients in the surgery arm. Among the 154 (93%) irradiated patients, overall compliance to the radiotherapy prescription was 55%, and grade 3/4 acute and late esophageal and pulmonary toxic effects occurred in 4% and 7%; one patient died of radiation pneumonitis. Median and 5-year overall survival for patients randomly assigned to resection versus radiotherapy were 16.4 versus 17.5 months and 15.7% versus 14%, respectively (hazard ratio = 1.06, 95% CI = 0.84 to 1.35). Rates of progression-free survival were also similar in both groups. CONCLUSION: In selected patients with pathologically proven stage IIIA-N2 NSCLC and a response to induction chemotherapy, surgical resection did not improve overall or progression-free survival compared with radiotherapy. In view of its low morbidity and mortality, radiotherapy should be considered the preferred locoregional treatment for these patients
van Meeuwen E, Batten EJ, Schepens MAAM, van Boven WJ. Chylothorax, een ernstige complicatie na thoraxchirurgie. Critical care : multidisciplinair vakblad 2007; 4(4):20-22.
van Meeuwen JA, Korthagen N, de Jong PC, Piersma AH, van den Berg M. (Anti)estrogenic effects of phytochemicals on human primary mammary fibroblasts, MCF-7 cells and their co-culture. Toxicology & Applied Pharmacology 2007; 221(3):372-383.
Abstract: In the public opinion, phytochemicals (PCs) present in the human diet are often considered beneficial (e.g. by preventing breast cancer). Two possible mechanisms that could modulate tumor growth are via interaction with the estrogen receptor (ER) and inhibition of aromatase (CYP19). Multiple in vitro studies confirmed that these compounds act estrogenic, thus potentially induce tumor growth, as well as aromatase inhibitory, thus potentially reduce tumor growth. It is thought that in the in vivo situation breast epithelial (tumor) cells communicate with surrounding connective tissue by means of cytokines, prostaglandins and estradiol forming a complex feedback mechanism. Recently our laboratory developed an in vitro co-culture model of healthy mammary fibroblasts and MCF-7 cells that (at least partly) simulated this feedback mechanism (M. Heneweer et al., TAAP vol. 202(1): 50-58, 2005). In the present study biochanin A, chrysin, naringenin, apigenin, genistein and quercetin were studied for their estrogenic properties (cell proliferation, pS2 mRNA) and aromatase inhibition in MCF-7 breast tumor cells, healthy mammary fibroblasts and their co-culture. The proliferative potency of these compounds in the MCF-7 cells derived from their EC(50)s decreased in the following order: estadiol (4*10(-3) nM)>biochanin A (9 nM)>genistein (32 nM)>testosterone (46 nM)>naringenin (287 nM)>apigenin (440 nM)>chrysin (4 microM). The potency to inhibit aromatase derived from their IC(50)s decreased in the following order: chrysin (1.5 muM)>naringenin (2.2 muM)>genistein (3.6 muM)>apigenin (4.1 muM)>biochanin A (25 muM)>quercetin (30 muM). The results of these studies show that these PCs can induce cell proliferation or inhibit aromatase in the same concentration range (1-10 muM). Results from co-cultures did not elucidate the dominant effect of these compounds. MCF-7 cell proliferation occurs at concentrations that are not uncommon in blood of individuals using food supplements. Results also indicate that estrogenicity of these PCs is quantitatively more sensitive than aromatase inhibition. It is suggested that perhaps a more cautionary approach should be taken for these PCs before taken as food supplements
van Minnen LP, Timmerman HM, Lutgendorff F, Verheem A, Harmsen W, Konstantinov SR, Smidt H, Visser MR, Rijkers GT, Gooszen HG, Akkermans LM. Modification of intestinal flora with multispecies probiotics reduces bacterial translocation and improves clinical course in a rat model of acute pancreatitis. Surgery 2007; 141(4):470-480.
Abstract: BACKGROUND: Infection of pancreatic necrosis by gut bacteria is a major cause of morbidity and mortality in patients with severe acute pancreatitis. Use of prophylactic antibiotics remains controversial. The aim of this experiment was assess if modification of intestinal flora with specifically designed multispecies probiotics reduces bacterial translocation or improves outcome in a rat model of acute pancreatitis. METHODS: Male Sprague-Dawley rats were allocated into 3 groups: (1) controls (sham-operated, no treatment), (2) pancreatitis and placebo, and (3) pancreatitis and probiotics. Acute pancreatitis was induced by intraductal glycodeoxycholate and intravenous cerulein infusion. Daily probiotics or placebo was administered intragastrically from 5 days prior until 7 days after induction of pancreatitis. Tissue and fluid samples were collected for microbiologic and quantitative real-time PCR analysis of bacterial translocation. RESULTS: Probiotics reduced duodenal bacterial overgrowth of potential pathogens (Log(10) colony-forming units [CFU]/g 5.0 +/- 0.7 [placebo] vs 3.5 +/- 0.3 CFU/g [probiotics], P < .05), resulting in reduced bacterial translocation to extraintestinal sites, including the pancreas (5.38 +/- 1.0 CFU/g [placebo] vs 3.1 +/- 0.5 CFU/g [probiotics], P < .05). Accordingly, health scores were better and late phase mortality was reduced: 27% (4/15, placebo) versus 0% (0/13, probiotics), respectively, P < .05. CONCLUSIONS: This experiment supports the hypothesis that modification of intestinal flora with multispecies probiotics results in reduced bacterial translocation, morbidity, and mortality in the course of experimental acute pancreatitis
van Moorsel CHM, van Oosterhout MFM, Ruven HJT, van den Bosch JMM, Grutters JC. The occurrence and clinical characteristics of SFTPC mutations in familial idiopathic pulmonary fibrosis. American Journal of Respiratory & Critical Care Medicine 2007; 175:A984.
van Moorsel CHM, van den Bosch JMM, Ruven HJT, Grutters JC . The occurrence of SFTPC mutations in familial idiopathic pulmonary fibrosis. Euromedlab 2007.
van Moorsel CHM, van Oosterhout MFM, van den Bosch JJM, Ruven HJT, Grutters JC. Surfactantproteïne-C-mutaties in families met idiopathische pulmonale fibrose. Nederlands Tijdschrift voor Klinische Chemie en Laboratoriumgeneeskunde 2007; 32(4):263-265.
van Oostrom AJ, Hagen EC, de Klerk JM, Schepens MA, Senden PJ, Landman MA. Steroid responsive aortitis. European Heart Journal 2007; 28(16):2005.
van Oostrom AJ, Alipour A, Plokker TW, Sniderman AD, Cabezas MC. The metabolic syndrome in relation to complement component 3 and postprandial lipemia in patients from an outpatient lipid clinic and healthy volunteers. Atherosclerosis 2007; 190(1):167-173.
Abstract: We investigated the relationship between complement component 3 (C3), fasting and postprandial lipemia and the metabolic syndrome (MetabS). Herefore fasting and postprandial samples after an acute oral fat load were obtained in 40 MetabS+ (50+/-8 years) and 70 MetabS- (48+/-7 years) subjects. Fasting C3 was higher in MetabS+ (1.21+/-0.33g/L versus 0.91+/-0.14g/L, P<0.001). Postprandially, MetabS+ had a higher total and incremental triglyceride response (TG-AUC: +77%; P<0.001 and TG-dAUC: +48%; P<0.05, respectively) and a higher total free fatty acid (FFA-AUC: +13%, P<0.05) and C3 response (C3-AUC: +26%, P<0.001) when compared to MetabS-. In both groups, fasting C3 was strongly associated with fasting TG, TG-AUC, TG-dAUC and insulin sensitivity (HOMA) (R=0.68, 0.67, 0.41 and 0.67, respectively, for the whole group; P<0.001 for each). Fasting C3 showed a dose-dependent relation with the number of MetabS components and, following exclusion of these components, it was after TG-AUC, the second best determinant of the MetabS (adjusted R(2)=0.47, P<0.001). In conclusion, C3 and postprandial lipema are closely associated with the metabolic syndrome and with several metabolic variables linked to insulin resistance. C3 may be a useful marker to identify subjects with the metabolic syndrome
van Oostrom AJHH, Alipour A, Sijmonsma TP, Verseyden C, Dallinga-Thie GM, Plokker HWM, Castro Cabezas M. Comparison of different methods to study postprandial lipemia and effects of rosuvastatin in patients with insulin resistance and premature coronary sclerosis. Atherosclerosis Supplements 2007; 8(1):207.
van Oostrom O, Nieuwdorp M, Westerweel PE, Hoefer IE, Basser R, Stroes ES, Verhaar MC. Reconstituted HDL increases circulating endothelial progenitor cells in patients with type 2 diabetes. Arteriosclerosis, Thrombosis & Vascular Biology 2007; 27(8):1864-1865.
van Os KJ, Vijverberg PLM. Transurethrale behandeling van het blaasdivertikel. Nederlands Tijdschrift voor Urologie 2007;77.
van Os KJ, van Vulpen M, Onaca MG. Recidief of PSA-bounce? Nederlands Tijdschrift voor Urologie 2007;(1):2-5.
van Putte BP, Vink A, de Bruin PC, Defauw JJ. Selective antegrade cardioplegic perfusion complicated by left main stem dissection. Journal of Cardiovascular Surgery 2007; 48(2):247-248.
Abstract: Selective antegrade coronary artery perfusion is a commonly used procedure to obtain myocardial preservation during cardiac surgery. This report describes a patient operated for severe aortic valve stenosis and insufficiency, mitral valve and tricuspid insufficiency. Cardioplegia was administered by selective antegrade coronary artery blood perfusion. Antegrade blood cardioplegia was complicated by dissection of the left coronary main stem. The dissection induced a myocardial infaction and the patient finally died due to heart failure
van Putte BP, Bollen TL, Schepens MA. Bleeding sarcoma of the aorta mimicking a symptomatic aneurysm. Journal of Thoracic & Cardiovascular Surgery 2007; 133(6):1643-1644.
van Santvoort HC, Besselink MG, Bollen TL, Buskens E, van Ramshorst B, Gooszen HG, Dutch Acute Pancreatitis Study Group. Case-matched comparison of the retroperitoneal approach with laparotomy for necrotizing pancreatitis. World Journal of Surgery 2007; 31(8):1635-1642.
Abstract: BACKGROUND: Minimally invasive necrosectomy through a retroperitoneal approach is gaining popularity for the treatment of necrotizing pancreatitis. There is, however, no substantial evidence from comparative studies in favor of this technique over laparotomy. The aim of this case-matched study was to perform the first head-to-head comparison of necrosectomy by the retroperitoneal approach with laparotomy in patients with necrotizing pancreatitis. METHODS: Between 2001 and 2005, there were 15 of 841 consecutive acute pancreatitis patients who underwent necrosectomy by the retroperitoneal approach using a small flank incision. These patients were matched for the presence of preoperative organ failure, status of infection, timing of surgery, age, and computed tomography severity index score with 15 of 46 patients treated with necrosectomy by laparotomy and continuous postoperative lavage (CPL). METHODS: In addition to all matched preoperative characteristics, there were no significant differences in sex, preoperative intensive care unit (ICU) admission, preoperative ICU stay, preoperative APACHE-II scores, and preoperative multiple organ failure (MOF). Postoperative complications requiring reintervention occurred in six patients in each group (p = 1.000). Postoperative new-onset MOF occurred in 10 patients in the laparotomy/CPL group versus 2 patients in the retroperitoneal approach group (p = 0.008). Six patients died in the laparotomy/CPL group versus 1 patient in the retroperitoneal approach group (p = 0.080). CONCLUSIONS: The less postoperative organ failure and the trend toward lower mortality may point to a benefit of the retroperitoneal approach over laparotomy. A randomized controlled design is, however, still required to answer definitively the question of which operative technique is preferably for patients with (infected) necrotizing pancreatitis
van Santvoort HC, Besselink MGH, Horvath KD, Sinanan MN, Bollen TL, van Ramshorst B, Gooszen HG, for the Dutch Acute Pancreatitis Study Group. Videoscopic assisted retroperitoneal debridement in infected necrotizing pancreatitis. HPB : the official journal of the International Hepato Pancreato Biliary Association 2007; 9(2):156-159.
van Strijen M. Diagnosing pulmonary embolism : establishing and consolidating the role of spiral CT. s.l.: s.n., 2007.
van Tuyl SA, Letteboer TG, Rogge-Wolf C, Kuipers EJ, Snijder RJ, Westermann CJ, Stolk MF. Assessment of intestinal vascular malformations in patients with hereditary hemorrhagic teleangiectasia and anemia. European Journal of Gastroenterology & Hepatology 2007; 19(2):153-158.
Abstract: INTRODUCTION: Hereditary hemorrhagic teleangiectasia (HHT) is an autosomal dominant disorder with mucocutaneous teleangiectasia and visceral arteriovenous malformations. Mutations of endoglin and Activin A receptor like kinase-1 have different phenotypes, HHT1 and HHT2, respectively. The gastrointestinal tract is frequently affected, but limited information is available on the relationship with genotype. AIM: To determine whether different genotypes have different phenotypes with respect to intestinal teleangiectasia. METHODS: HHT patients, referred for anemia, underwent videocapsule endoscopy. Chart review was performed for information on genotype and HHT manifestations. RESULTS: Twenty-five patients were analyzed (men/women 13/9, mean age 49+/-15 years.), 14 HHT1, eight HHT2 and three without known mutation. Epistaxis occurred in 96% of patients. Gastroduodenoscopy revealed teleangiectasia in 7/12 (58%) HHT1 and 3/8 (38%) HHT2 patients. Videocapsule endoscopy found teleangiectasia in all HHT1 and 5/8 (63%) HHT2 patients. In 9/14 HHT1 patients, teleangiectasia were large. Teleangiectasia in the colon was restricted to 6/11 (55%) HHT1 patients. Hepatic arteriovenous malformations were present in 1/7 HHT1 and 5/6 HHT2 patients. CONCLUSION: Large teleangiectasia in small intestine and colon appear to occur predominantly in HHT1. Hepatic arteriovenous malformations are mainly found in HHT2. In HHT patients with unexplained anemia, videocapsule endoscopy should be considered to determine the size and extent of teleangiectasia and exclude other abnormalities
van Tuyl SA, Tenthof van Noorden J, Stolk MF, Kuipers EJ. Clinical consequences of videocapsule endoscopy in GI bleeding and Crohn's disease. Gastrointestinal Endoscopy 2007; 66(6):1164-1170.
Abstract: BACKGROUND: Videocapsule endoscopy (VCE) has a high diagnostic yield in the analysis of GI bleeding and Crohn's disease. Little information is available on the impact of VCE findings on clinical care. OBJECTIVE: Assess the impact of VCE findings on clinical management and outcome. DESIGN: Retrospective descriptive study. SETTING: General hospital. PATIENTS: VCE was performed in 150 patients for GI bleeding (n = 97), Crohn's disease (n = 36), and miscellaneous reasons (n = 17). MAIN OUTCOME MEASUREMENTS: Clinical consequences were evaluated by using a questionnaire and were divided into change of management or unchanged management. Change of medication, endoscopic procedures, surgical procedures, other consequences, and avoidance of additional investigations were considered a change of management. For all patients, an assessment of the actual clinical condition and the most recent Hb level were registered. RESULTS: A definite diagnosis was established in 34%, a probable diagnosis in 34%, and no diagnosis in 32%. Management was changed in 38% of patients, increasing to 59% if a definite diagnosis was established at VCE. No relation between change of management and clinical improvement or increased Hb level could be established. LIMITATIONS: The start of ethinylestradiol/norethisterone in case of telangiectasia was considered a change of management, although controversy on the rationale of this treatment exists. A more detailed and objective evaluation of the clinical condition should be performed to assess the clinical outcome. CONCLUSIONS: VCE findings have a serious impact on clinical practice. VCE in particular leads to a change of management in 59% of the patients in whom a definite diagnosis is established
van Tuyl SA, den Ouden H, Stolk MF, Kuipers EJ. Optimal preparation for video capsule endoscopy: a prospective, randomized, single-blind study. Endoscopy 2007; 39(12):1037-1040.
Abstract: BACKGROUND AND STUDY AIM: Visualization of the small bowel by video capsule endoscopy (VCE) is frequently impaired by intestinal contents. Different bowel preparations have been studied with controversial results. The aim of this study was to determine a satisfactory and tolerable bowel preparation for VCE. METHODS: Ninety patients were randomized to three preparation regimens. Group A underwent VCE after clear liquid diet and overnight fast, while groups B and C received respectively 1 or 2 L of polyethylene glycol (PEG) solution before VCE. For each VCE five segments of 10 minutes were selected, one at the start of each quartile of the small-intestinal transit time, the fifth being the last 10 minutes of the ileum transit. Mucosal visibility was regarded as good if more than 75 % of the mucosa could be evaluated. All patients answered a questionnaire regarding procedure tolerability. RESULTS: The use of PEG solution led to a significant improvement in mucosal visualization. Mucosal visibility was good in the terminal ileum in 25 % of patients in group A, 52 % in group B, and 72 % in group C. The diagnostic yield did not change significantly. The use of 2 L of PEG solution was considered more uncomfortable than no PEG solution or 1 L of the same. CONCLUSION: One liter of PEG solution improves mucosal visualization without causing discomfort for the patient
van Tuyl SAC. Videocapsule Endoscopy : Fiction becoming fact. Enschede: Gildeprint drukkerijen, 2007.
van Vliet-van Wensen A. Slecht nieuws: een goed gesprek? 2007.
van Vliet A. Slecht nieuws: een goed gesprek? Patiënttevredenheid over de procedure van het geven van slecht nieuws aan mammacarcinoom patiënten die behandeld worden met adjuvante chemotherapie op de Interne poli van het St. Antonius Ziekenhuis te Nieuwegein. Tilburg: MANP Fontys Hogescholen, 2007.
van Werkum JW, van der Stelt CA, Seesing TH, ten Berg JM, Hackeng CM. The flow cytometric VASP-assay can be used to determine the effectiveness of clopidogrel in patients treated with abciximab. Journal of Thrombosis & Haemostasis 2007; 5(4):881-883.
van Werkum JW, Seesing TH, Suttorp MJ, Bal ET, den Heijer P, ten Berg JM. Double-trouble: three cases with simultaneous stent thrombosis in different coronary arteries. Journal of Interventional Cardiology 2007; 20(2):132-135.
Abstract: We report about three cases with a unique simultaneous double- trouble stent thrombosis in different coronary arteries. Although the triggering mechanism remains purely speculative, it is possible that suboptimal stent size and perhaps underexpansion caused the stent thrombosis in one stent resulting in a heightened platelet activation and impaired hemodynamics causing the second stent thrombosis
van Werkum JW, ten Berg JM, Plokker THW, Kelder JC, Suttorp MJ, Rensing BJ, Tersmette M. Staphylococcus aureus infection complicating percutaneous coronary interventions. International Journal of Cardiology 2007; [Epub ahead of print].
Abstract: BACKGROUND: This study sought to determine the incidence, risk factors, and characteristics of Staphylococcus (S.) aureus infections complicating percutaneous coronary interventions (PCI). METHODS: Between January 1999 and December 2002, 7640 PCI's were evaluated from 1 to 16 days post-PCI for the occurrence of a documented S. aureus infection. A case-control study was used to identify risk factors for the development of S. aureus infection in patients undergoing PCI. RESULTS: In total 21 S. aureus infections (0.27%) were documented at 1 to 16 days after the index PCI. The overall incidence of PCI-related infection was 0.14% (11 cases), 0.13% (10 cases) were intravascular line related. All 21 cases with S. aureus infections were matched with 63 controls randomly selected among patients who underwent a PCI but did not have S. aureus infections. Among the patients with S. aureus infections, the duration of hospital stay was significantly increased (24 vs 5 days). The overall mortality rate in the 21 patients with S. aureus infections was 4/21 [19%] (controls 2/42 [3%]). Congestive heart failure, alcohol abuse, emergency PCI, more than 1 PCI in three months and the presence of a sheath in the femoral artery and/or vein for the duration of more than 1 day after the procedure were independent risk factors for S. aureus infection after PCI. CONCLUSIONS: S. aureus infection is a rare but potentially serious complication of PCI. Additional precautions should be considered in patients with these risk factors
van Werkum JW, Gerritsen WB, Kelder JC, Hackeng CM, Ernst SM, Deneer VH, Suttorp MJ, Rensing BJ, Plokker HW, ten Berg JM. Inhibition of platelet function by abciximab or high-dose tirofiban in patients with STEMI undergoing primary PCI: a randomised trial. Netherlands Heart Journal 2007; 15(11):375-381.
Abstract: BACKGROUND: In patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary PCI, few data exist on the magnitude of platelet activation, aggregation and dosing of glycoprotein (GP) IIb/IIIa receptor inhibitors. METHODS : Sixty STEMI patients were randomised to abciximab, to high-dose tirofiban or to no additional GP IIb/IIIa inhibitor treatment. Platelet activation (P-selectin expression) was measured using flow cytometry and the level of inhibition of platelet aggregation was assessed using the Plateletworks assay. Additionally, the PFA-100 with the collagen/adenosine-diphosphate cartridge (CADP) was used to compare the levels of platelet inhibition. All measurements were performed at baseline (T(0)), immediately after (T(1)), 30 minutes (T(2)), 60 minutes (T(3)) and 120 minutes (T(4)) after primary PCI. RESULTS : The level of platelet activation in both GP IIb/IIIa receptor inhibitor treated groups was significantly lower compared with the control group at all time points after primary PCI (p=0.04). Also the administration of the currently recommended dose of abciximab resulted in significantly lower levels of inhibition of aggregation compared with high-dose tirofiban (p<0.0001). In addition, the CADP closure times were significantly prolonged in both GP IIb/IIIa inhibitor treated groups compared with the control group at time points T(1) (p=0.006) and T(4) (p<0.0001). CONCLUSION : The administration of high-dose tirofiban resulted in a significantly higher inhibition of platelet aggregation compared with the currently recommended dose of abciximab. Large clinical trials are needed to assess whether this laboratory superiority of high-dose tirofiban translates into higher clinical efficacy. (Neth Heart J 2007;15:375-81.)
van Werkum JW, ten Berg JM, Rechner AR, de Haan J, Hackeng CM. Comparison of a new cartridge* for the pfa-100® with other platelet function assays for measuring the effect of clopidogrel therapy in cardiovascular patients. Journal of Thrombosis & Haemostasis 2007; 5(Suppl 2):P-T-362.
van Werkum JW, Hackeng CM, de Korte FI, Verheugt FWA, ten Berg JM. Point-of-care platelet function testing in patients undergoing PCI: between a rock and a hard place. Netherlands Heart Journal 2007; 15(9):299-305.
van Werkum JW, Heestermans AA, Plokker HW, ten Berg JM. Clinical, biochemical and genetical resistance to clopidogrel in a patient with recurrent stent thrombosis. International Journal of Cardiology 2007; 116(1):136-137.
van Werkum JW, Heestermans AACM, Taubert D, von Beckerath N, Seesing TH, Hackeng CM, ten Berg JM. Impaired efficacy of clopidogrel in patients with a ST-segment elevation myocardial infarction. Journal of Thrombosis & Haemostasis 2007; 5(Suppl 2):P-W-279.
van Werkum JW, Kleibeuker M, Mieremet N, ten Berg JM, Hackeng CM. Evaluation of the platelet response to clopidogrel with light transmittance aggregometry: peak aggregation or late aggregation? Journal of Thrombosis & Haemostasis 2007; 5(4):884-886.
van Zandwijk N, Hoogsteden HC, van den Bosch JMM. Neoplasmata van de longen, de pleura en het mediastinum. In: van den Bosch JMM, Bottema BJAM, Lammers J-WJ, Zaagsma J, editors. Het pulmonaal formularium : een praktische leidraad. Houten: Bohn Stafleu Van Loghum, 2007: 130-143.
Veersema S. Pelvic X Ray is Insufficient for the 3 Month Follow-up of Essure Sterilization. Journal of Minimally Invasive Gynecology 2007; 14(6 suppl 1):s102-s103.
Veldman-Ariesen MJ, de Jongh BM, Schneeberger PM, van Zeijl JH. Antibiotic resistance of Pseudomonas aeruginosa and seasonal differences in positive cultures results from a laboratory surveillance study (ISIS) in the Netherlands: an overview of 2001-2005. Nederlands Tijdschrift voor Medische Microbiologie 2007; 15(Suppl):P036.
Veltkamp M, Grutters JC, van Moorsel CH, Rijkers GT, Ruven HJ, Drent M, van den Bosch JM. CD14 genetics in sarcoidosis patients; who's in control? Sarcoidosis Vasculitis & Diffuse Lung Diseases 2007; 24(2):154-155.
Veltkamp M, Wijnen PA, van Moorsel CH, Rijkers GT, Ruven HJ, Heron M, Bekers O, Claessen AM, Drent M, van den Bosch JM, Grutters JC. Linkage between Toll-like receptor (TLR) 2 promotor and intron polymorphisms: functional effects and relevance to sarcoidosis. Clinical & Experimental Immunology 2007; 149(3):453-462.
Abstract: The intracellular pathogens Propionibacterium acnes and Mycobacterium tuberculosis have been leading suspects as the cause of sarcoidosis, a systemic disorder characterized by the formation of non-caseating granulomas. Toll-like receptor (TLR) 2 is important in the innate immune response against both pathogens, and is therefore of interest in sarcoidosis research. In the present study, three single nucleotide polymorphisms and one dinucleotide repeat polymorphism in the TLR-2 gene were genotyped in 419 sarcoidosis patients, divided into a study cohort and a validation cohort, and 196 healthy controls. In the study cohort we found a significant increase in prevalence of the AA-genotype at promotor location -16934 in patients with chronic disease compared to patients with acute/self-remitting sarcoidosis (34.5% versus 15.9%, respectively, P = 0.006, P(c) = 0.019). These results could not be confirmed in our validation cohort, implicating a possible role for TLR-2 genetics in only a small percentage of sarcoidosis patients. Furthermore, linkage was found between the promotor polymorphism -16934 A/T and the number of GT repeats in intron 1 (P < 0.0001). After in vitro stimulation of peripheral blood mononuclear cells (PMBCs) with different TLR-2 agonists, a correlation between induction of TNF-alpha (P = 0.008), interleukin (IL)-12 (P = 0.008) as well as IL-6 (P = 0.02), and the number of GT repeats was observed. In conclusion, the data show that polymorphisms in TLR-2 might be important in a small group of sarcoidosis patients and that their functional consequences explain partly some of the variance in cytokine pattern observed in different clinical phenotypes of this disease
Venhuizen AC, Hustinx WNM, van Houte AJ, Veth G, van der Griend R. Three cases of Pneumocystis carinii pneumonia during first-time treatment with rituximab in combination with CHOP for agressive B-cell non-Hodgkin's lymphoma. 19e Internistendagen : abstractboek :25, 26 & 27 april 2007 MECC Maastricht 2007;44-45.
Verbeek WHM, Al-Toma A, Oudejans JJ, Mulder CJJ. The incidence of Enteropathy Associated T–cell Lymphoma: a nation-wide study of a population-based registry in the Netherlands. DDW Washington 2007;A-667.
Verburg FA, Backus B, Romijn RL, Kruitwagen CLJJ, Konijnenberg MW, Beekman FJ, van Rijk PP, Verzijlbergen FJ. Towards simultaneous dual isotope myocardial SPECT: intra-patient reproducibility of myocardial SPECT imaging with Tl-201 and Tc-99m-sestamibi. European Journal of Nuclear Medicine & Molecular Imaging 2007; 34(Suppl 2):S273.
Verburg FA, Romijn RL, Cramer MJM, Verzijlbergen JF. Quantitative comparison of repeated SPECT scans using a novel 68-segment model. European Journal of Nuclear Medicine & Molecular Imaging 2007; 34(Suppl 2):S273.
Vernooij CM, Hogeman PH, Nikkels PG, Blok CA, Brouwers HA. Necrosis of the left buttock as a complication of umbilical catheterisation in neonatal resuscitation. Archives of Disease in Childhood Fetal & Neonatal Edition 2007; 92(1):F48.
Verrij EA, Meinders AJ, Biesma DH. Stroop door de scoop. 1e Ned Hematologie Congres, Arnhem, 1-2 feb 2007.
Verrij EA, Slee PHThJ. A chlorthalidone induced hyperosmolar, hyperglycaemic, nonketotic coma. 19e Internistendagen : abstractboek :25, 26 & 27 april 2007 MECC Maastricht 2007;59.
Verrij EA, Bos WJ. The effect of raising the forearm on the loudness of the Korotkoff sounds. 19e Internistendagen : abstractboek :25, 26 & 27 april 2007 MECC Maastricht 2007;83-84.
Verrij EA, Biesma DH, Ozdemir A, Meinders A-J. Visualization of microvascular blood flow in extreme leukocytosis. 19e Internistendagen : abstractboek :25, 26 & 27 april 2007 MECC Maastricht 2007;88.
Verrij EA, Wassink AMJ, Deneer VHM, de Weerdt O, Geers ABM . Treatment of metformin-induced lactic acidosis. Netherlands Journal of Critical Care 2007; 11(6):305-307.
Verstappen SM, Jacobs JW, van der Veen MJ, Heurkens AH, Schenk Y, ter Borg EJ, Blaauw AA, Bijlsma JW, on the behalf of the Utrecht Rheumatoid Arthritis Cohort study group. Intensive treatment with methotrexate in early rheumatoid arthritis: aiming for remission. Computer Assisted Management in Early Rheumatoid Arthritis (CAMERA, an open-label strategy trial). Annals of the Rheumatic Diseases 2007; 66(11):1443-1449.
Abstract: BACKGROUND: To investigate whether intensive treatment with methotrexate (MTX) according to a strict protocol and a computerised decision program is more beneficial compared to conventional treatment with MTX in early rheumatoid arthritis. METHODS: In a two-year multicentre open label strategy trial, 299 patients with early rheumatoid arthritis were randomly assigned to the intensive strategy group or the conventional strategy group. Patients in both groups received MTX, the aim of treatment being remission. Patients in the intensive treatment group came to the outpatient clinic once every month; adjustment of the MTX dosage was tailored to the individual patient on the basis of predefined response criteria, using a computerised decision program. Patients of the conventional strategy group came to the outpatient clinic once every three months; they were treated according to common practice. Cyclosporine was added if patients had an inadequate response to maximal tolerated MTX doses. RESULTS: Seventy six (50%) patients in the intensive strategy group achieved at least one period of remission during the two year trial, versus 55 patients (37%) in the conventional strategy group (p = 0.03). Areas under the curve for nearly all clinical variables were significantly lower-that is, there was a better clinical effect for the intensive treatment group compared with the conventional treatment group. CONCLUSION: The results of this study show that it is possible to substantially enhance the clinical efficacy early in the course of the disease by intensifying treatment with MTX, aiming for remission, tailored to the individual patient. Furthermore, participating rheumatologists indicated that the computerised decision program could be a helpful tool in their daily clinical practice
Verzijlbergen JF. The white paper. Tijdschrift voor Nucleaire Geneeskunde 2007; 29(3):120-121.
Verzijlbergen JF, Keijsers RG, Grutters JC, Lavalaye J, Tiel-van Buul M, van den Bosch JM. A novel classification of sarcoidosis base don 18FDG-PET. American Journal of Respiratory & Critical Care Medicine 2007; 175:A362.
Vidakovic M, Slee PHThJ. Is endoscopisch onderzoek vereist bij de diagnostiek van ferriprieve anemie bij premenopauzale vrouwen? Internisten Vademecum 2007; 13(5).
Vidakovic M, Biemond-Moeniralam HS, Kuypers KC. Malignant emboli. 19e Internistendagen : abstractboek :25, 26 & 27 april 2007 MECC Maastricht 2007;81.
Vigt AB, Kramer WLM, Besselaar PP, Hammacher ER. Onderbeenfracturen. In: Kramer WLM, ten Duis HJ, Ekkelkamp S, Kimpen JLL, Leenen LPH, Patka P, editors. Handboek kindertraumatologie. Utrecht: De Tijdstroom, 2007: 647-662.
Visser LE, Rettig MT, Kyei-Faried S, Geelhoed DW, Schagen van Leeuwen J, van Roosmalen J. Successful reduction of anaemia deaths in children in a rural hospital in Ghana. Tropical Medicine & International Health 2007; 12(Suppl 1):68.
Visser N, van Rijn BB, Rijkers GT, Franx A, Bruinse HW. Inflammatory changes in preeclampsia: current understanding of the maternal innate and adaptive immune response. Obstetrical & gynecological survey 2007; 62(3):191-201.
Abstract: Preeclampsia is characterized by generalized endothelial dysfunction as a result of an inappropriate maternal immune response against the fetus. It has been postulated that the adaptive immune system plays a key role in the etiology of preeclampsia by generating a pro-inflammatory Th1 type immune reaction. In this review, recent studies on Th1 and Th2 type cytokine mapping in preeclampsia are reviewed, as well as on the sources of pro-inflammatory cytokines and the role of regulatory cytokines and chemokines. In addition, we discuss the possible role of Toll-like receptors of the innate immune system in the pathophysiology of preeclampsia. TARGET AUDIENCE: Obstetricians & Gynecologists, Family Physicians. LEARNING OBJECTIVES: After completion of this article, the reader should be able to summarize the newer concepts related to the pathogenesis of preeclampsia and explain the role of the maternal immune system and the role of pro-inflammatory and regulatory cytokines and chemokines in the pathophysiology of the disease
Visser OJ, Al-Toma A. Refractaire coeliakie en de ontwikkeling van T-cel-non-Hodgkinlymfoom in de darm: kliniek, diagnostiek en behandelingsmogelijkheden. Oncollectie 2007; 1:1-8.
Vlaminckx BJ, Schuren FH, Montijn RC, Caspers MP, Beitsma MM, Wannet WJ, Schouls LM, Verhoef J, Jansen WT. Dynamics in Prophage Content of Invasive and Noninvasive M1 and M28 Streptococcus pyogenes Isolates in The Netherlands from 1959 to 1996. Infection & Immunity 2007; 75(7):3673-3679.
Abstract: Invasive group A streptococcal (GAS) disease reemerged in The Netherlands in the late 1980s. To seek an explanation for this resurgence, the genetic compositions of 22 M1 and 19 M28 GAS strains isolated in The Netherlands between 1960s and the mid-1990s were analyzed by using a mixed-genome DNA microarray. During this four-decade period, M1 and especially M28 strains acquired prophages on at least eight occasions. All prophages carried a superantigen (speA2, speC, speK) or a streptodornase (sdaD2, sdn), both associated with invasive GAS disease. Invasive and noninvasive GAS strains did not differ in prophage acquisition, suggesting that there was an overall increase in the pathogenicity of M1 and M28 strains over the last four decades rather than emergence of hypervirulent subclones. The increased overall pathogenic potential may have contributed to the reemergence of invasive GAS disease in The Netherlands
Vlaminckx BJ, Mascini EM, Schellekens JF. Invasieve infecties met streptokokken uit lancefield-groep A in Nederland. Nederlands Tijdschrift voor Geneeskunde 2007; 151(30):1669-1673.
Vlaminckx BJ, Schuren FH, Montijn RC, Caspers MP, Fluit AC, Wannet WJ, Schouls LM, Verhoef J, Jansen WT. Determination of the relationship between group A streptococcal genome content, M type, and toxic shock syndrome by a mixed genome microarray. Infection & Immunity 2007; 75(5):2603-2611.
Abstract: Group A streptococci (GAS), or Streptococcus pyogenes, are associated with a remarkable variety of diseases, ranging from superficial infections to life-threatening diseases such as toxic-shock-like syndrome (TSS). GAS strains belonging to M types M1 and M3 are associated with TSS. This study aims to obtain insight into the gene profiles underlying different M types and disease manifestations. Genomic differences between 76 clinically well characterized GAS strains collected in The Netherlands were examined using a mixed-genome microarray. Inter-M-type genomic differences clearly outweighed intra-M-type genome variation. Phages were major contributors to observed genome diversification. We identified four novel genes, including two genes encoding fibronectin-binding-like proteins, which are highly specific to a subset of M types and thus may contribute to M-type-associated disease manifestations. All M12 strains were characterized by the unique absence of the citrate lyase complex and reduced growth under hypoxic, nutrient-deprived conditions. Furthermore, six virulence factors, including genes encoding a complement-inhibiting protein (sic), an exotoxin (speA), iron(III) binding factor, collagen binding factor (cpa), and fibrinogen binding factor (prt2-like), were unique to M1 and/or M3 strains. These virulence factors may contribute to the potential of these strains to cause TSS. Finally, in contrast to M-type-specific virulence profiles, we did not identify a common virulence profile among strains associated with TSS irrespective of their M type
Vlaminckx BJ, Boucher CA. Hiv moet meldingsplichtig worden. Nederlands Tijdschrift voor Geneeskunde 2007; 151(48):2672.
Abstract: In recent years, it has become evident that primary HIV infections are largely responsible for new cases. In order to identify the chains of transmission involved, HIV should become a notifiable disease in the Netherlands
Vlieger AM. Discussing complementary and alternative medicine use for children. Patient Education & Counseling 2007; 68(1):1-2.
Vlieger AM, Menko-Frankenhuis C, Wolfkamp SC, Tromp E, Benninga MA. Hypnotherapy for children with functional abdominal pain or irritable bowel syndrome: a randomized controlled trial. Gastroenterology 2007; 133(5):1430-1436.
Abstract: Background & Aims: Functional abdominal pain (FAP) and irritable bowel syndrome (IBS) are highly prevalent in childhood. A substantial proportion of patients continues to experience long-lasting symptoms. Gut-directed hypnotherapy (HT) has been shown to be highly effective in the treatment of adult IBS patients. We undertook a randomized controlled trial and compared clinical effectiveness of HT with standard medical therapy (SMT) in children with FAP or IBS. Methods: Fifty-three pediatric patients, age 8-18 years, with FAP (n = 31) or IBS (n = 22), were randomized to either HT or SMT. Hypnotherapy consisted of 6 sessions over a 3-month period. Patients in the SMT group received standard medical care and 6 sessions of supportive therapy. Pain intensity, pain frequency, and associated symptoms were scored in weekly standardized abdominal pain diaries at baseline, during therapy, and 6 and 12 months after therapy. Results: Pain scores decreased significantly in both groups: from baseline to 1 year follow-up, pain intensity scores decreased in the HT group from 13.5 to 1.3 and in the SMT group from 14.1 to 8.0. Pain frequency scores decreased from 13.5 to 1.1 in the HT group and from 14.4 to 9.3 in the SMT group. Hypnotherapy was highly superior, with a significantly greater reduction in pain scores compared with SMT (P < .001). At 1 year follow-up, successful treatment was accomplished in 85% of the HT group and 25% of the SMT group (P < .001). Conclusions: Gut-directed HT is highly effective in the treatment of children with longstanding FAP or IBS
Vogten JM, Overtoom TTC, Lely RJ, Quispel R, de Vries JP. Superselective Coil Embolization of Arterial Esophageal Hemorrhage. Journal of Vascular & Interventional Radiology 2007; 18(6):771-773.
Abstract: The authors report a case of arterial esophageal bleeding resistant to endoscopic hemostasis in a patient in critical condition after complicated gastrointestinal and pulmonary surgery. Unfit for surgery, the patient's massive hemorrhage was successfully treated with superselective coil embolization of the afferent esophageal branch of the thoracic aorta. In patients with severe arterial bleeding of the esophagus, percutaneous superselective arterial coil embolization may be feasible for control of hemorrhage
Vos JA. Femoral Artery Closure devices. Edurad 2007;(58).
Vos JA. Van het bestuur: Prestatie-indicatoren. Memorad 2007; 12(3):5.
Vos JA, Kolkman S, Kool DR, ter Rahe BSM, vd Woude HJ. Van het bestuur: Vooraankondiging Radiologendagen. Memorad 2007; 12(1):6.
Vos JA. Van het bestuur: De Radiologendagen: die mag je niet missen! Evaluatie Radiologendagen 2007, 'de Doelen' Rotterdam. Memorad 2007; 12(4):5-6.
Vrieling A, Voskuil DW, Bonfrer JM, Korse CM, van Doorn J, Cats A, Depla AC, Timmer R, Witteman BJ, van Leeuwen FE, van't Veer LJ, Rookus MA, Kampman E. Lycopene supplementation elevates circulating insulin-like growth factor binding protein-1 and -2 concentrations in persons at greater risk of colorectal cancer. American Journal of Clinical Nutrition 2007; 86(5):1456-1462.
Abstract: Background: Higher circulating insulin-like growth factor I (IGF-I) concentrations have been related to a greater risk of cancer. Lycopene intake is inversely associated with cancer risk, and experimental studies have shown that it may affect the IGF system, possibly through an effect on IGF-binding proteins (IGFBPs). Objective: The objective of our study was to investigate the effect of an 8-wk supplementation with tomato-derived lycopene (30 mg/d) on serum concentrations of total IGF-I, IGF-II, IGFBP-1, IGFBP-2, and IGFBP-3. Design: We conducted a randomized, placebo-controlled, double-blinded crossover study in 40 men and 31 postmenopausal women with a family history of colorectal cancer, a personal history of colorectal adenoma, or both. Results: Lycopene supplementation significantly (P = 0.01) increased serum IGFBP-1 concentrations in women (median relative difference between serum IGFBP-1 concentrations after lycopene supplementation and after placebo, 21.7%). Serum IGFBP-2 concentrations were higher in both men and women after lycopene supplementation than after placebo, but to a lesser extent (mean relative difference 8.2%; 95% CI: 0.7%, 15.6% in men and 7.8%; 95% CI: 5.0%, 20.6% in women). Total IGF-I, IGF-II, and IGFBP-3 concentrations were not significantly altered by lycopene supplementation. Conclusions: This is the first study known to show that lycopene supplementation may increase circulating IGFBP-1 and IGFBP-2 concentrations. Because of high interindividual variations in IGFBP-1 and IGFBP-2 effects, these results should be confirmed in larger randomized intervention studies
Waasdorp E, Van't Hullenaar C, van Herwaarden J, Kelder H, van de Pavoordt E, Overtoom T, Moll F, de Vries J. Renal Function After Endovascular Aortic Aneurysm Repair: A Single-center Experience with Transrenal Versus Infrarenal Fixation. Journal of Endovascular Therapy 2007; 14(2):130-137.
Abstract: Purpose: To describe the short-term consequences of endovascular aortic aneurysm repair (EVAR) on renal function after infrarenal (IR) versus transrenal (TR) stent-graft fixation. Methods: Between December 1996 and January 2006, 369 consecutive patients were treated with EVAR. All patients had an AneuRx or a Talent stent-graft implanted using IR (AneuRx) or transrenal (Talent) fixation. Post-EVAR, a standardized follow-up scheme included computed tomography (CT) scanning and serum creatinine measurements at 2 days, 3 months, and 12 months. Postoperative renal dysfunction was defined as a >20% decrease in serum creatinine clearance compared to baseline, the presence of new-onset dialysis, or both. Of the 369 patients, 309 (291 men; mean age 71+/-7 years, range 63-82) had complete 1-year follow-up and were included in this study. An IR stent-graft was placed in 190 patients, and a TR stent-graft was placed in the remaining 119 patients. Results: At discharge, renal dysfunction occurred in 3.7% of the patients in the IR group versus 5.9% in the TR group (p = NS) and rose significantly to 13.7% in the IR group (p = 0.001) and 15.1% in the TR group (p = 0.02) at the 1-year follow-up. However, no significant difference was noted between the IR and TR groups at either time point. At the 1-year follow-up, at least 50% of renal dysfunction was caused by obstructions of (accessory) renal arteries and renal infarctions. During the follow-up interval, 3 (0.97%) of 309 patients underwent new-onset dialysis. Conclusion: Both infrarenal and transrenal fixation techniques in EVAR will lead to a significant rise in renal dysfunction during the first year. A few patients with dysfunction will require dialysis
Wesselink RMJ. De pulmonaal belaste patiënt. In: Hennis PJ, Leusink JA, editors. Anesthesiologie. Houten: Bohn Stafleu Van Loghum, 2007: 237-246.
Westerhof BE, Guelen I, Stok WJ, Wesseling KH, Spaan JA, Westerhof N, Bos WJ, Stergiopulos N. Arterial pressure transfer characteristics: effects of travel time. American Journal of Physiology - Heart & Circulatory Physiology 2007; 292(2):H800-H807.
Abstract: We investigated the quantitative contribution of all local conduit arterial, blood, and distal load properties to the pressure transfer function from brachial artery to aorta. The model was based on anatomical data, Young's modulus, wall viscosity, blood viscosity, and blood density. A three-element windkessel represented the distal arterial tree. Sensitivity analysis was performed in terms of frequency and magnitude of the peak of the transfer function and in terms of systolic, diastolic, and pulse pressure in the aorta. The root mean square error (RMSE) described the accuracy in wave-shape prediction. The percent change of these variables for a 25% alteration of each of the model parameters was calculated. Vessel length and diameter are found to be the most important parameters determining pressure transfer. Systolic and diastolic pressure changed <3% and RMSE <1.8 mmHg for a 25% change in vessel length and diameter. To investigate how arterial tapering influences the pressure transfer, a single uniform lossless tube was modeled. This simplification introduced only small errors in systolic and diastolic pressures (1% and 0%, respectively), and wave shape was less well described (RMSE, approximately 2.1 mmHg). Local (arm) vasodilation affects the transfer function little, because it has limited effect on the reflection coefficient. Since vessel length and diameter translate into travel time, this parameter can describe the transfer accurately. We suggest that with a, preferably, noninvasively measured travel time, an accurate individualized description of pressure transfer can be obtained
Westerhuis ME, Moons KG, van Beek E, Bijvoet SM, Drogtrop AP, van Geijn HP, van Lith JM, Mol BW, Nijhuis JG, Oei SG, Porath MM, Rijnders RJ, Schuitemaker NW, van der Tweel I, Visser GH, Willekes C, Kwee A. A randomised clinical trial on cardiotocography plus fetal blood sampling versus cardiotocography plus ST-analysis of the fetal electrocardiogram (STAN) for intrapartum monitoring. BMC Pregnancy & Childbirth 2007; 7:13.
Abstract: BACKGROUND: Cardiotocography (CTG) is worldwide the method for fetal surveillance during labour. However, CTG alone shows many false positive test results and without fetal blood sampling (FBS), it results in an increase in operative deliveries without improvement of fetal outcome. FBS requires additional expertise, is invasive and has often to be repeated during labour. Two clinical trials have shown that a combination of CTG and ST-analysis of the fetal electrocardiogram (ECG) reduces the rates of metabolic acidosis and instrumental delivery. However, in both trials FBS was still performed in the ST-analysis arm, and it is therefore still unknown if the observed results were indeed due to the ST-analysis or to the use of FBS in combination with ST-analysis. METHODS/DESIGN: We aim to evaluate the effectiveness of non-invasive monitoring (CTG + ST-analysis) as compared to normal care (CTG + FBS), in a multicentre randomised clinical trial setting. Secondary aims are: 1) to judge whether ST-analysis of fetal electrocardiogram can significantly decrease frequency of performance of FBS or even replace it; 2) perform a cost analysis to establish the economic impact of the two treatment options.Women in labour with a gestational age > or = 36 weeks and an indication for CTG-monitoring can be included in the trial.Eligible women will be randomised for fetal surveillance with CTG and, if necessary, FBS or CTG combined with ST-analysis of the fetal ECG.The primary outcome of the study is the incidence of serious metabolic acidosis (defined as pH < 7.05 and Bdecf > 12 mmol/L in the umbilical cord artery). Secondary outcome measures are: instrumental delivery, neonatal outcome (Apgar score, admission to a neonatal ward), incidence of performance of FBS in both arms and cost-effectiveness of both monitoring strategies across hospitals.The analysis will follow the intention to treat principle. The incidence of metabolic acidosis will be compared across both groups. Assuming a reduction of metabolic acidosis from 3.5% to 2.1 %, using a two-sided test with an alpha of 0.05 and a power of 0.80, in favour of CTG plus ST-analysis, about 5100 women have to be randomised. Furthermore, the cost-effectiveness of CTG and ST-analysis as compared to CTG and FBS will be studied. DISCUSSION: This study will provide data about the use of intrapartum ST-analysis with a strict protocol for performance of FBS to limit its incidence. We aim to clarify to what extent intrapartum ST-analysis can be used without the performance of FBS and in which cases FBS is still needed. TRIAL REGISTRATION NUMBER: ISRCTN95732366
Westerweel PE, Luyten RK, Koomans HA, Derksen RH, Verhaar MC. Premature atherosclerotic cardiovascular disease in systemic lupus erythematosus. Arthritis & Rheumatism 2007; 56(5):1384-1396.
Westerweel PE, Luijten RK, Hoefer IE, Koomans HA, Derksen RH, Verhaar MC. Haematopoietic and endothelial progenitor cells are deficient in quiescent systemic lupus erythematosus. Annals of the Rheumatic Diseases 2007; 66(7):865-870.
Abstract: BACKGROUND: Systemic lupus erythematosus (SLE) is associated with a high prevalence of cardiovascular disease. Circulating endothelial progenitor cells (EPCs) contribute to vascular regeneration and repair, thereby protecting against atherosclerotic disease. EPCs are derived from CD34+ haematopoietic stem cells (HSCs), which have an increased propensity for apoptosis in the bone marrow of patients with SLE. AIM: To determine whether circulating HSCs and EPCs are reduced in SLE, contributing to an increased cardiovascular risk. METHODS: Progenitor cells were sampled from 15 female patients with SLE in prolonged clinical remission from their disease and 15 matched healthy controls. HSC and CD34+KDR+ EPCs were quantified by flow cytometry. Annexin V staining was used to identify apoptotic cells. RESULTS: Patients with SLE had reduced levels of circulating CD34+ HSCs and CD34+KDR+ EPCs, associated with increased HSC apoptosis. Compared with controls, the fraction of HSCs that could be identified as EPCs was higher in patients with SLE, consistent with a primary defect of HSCs. EPC outgrowth from mononuclear cells, which depends mainly on CD34- cells, was unaffected. CONCLUSIONS: Patients with SLE have lower levels of circulating HSCs and EPCs, even during clinical remission. The data suggest that increased HSC apoptosis is the underlying cause for this depletion. These observations indicate that progenitor cell-mediated endogenous vascular repair is impaired in SLE, which may contribute to the accelerated development of atherosclerosis.
Westerweel PE, Luyten RK, Koomans HA, Derksen RH, Verhaar MC. Reply. Arthritis & Rheumatism 2007; 56(11):3879.
Westerweel PE, Hoefer IE, Blankestijn PJ, de Bree P, Groeneveld D, van Oostrom O, Braam B, Koomans HA, Verhaar MC. End-stage renal disease causes an imbalance between endothelial and smooth muscle progenitor cells. American Journal of Physiology - Renal Physiology 2007; 292(4):F1132-F1140.
Abstract: Patients with end-stage renal disease (ESRD) on hemodialysis have an increased risk of cardiovascular disease (CVD). Circulating endothelial progenitor cells (EPC) contribute to vascular regeneration and repair, thereby protecting against CVD. However, circulating smooth muscle progenitor cells (SPC) may contribute to adverse vascular remodeling. We hypothesized that an imbalance occurs between EPC and SPC in ESRD patients and sampled progenitor cells from 45 ESRD patients receiving regular treatment. Our study is the first to show reduced numbers of CD34+KDR+ hematopoietic stem cell (HSC)-derived EPC (type I EPC). Furthermore, monocyte-derived EPC cultured from mononuclear cells (type II EPC) were reduced in number and had a reduced capacity to stimulate endothelial cell angiogenesis. In contrast, SPC outgrowth was unaffected. In vitro incubation with uremic serum impaired type II EPC outgrowth from healthy donor mononuclear cells and did not influence SPC outgrowth. The hemodialysis procedure itself induced HSC apoptosis and caused an acute depletion of circulating EPC. Taken together, the decreased number and impaired function of EPC are compatible with impaired endogenous vascular repair in hemodialysis patients, whereas the unaffected SPC numbers suggest that the potential of progenitor cells to contribute to adverse remodeling is retained. This EPC-SPC imbalance may contribute to the acceleration of CVD in ESRD patients and could offer novel therapeutic targets
Wiertsema SP, Baynam G, Khoo SK, Veenhoven RH, van Heerbeek N, Zhang G, Laing IA, Rijkers GT, Goldblatt J, Sanders EA, Le Souef PN. Impact of genetic variants in IL-4, IL-4 RA and IL-13 on the anti-pneumococcal antibody response. Vaccine 2007; 25(2):306-313.
Abstract: BACKGROUND: Significant differences in immune responses upon vaccination have been described, suggesting genetics are important in determining the magnitude of vaccine responses. The interleukin (IL)-4 pathway, including IL-4, IL-13 and the IL-4 receptor alpha chain (IL-4 Ralpha), is central to humoral responses and therefore could have an impact on vaccine responsiveness. OBJECTIVE: To investigate whether single nucleotide polymorphisms (SNPs) in the IL-4, IL-13 and IL-4 RA genes influence pneumococcal serotype-specific IgG antibody responses. METHODS: SNPs in the IL-4 gene (C -589T, G2979T), the IL-13 gene (G -1112A, Arg130Gln) and in the IL-4 RA gene (Ile50Val, Gln551Arg) were investigated in isolation and in combination, for their influence on serotype-specific IgG antibody responses upon combined pneumococcal conjugate and polysaccharide vaccinations in children with a history of recurrent otitis media. RESULTS: Lower antibody responses were observed for alleles previously associated with atopy, IL-4 -589T, IL-4 2979T and IL-4 Ralpha 551Gln. Effects were stronger in gene haplotype combinations or in multiple haplotype combination analyses. CONCLUSION: This study highlights the importance of host genetic factors in vaccine responses. Furthermore, it supports the approach of studying the effect of combinations of multiple alleles, in haplotypes or in combinations of haplotypes, on complex phenotypes within a biological pathway
Wijbenga J, Nijhuis HJ, Liem AL. First experience with ziconotide treatment in the Netherlands. Regional Anesthesia and Pain Medicine 2007; 32(5 suppl 1):52.
Wijffels MC, Timmermans CC, van Suylen RJ, Rodriguez LM. Internal atrial shock delivery by standard diagnostic electrophysiology catheters in goats: effects on atrial electrogram amplitude and tissue architecture. Europace 2007; 9(4):203-207.
Abstract: AIMS: In this study, we evaluated the effects of atrial shock delivered via diagnostic electrophysiology catheters. METHODS AND RESULTS: In 11 anaesthetized goats, decapolar catheters were positioned in the right atrial appendage (RAA) and coronary sinus (CS). Three different catheters and two cardioversion protocols were evaluated. In four goats, 50 J shocks were delivered using catheters with 1 mm electrodes (surface area 70 mm(2)). In 6 goats, catheters with 2 mm electrodes (area 140 mm(2)) were used. In three of the six goats, 50 J shocks were given while in the other 3, 10 J shocks were delivered. In 1 goat 50 J shocks were delivered via 5 mm electrode catheters (area 310 mm(2)). No persisting adverse effects occurred. However, the electrogram amplitude at the RAA and CS decreased by >50-98% (P > 0.01). The amount of amplitude decrease was most pronounced at the CS site and for 50 J shocks. Goats were sacrificed after 9 +/- 1 days. Macroscopy revealed endocardial lesions at the electrode locations. Microscopy showed endocardial thrombosis, and necrosis with formation of granulation tissue. Changes were most marked with diagnostic catheters and 50 J shocks. CONCLUSIONS: Atrial shock delivery via diagnostic catheters causes local ablation lesions. The amount of amplitude decrease, macroscopic and microscopic damages were related to the energy applied and electrode surface area
Wiltink EH. Botox en Dysport niet zomaar uitwisselbaar. Pharmaceutisch Weekblad 2007; 142(12):32-33.
Wiltink EHH, Vergeer WJ, Achterberg WP. Prevalence of renal impairment in three nursing homes in the Netherlands. Basic & Clinical Pharmacology & Toxicology 2007; 101(Suppl 1):193.
Wolzak H, Biesma DH, de Weerdt O, Meinders AJ. Spontaneous rupture of the spleen in a patient with chronic myelomonocytic leukemia. 19e Internistendagen : abstractboek :25, 26 & 27 april 2007 MECC Maastricht 2007;70-71.
Zijderveld SA, van Swieten HA, Frenken JW, Yilmaz A. Mediastinitis en cervicale fasciitis necroticans na extractie van 2 molaren. Nederlands Tijdschrift voor Tandheelkunde 2007; 114(6):267-270.
Abstract: A 38-year-old man developed dysphagia, fever and marked trismus, resulting in an abcess of the parafaryngeal region, soon after the surgical extraction of 2 mandibular molars. Despite systemic antibiotics and surgical drainage, the abcess spread to the mediastinum. Within a short space of time, cervical fasciitis necroticans and descending necrotizing mediastinitis developed. Because of the life-threatening health condition, the patient was admitted to a hospital for further treatment. He underwent surgical exploration of the cervical and sternal region, thoracotomy for mediastinal drainage, debridement, and daily mediastinal rinsing with hydrogen peroxide and betadine iodine. After 5 weeks intensive treatment, the patient could be discharged from the hospital in a fairly good condition of health
Zonneveld-Huijssoon E, Ronaghy A, van Rossum MA, Rijkers GT, van der Klis FR, Sanders EA, Vermeer-De Bondt PE, Hoes AW, van der Net JJ, Engels C, Kuis W, Prakken BJ, van Tol MJ, Wulffraat NM. Safety and efficacy of meningococcal c vaccination in juvenile idiopathic arthritis. Arthritis & Rheumatism 2007; 56(2):639-646.
Abstract: OBJECTIVE: To determine whether vaccinations aggravate the course of autoimmune diseases such as juvenile idiopathic arthritis (JIA) and whether the immune response to vaccinations may be hampered by immunosuppressive therapy for the underlying disease. METHODS: In this multicenter cohort study, 234 patients with JIA (ages 1-19 years) were vaccinated with meningococcal serogroup C (MenC) conjugate to protect against serogroup C disease (caused by Neisseria meningitidis). Patients were followed up for disease activity for 1 year, from 6 months before until 6 months after vaccination. IgG antibody titers against MenC polysaccharide and the tetanus carrier protein were determined by enzyme-linked immunosorbent assay and toxin binding inhibition assay, respectively. A serum bactericidal assay was performed to determine the function of the anti-MenC antibodies. RESULTS: No change in values for any of the 6 components of the core set criteria for juvenile arthritis disease activity was seen after MenC vaccination. Moreover, no increase in the frequency of disease relapse was detected. Mean anti-MenC IgG concentrations in JIA patients rose significantly within 6-12 weeks after vaccination. Of 157 patients tested, 153 were able to mount anti-MenC IgG serum levels >2 micro g/ml, including patients receiving highly immunosuppressive medication. The 4 patients with a lower anti-MenC antibody response displayed sufficient bactericidal activity despite receiving highly immunosuppressive medication. CONCLUSION: The MenC conjugate vaccine does not aggravate JIA disease activity or increase relapse frequency and results in adequate antibody levels, even in patients receiving highly immunosuppressive medication. Therefore, patients with JIA can be vaccinated safely and effectively with the MenC conjugate